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Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread globally to pandemic proportions. Although the majority of cases have asymptomatic or mild infections, a significant proportion of cases progress to severe pneumonia and acute respiratory distress syndrome requiring critical care. Opportunistic infections following severe respiratory viral infections have been recognized since the 1918 influenza pandemic. Among critically ill patients with COVID-19, secondary fungal infections caused by Aspergillus and Candida spp. are increasingly described, affecting up to 30% of COVID-19 patients requiring intensive care treatment. This collection of manuscripts focuses on fungal infections complicating COVID-19, including immunological mechanisms and pathogenesis, diagnosis, and treatment.

Medicine --- SARS-CoV-2 --- co-infection --- pulmonary aspergillosis --- ICU --- azole-resistant Aspergillus --- Aspergillus fumigatus --- CAPA --- TR34L98H --- SARS COV-2 --- Aspergillus --- novel coronavirus --- superinfection --- risk factors --- prevalence --- challenges --- immune response --- expert statement --- European Confederation of Medical Mycology --- COVID-19 --- fungaemia --- Saccharomyces --- co-infections --- invasive aspergillosis --- putative --- probable --- Sars-CoV-2 --- PCR --- galactomannan --- classification --- COVID-19 pneumonia --- invasive pulmonary aspergillosis --- diagnosis --- multi-triazole resistance --- COVID-19 associated invasive pulmonary aspergillosis --- coinfection --- diabetes --- bloodstream infection --- Candida glabrata --- echinocandin resistance --- FKS mutation --- candidemia --- candiduria --- oral candidiasis --- mycobiome

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A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.

salivary glands --- minor salivary glands --- salivary gland carcinoma --- mucoepidermoid carcinoma --- in situ carcinoma --- intra-cystic carcinoma --- chronic kidney disease --- salivary gland dysfunction --- salivary biomarkers --- oxidative stress --- nitrosative stress --- viral infection --- Epstein-Barr virus --- HTLV-1 --- salivary gland epithelial cell --- Hashimoto’s disease --- saliva --- Sjögren’s syndrome --- autoimmune disease --- physiopathology --- treatment --- diagnosis --- review --- primary Sjögren’s syndrome --- imaging --- salivary gland --- sialography --- salivary gland ultrasonography --- magnetic resonance imaging --- sialendoscopy --- salivary gland scintigraphy --- positron emission tomography --- NF-κB --- inflammation --- autoimmunity --- innate cells --- adaptive cells --- MR sialography --- dynamic --- sublingual gland ducts --- xerostomia --- SGEC --- immortalization --- acinar --- ductal --- spheroid --- n/a --- autoimmune diseases --- Sjögren syndrome --- B-cell lymphoma --- extranodal marginal zone lymphoma --- MALT lymphoma --- primary breast lymphoma --- radiation --- hyposalivation --- purinergic signaling --- bystander effect --- P2 receptors --- radioprotection --- head and neck cancer --- oral candidiasis --- Hashimoto's disease --- Sjögren's syndrome --- primary Sjögren's syndrome --- Sjögren syndrome