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Protein-protein interactions.

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This dissertation by Sara Helander explores the structural biology of the c-Myc network, focusing on its regulation and interaction with other proteins. The c-Myc oncogene, often overexpressed in human cancers, is crucial for cellular growth regulation. The study delves into the disordered N-terminal domain of c-Myc, analyzing its interactions with proteins like Bin1 and Pin1 using techniques such as nuclear magnetic resonance (NMR) spectroscopy and surface plasmon resonance (SPR). These interactions are vital for the degradation of c-Myc, which, if disrupted, can lead to aggressive cell proliferation and tumorigenesis. The research provides molecular insights into the dynamics and structural properties that govern c-Myc's functionality, contributing to a broader understanding of its role in cancer. The intended audience includes researchers and professionals in molecular biology and oncology.

Oncogenes. --- Protein-protein interactions. --- Oncogenes --- Protein-protein interactions

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This dissertation by Madhanagopal focuses on the structural insights into protein-protein interactions that regulate transcription initiation and related cellular processes. The study examines the role of RNA polymerase II in eukaryotic transcription, emphasizing the formation of the Pre-Initiation Complex (PIC) and the involvement of TBP and TAF1 in this process. It also explores the ubiquitin-mediated post-translational modification of proteins, particularly through the E3 ligase TRIM21, which is significant in autoimmune pathogenesis. The work further investigates the MexR protein mutation and its implications for multidrug resistance. Using a combination of crystallography, NMR, and SAXS, this research provides a detailed molecular understanding that is crucial for structure-based drug design, targeting a scientific audience involved in molecular biology and biotechnology.

Protein-protein interactions. --- Transcription factors. --- Protein-protein interactions --- Transcription factors

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Protein-protein interactions --- Computer simulation.

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Thermodynamics. --- Protein binding. --- Protein-protein interactions.