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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- inflammation --- innate cells --- mucosal pathology --- mediators --- homeostasis --- inflammation --- innate cells --- mucosal pathology --- mediators --- homeostasis

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A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.

Medicine --- salivary glands --- minor salivary glands --- salivary gland carcinoma --- mucoepidermoid carcinoma --- in situ carcinoma --- intra-cystic carcinoma --- chronic kidney disease --- salivary gland dysfunction --- salivary biomarkers --- oxidative stress --- nitrosative stress --- viral infection --- Epstein-Barr virus --- HTLV-1 --- salivary gland epithelial cell --- Hashimoto's disease --- saliva --- Sjögren's syndrome --- autoimmune disease --- physiopathology --- treatment --- diagnosis --- review --- primary Sjögren's syndrome --- imaging --- salivary gland --- sialography --- salivary gland ultrasonography --- magnetic resonance imaging --- sialendoscopy --- salivary gland scintigraphy --- positron emission tomography --- NF-κB --- inflammation --- autoimmunity --- innate cells --- adaptive cells --- MR sialography --- dynamic --- sublingual gland ducts --- xerostomia --- SGEC --- immortalization --- acinar --- ductal --- spheroid --- autoimmune diseases --- Sjögren syndrome --- B-cell lymphoma --- extranodal marginal zone lymphoma --- MALT lymphoma --- primary breast lymphoma --- radiation --- hyposalivation --- purinergic signaling --- bystander effect --- P2 receptors --- radioprotection --- head and neck cancer --- oral candidiasis --- salivary glands --- minor salivary glands --- salivary gland carcinoma --- mucoepidermoid carcinoma --- in situ carcinoma --- intra-cystic carcinoma --- chronic kidney disease --- salivary gland dysfunction --- salivary biomarkers --- oxidative stress --- nitrosative stress --- viral infection --- Epstein-Barr virus --- HTLV-1 --- salivary gland epithelial cell --- Hashimoto's disease --- saliva --- Sjögren's syndrome --- autoimmune disease --- physiopathology --- treatment --- diagnosis --- review --- primary Sjögren's syndrome --- imaging --- salivary gland --- sialography --- salivary gland ultrasonography --- magnetic resonance imaging --- sialendoscopy --- salivary gland scintigraphy --- positron emission tomography --- NF-κB --- inflammation --- autoimmunity --- innate cells --- adaptive cells --- MR sialography --- dynamic --- sublingual gland ducts --- xerostomia --- SGEC --- immortalization --- acinar --- ductal --- spheroid --- autoimmune diseases --- Sjögren syndrome --- B-cell lymphoma --- extranodal marginal zone lymphoma --- MALT lymphoma --- primary breast lymphoma --- radiation --- hyposalivation --- purinergic signaling --- bystander effect --- P2 receptors --- radioprotection --- head and neck cancer --- oral candidiasis