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Denervation.

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Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.

atherosclerosis --- heart failure --- renal denervation --- renal sympathetic nerves --- kidney disease --- hypertension

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This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits.  Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.  .

Medicine & Public Health. --- Cardiology. --- Nephrology. --- Interventional Radiology. --- Medicine. --- Interventional radiology. --- Médecine --- Radiologie interventionnelle --- Cardiologie --- Néphrologie --- Hypertension, Renal -- Diagnosis. --- Renal hypertension -- Treatment. --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Hypertension --- Denervation. --- Treatment. --- Blood pressure, High --- High blood pressure --- Vascular hypertension --- Nervous system --- Blood circulation disorders --- Surgery --- Radiology, Interventional --- Medical radiology --- Therapeutics --- Internal medicine --- Kidneys --- Heart --- Diseases --- Interventional radiology .

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Despite being described for the first time more than 110 years ago, Chagas disease (caused by the parasite Trypanosoma cruzi) persists as one of the most neglected tropical diseases. This persistent neglect of those affected by this disease is evidenced by the ongoing scientific evidence gaps, the difficulty of incorporating new diagnostic and treatment technologies into the market, and public health failures to ensure timely access to diagnosis and treatment associated with the development of consistent surveillance and control actions. As a result, there is a high burden of morbidity and mortality, and poor quality of life, poverty, stigma, and a fear of death persist for affected people, both in endemic areas in Latin America, and in non-endemic areas. This book spans a variety of disciplines and contributes significantly to reducing the gap in scientific knowledge on Chagas disease, towards achieving the Sustainable Development Goals by 2030.

Medicine --- Chagas disease --- neglected tropical diseases --- migration --- healthcare rights --- mucosal leishmaniasis --- co-infection --- antimoniate therapy --- cardiomyopathy --- myocardial fibrosis --- myocardial sympathetic denervation --- inflammation --- sudden death --- cardiac magnetic resonance --- radionuclide imaging --- SPECT-CT --- PET-CT --- heart disease --- electrocardiogram --- disease progression --- stroke --- risk assessment --- Trypanosoma cruzi --- Triatoma infestans --- parasite prevalence --- coprophagy --- human illness --- neglected tropical disease --- global financing --- annual funding --- investments --- disease notification --- public policy --- neglected topical diseases --- healthcare access --- chagasic cardiomyopathy --- heart transplantation --- Chagas disease reactivation --- cardiac allograft rejection --- treatment of reactivation --- genome --- parasite --- neglected diseases --- heart transplant --- chagas disease reactivation --- Cohort studies --- Neglected diseases --- Dynamic programming --- cost of illness --- premature --- efficiency --- organizational --- life expectancy --- American trypanosomiasis --- Trypanosoma cruzi infection --- public health --- epidemiology --- prevention and control --- surveillance --- clinical research --- One Health --- Chagas disease --- neglected tropical diseases --- migration --- healthcare rights --- mucosal leishmaniasis --- co-infection --- antimoniate therapy --- cardiomyopathy --- myocardial fibrosis --- myocardial sympathetic denervation --- inflammation --- sudden death --- cardiac magnetic resonance --- radionuclide imaging --- SPECT-CT --- PET-CT --- heart disease --- electrocardiogram --- disease progression --- stroke --- risk assessment --- Trypanosoma cruzi --- Triatoma infestans --- parasite prevalence --- coprophagy --- human illness --- neglected tropical disease --- global financing --- annual funding --- investments --- disease notification --- public policy --- neglected topical diseases --- healthcare access --- chagasic cardiomyopathy --- heart transplantation --- Chagas disease reactivation --- cardiac allograft rejection --- treatment of reactivation --- genome --- parasite --- neglected diseases --- heart transplant --- chagas disease reactivation --- Cohort studies --- Neglected diseases --- Dynamic programming --- cost of illness --- premature --- efficiency --- organizational --- life expectancy --- American trypanosomiasis --- Trypanosoma cruzi infection --- public health --- epidemiology --- prevention and control --- surveillance --- clinical research --- One Health

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Recently, many kinds of foods and food-derived nutrients have been reported to show health-beneficial effects. In particular, some foods and food-derived nutrients have shown anti-aging effects on several organs and tissues, such as brain, muscle, skin, intestine, and so on. In some kinds of foods, the molecular basis of their functionalities (e.g., anti-brain aging, anti-sarcopenia, and anti-skin aging) and inter-tissue networks activated by these foods mediated by exosomes, cytokines, and immune cells have been clarified in detail.

Research & information: general --- Biology, life sciences --- Food & society --- raw-milk cheese --- Caenorhabditis elegans --- longevity --- oxidative stress --- DAF-16 --- p38 MAPK --- anthocyanins --- structure --- glucose and lipid metabolism --- human health --- meta-analysis --- telomerase reverse transcriptase --- keratinocyte–hair follicle stem cell interaction --- exosomes --- telogen–anagen transition --- hair cycle regulation --- caffeine --- intestinal aging --- anti-aging --- vitellogenesis --- mitochondrial function --- oxidative stress response --- GABA --- exosome --- gut-brain interaction --- Caco-2 --- SH-SY5Y --- argan press-cake --- MITF --- JNK --- cAMP/PKA --- Wnt/β-catenin --- microarray analysis --- maslinic acid --- muscle atrophy --- muscle strength --- denervation --- olive peel --- SGLT1 --- transporter --- tangeretin --- cardamonin --- intestinal epithelial cell --- Phgdh --- liver --- l-serine deficiency --- insulin signaling --- glucose tolerance --- inflammaging --- aging related disorders --- low grade inflammation --- nutrients --- natural herbs --- pro-inflammatory cytokines --- regulatory T cells --- retinaldehyde dehydrogenase --- IgA --- quercetin --- luteolin