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This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. .

Immunology. --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Virology. --- RNA viruses. --- Species. --- Speciation (Biology) --- Riboviruses --- Viruses, RNA --- Microbiology --- Viruses --- Genetics --- Hybridization --- Organisms --- Medical virology. --- Human genetics. --- Human Genetics. --- Heredity, Human --- Human biology --- Physical anthropology --- Immunobiology --- Life sciences --- Serology --- Medical microbiology --- Virology --- Virus diseases

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This book aims to provide mathematical analyses of nonlinear differential equations, which have proved pivotal to understanding many phenomena in physics, chemistry and biology. Topics of focus are autocatalysis and dynamics of molecular evolution, relaxation oscillations, deterministic chaos, reaction diffusion driven chemical pattern formation, solitons and neuron dynamics. Included is a discussion of processes from the viewpoints of reversibility, reflected by conservative classical mechanics, and irreversibility introduced by the dissipative role of diffusion. Each chapter presents the su

Differential equations, Nonlinear. --- Differential equations, Partial. --- Mathematical models. --- Models, Mathematical --- Simulation methods --- Partial differential equations --- Nonlinear differential equations --- Nonlinear theories --- Ordinary differential equations

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Human sciences (algemeen)