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PETROLEUM PROSPECTING --- PETROLEUM RECOVERY --- PROCESS OPTIMIZATION --- ECONOMICS

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Der Leser wird von der Untersuchung und Darstellung empirisch vorgefundener Daten bis zu Planung und Auswertung eigener statistischer Versuchspläne durch dieses Buch begleitet. Es wird dabei ganz bewusst auf praktisch relevante und bewährte Methoden Bezug genommen und auf weiterführende wissenschaftliche Beschreibungen verzichtet. Praktisch relevante Methoden werden im Zusammenhang dargestellt. Dr. Frank Wirbeleit publiziert statistische Arbeiten seit 20 Jahren und hat langjährige Praxiserfahrung bei Unternehmen wie AMD, IBM, Intel.

Statistics --- Research --- Data processing. --- Methodology. --- Data analysis, introduction, process optimization, statistics, experimental design.

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ELECTROCHEMISTRY --- INORGANIC COMPOUNDS --- ORGANIC COMPOUNDS --- PROCESS OPTIMIZATION --- ELECTRONICS --- SEPARATION --- INTERFACE --- PREPARATION

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Founded twenty years ago, Mithra Pharmaceuticals is a Belgian biopharmaceutical company active in the women's health sector. More than ever in full growth, the company is becoming an international player in the contraceptive and menopause fields. Since 2014, Mithra has decided to focus its core activities on research and development. Its innovation activity is mainly directed towards the development of Estetrol, a natural new hormonal substance. With its innovative Estetrol-based portfolio, Mithra intends to market its first flagship product Estelle® by mid-2021. This combined oral contraceptive pill of fifth generation is expected to transform the contraceptive market, which has not seen such an innovation in over 90 years. As a potential future blockbuster with worldwide coverage, it is the subject of high expectations in terms of financial income, leaving no room for mistake. 
The pharmaceutical industry is subject to stringent regulatory constraints, high product quality requirements and shorter lead-time to market. This all puts a high financial pressure on healthcare companies and stresses their need for a reactive production strategy. The fast-paced launch of generic drugs after patent expiry also strengthen the competitiveness of the sector. 
In this context, the aim of this project thesis is to develop an appropriate production strategy for the commercial launch of this new contraceptive pill. This work aims at preparing the commercial launch in several ways: first of all, the mapping of the production process will allow Mithra to optimize and improve its efficiency by reducing its manufacturing lead time. Secondly, a strategic and tactical analysis of capacity management planning highlighted the need for alternative suppliers and the need for building safety stocks. This need is further reinforced by the unprecedented Covid-19 health crisis. Thirdly, production planning for the commercial launch emphasized the potential lack of hormone resources. With a limited amount of available hormone material, production will certainly have to be adapted and performed at tight flow, thus impacting the volume produced for the commercial launch. Finally, a comparative analysis of potential logistics providers helped the company to select the ideal partner to support its growth. This project thesis provides Mithra Pharmaceuticals with decision-support tools to best manage its first innovative contraceptive product.

Pharmaceutical industry --- fifth generation pill --- supply chain --- combined oral contraception --- blockbuster --- process optimization --- sales and operations planning --- Sciences économiques & de gestion > Production, distribution & gestion de la chaîne logistique

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Interest in Business Process Management has grown considerably in recent years. Companies are more and more concerned with improving business operations by, among other things, reducing costs or increasing customer satisfaction. In this perspective, Brunswick Marine in EMEA is seeking to optimize its parts and accessories pricing process.
This report presents the results of a 4-month project aiming to provide tools and solutions with a view to improving the pricing process of the company's parts and accessories. This optimization aspires to use Business Intelligence solutions in order to automate data processing and tracking. Indeed, the lack of integration of analytic tools into the current process prevents the company from effectively reviewing prices. Also, it is essential to redefine the pricing process before its implementation in the new ERP, which will be active in a couple of years.
The mission was carried out with a project management approach based on Lean Six Sigma's DMAIC method. The approach undertaken was, first of all, to analyze the as is pricing process and its context. Particular attention was paid to the expectations of stakeholders regarding the improvement of the system. Performance indicators have provided a measure of the current performance of the process on aspects such as price realization or time required to perform a price review. An in-depth root cause analysis of the problems was conducted using a Fishbone diagram.
Based on these investigations, the timeline related to parts and accessories price reviews has been adjusted. Analytic tools have been introduced into the process to automate data processing. These tools have been implemented on Power BI, which proves the relevance of using Business Intelligence in process optimization. Other solutions such as a harmonization of the discount system or a new product subclassification have been proposed to enhance the operational business of the department.

Business Process Management --- Pricing --- Business Process --- Process Optimization --- Business Intelligence --- Parts and Accessories Pricing --- Sciences économiques & de gestion > Gestion des systèmes d'information --- Sciences économiques & de gestion > Production, distribution & gestion de la chaîne logistique --- Sciences économiques & de gestion > Marketing