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The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hypertension, and diabetes, as well as cancer. Importantly, nearly all kidney disorders have been shown to involve redox imbalance, reductive stress, oxidative stress, and mitochondrial abnormalities such as impaired mitochondrial homeostasis, including disrupted mitophagy and deranged mitochondrial unfolded protein responses. Understanding how these redox-related dysregulated pathways operate may give us new insights into how to design novel approaches to fighting kidney disease. This Special Issue of Biomolecules entitled “Redox imbalance and mitochondrial abnormalities in kidney disease” covers a variety of topics focusing on oxidative stress, mitochondrial dysfunction, and antioxidation enhancement implicated in kidney disease or kidney transplantation.

Medicine --- Pharmacology --- diabetic kidney disease --- caloric restriction --- NADH/NAD+ --- redox imbalance --- mitochondrial homeostasis --- mitophagy --- oxidative stress --- kidney allograft --- kidney rejection --- ischemia --- acute kidney injury (AKI) --- chronic kidney disease (CKD) --- tricarboxylic acid (TCA) cycle --- mitochondrial metabolism --- mitochondrial redox signaling --- mitochondrial proteins --- oxidative phosphorylation (OXPHOS) --- fatty acid (FA) β-oxidation --- mitochondrial dynamics --- biogenesis --- diabetes --- kidney --- mitochondria --- Oryza sativa --- rice husk --- TCA cycle metabolites --- kidney diseases --- renalase --- chronic kidney disease --- major adverse cardiovascular outcomes --- cadmium --- kidney injury --- renal toxicity --- oxidative damage --- proximal tubule --- controlled oxygenated rewarming --- mitochondrial uncoupling --- rewarming injury --- temperature paradox --- redox --- mitochondrial dysfunction --- SGLT2 --- mitochondrial reactive oxygen species --- Warburg effect --- podocytopathies --- mitochondrial oxidative stress --- reactive oxygen species (ROS) --- antioxidant defense --- cell death --- n/a

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The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hypertension, and diabetes, as well as cancer. Importantly, nearly all kidney disorders have been shown to involve redox imbalance, reductive stress, oxidative stress, and mitochondrial abnormalities such as impaired mitochondrial homeostasis, including disrupted mitophagy and deranged mitochondrial unfolded protein responses. Understanding how these redox-related dysregulated pathways operate may give us new insights into how to design novel approaches to fighting kidney disease. This Special Issue of Biomolecules entitled “Redox imbalance and mitochondrial abnormalities in kidney disease” covers a variety of topics focusing on oxidative stress, mitochondrial dysfunction, and antioxidation enhancement implicated in kidney disease or kidney transplantation.

Medicine --- Pharmacology --- diabetic kidney disease --- caloric restriction --- NADH/NAD+ --- redox imbalance --- mitochondrial homeostasis --- mitophagy --- oxidative stress --- kidney allograft --- kidney rejection --- ischemia --- acute kidney injury (AKI) --- chronic kidney disease (CKD) --- tricarboxylic acid (TCA) cycle --- mitochondrial metabolism --- mitochondrial redox signaling --- mitochondrial proteins --- oxidative phosphorylation (OXPHOS) --- fatty acid (FA) β-oxidation --- mitochondrial dynamics --- biogenesis --- diabetes --- kidney --- mitochondria --- Oryza sativa --- rice husk --- TCA cycle metabolites --- kidney diseases --- renalase --- chronic kidney disease --- major adverse cardiovascular outcomes --- cadmium --- kidney injury --- renal toxicity --- oxidative damage --- proximal tubule --- controlled oxygenated rewarming --- mitochondrial uncoupling --- rewarming injury --- temperature paradox --- redox --- mitochondrial dysfunction --- SGLT2 --- mitochondrial reactive oxygen species --- Warburg effect --- podocytopathies --- mitochondrial oxidative stress --- reactive oxygen species (ROS) --- antioxidant defense --- cell death

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Proteomics --- Proteins --- Biochemistry --- Proteome. --- Protéines --- Biochimie --- Biochemistry. --- Proteomics. --- Research --- genetics. --- Recherche --- Research. --- Protein research --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Proteomes --- Proteids --- Composition --- Protéines --- Molecular biology --- Biology --- Chemistry --- Medical sciences --- Biomolecules --- Polypeptides --- Health Sciences --- Physiology --- Proteome --- proteome. --- proteins. --- genetics --- Biological Sciences --- animal genetics --- cytogenetics --- gender --- genetic equilibrium --- genetic factors --- genetic relationships --- genetic selection --- genetic stability --- genetic structure --- genetic traits --- genetic vectors --- genomics --- human genetics --- immunogenetics --- inheritance (genetics) --- landscape genetics --- maternal effect --- metabolomics --- microbial genetics --- molecular genetics --- nutrigenomics --- paternal effect --- phenomics --- phenotype --- plant genetics --- population genetics --- proteomics --- quantitative genetics --- reproductive fitness --- sex determination --- transcriptomics --- biotechnology --- breeding --- genetic models --- genetic resources --- geneticists --- amino acids, peptides and proteins --- advanced glycation end products --- advanced oxidation protein products --- agglutinins --- algal proteins --- angiogenic proteins --- animal proteins --- antifreeze proteins --- antimicrobial proteins --- apoproteins --- binding proteins --- BTB-Kelch proteins --- chloroplast proteins --- conjugated proteins --- contractile proteins --- CRISPR-associated proteins --- crystal proteins --- crystallins --- cytoskeletal proteins --- gelatin --- GTPase-activating proteins --- helminth proteins --- heme proteins --- insecticidal proteins --- kinesin --- lectins --- luminescent proteins --- membrane proteins --- microbial proteins --- mitochondrial proteins --- molecular chaperones --- molecular motor proteins --- multiprotein complexes --- neoplasm proteins --- nuclear-encoded proteins --- nuclear proteins --- nucleoproteins --- peptones --- phosphoproteins --- phytohemagglutinin --- plant proteins --- polyproteins --- prions --- protein aggregates --- protein corona --- protein products --- protozoan proteins --- pulmonary surfactant associated proteins --- receptors --- recombinant proteins --- regulatory proteins --- ribonucleoproteins --- ribosomal proteins --- scaffolding proteins --- scleroproteins --- selenoproteins --- seminal plasma proteins --- silver proteins --- simple proteins --- storage proteins --- structural proteins --- sulfur proteins --- surface proteins --- thermostable proteins --- transcobalamins --- transcription factors --- tubulin --- ubiquitins --- viral proteins --- protein sweeteners --- proteinuria --- proteolytic bacteria --- proteome --- phosphoproteome --- metabolome --- proteins --- sialome --- biochemistry --- molecular biology --- proteomics --- protein science --- systems biology --- bioinformatics --- Protéomique --- Protéomes.