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Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.

Hypericum perforatum --- Affective disorders --- Therapeutic use. --- Treatment. --- Disorders, Affective --- Mood disorders --- Psychology, Pathological --- Common Saint Johnswort --- Klamath weed --- Perforate Saint Johnswort --- Saint Johns-wort, Common --- Saint Johnswort, Common --- St. Johnswort, Common --- Tipton's weed --- Hypericum --- Toxicology. --- Neurosciences. --- Neurology. --- Psychiatry. --- Psychotherapy. --- Biochemistry. --- Pharmacology/Toxicology. --- Plant Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Psychagogy --- Therapy (Psychotherapy) --- Mental illness --- Clinical sociology --- Mental health counseling --- Medicine and psychology --- Mental health --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Composition --- Treatment --- Diseases --- Toxicology --- Pharmacology. --- Neurology . --- Psychotherapy   . --- Plant biochemistry. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Sociology of education --- School-to-work transition --- Education --- Educational sociology --- Labor supply --- Social classes --- Pedagogiek en onderwijskunde --- Economic aspects --- Case studies. --- Effect of education on --- Social aspects --- onderwijsbeleid. --- Onderwijsbeleid.

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European unification represents major challenges to national institutional frameworks as well as significant pressures for institutional convergence. So far, labour markets have actually seen relatively little convergence, and national institutions have remained highly distinct. Against this background, the book provides an encompassing comparative analysis of school-to-work transitions in EU member states. It shows how differences in both European education and training systems, aswell as labour market institutions, generated significant variation in the experiences of young people entering E

School-to-work transition --- Youth --- Labor market --- Employment --- Young people --- Young persons --- Youngsters --- Youths --- Age groups --- Life cycle, Human --- School-to-careers programs --- School-to-work programs --- Transition, School-to-work --- Career education --- Education, Cooperative