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The year 2019 has been prolific in terms of new evidence regarding the effects of coffee and caffeine consumption on diverse aspects of human functioning. This book collects 20 high-quality manuscripts published in Nutrients that include original investigation or systematic review studies of the effects of caffeine intake on human performance and health. The diversity of the articles published in this Special Issue highlights the extent of the effects of coffee and caffeine on human functioning, while underpinning the positive nature of most of these effects. This book will help with understanding why the natural sources of caffeine are so widely present in the nutrition behaviors of modern society.
NAT --- n/a --- supplementation --- EEG–EMG coherence --- muscle function --- tea --- fatigue --- ergogenic --- adrenal gland --- skeletal muscle --- xanthine oxidase --- placebo --- CMJ --- efficiency --- colorectal cancer --- rat --- pregnancy --- coffee/caffeine --- Wingate --- 1RM test --- supplement --- actigraphy --- athletic --- systematic review and meta-analysis --- women --- consumption motives --- resistance training --- cancer prevention --- sport supplement --- exercise --- DOMS --- placebo effect --- sprint performance --- power --- behavior --- belief --- health --- perceptions --- exercise performance --- ergogenic aid --- electromyography --- ergogenic effect --- corticosterone --- metabolome --- mood state --- muscle contraction --- strength --- energy drink --- repetition --- responders --- perception --- anaerobic --- CYP450 --- puberty --- energy drinks --- isokinetic testing --- individual responses --- phenotyping --- nutrition --- time under tension --- menstrual cycle --- exercise training --- RPE --- ergogenic substances --- upper limb --- elite athlete --- recovery --- speed --- epidemiology --- caffeine --- sex-difference --- bench press --- pharmacokinetics --- sport performance --- ergogenic aids --- expectancy --- consumer --- football --- newborn --- velocity --- metabolites --- performance --- coffee --- prospective studies --- resistance exercise --- sport --- EEG-EMG coherence
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Cumulative evidence demonstrates that healthy nutrient intake and regular physical exercise are both powerful lifestyle strategies that modulate lifelong health through their ability to improve body composition, musculoskeletal health, sex steroid hormones, sleep quality, and physical and cognitive performance, as well as to prevent chronic diseases across the lifespan, especially in women. While the benefits of nutrition and physical exercise are commonly studied separately, the integration of nutrition and physical exercise has the potential to produce greater benefits in women than strategies focusing only on one or the other. Studying the specificities of women in response to interventions is of the utmost importance for providing optimal healthcare and aids the design of guidelines that are better suited for women. A better knowledge regarding nutrient intake and physical exercise and their interaction in women is therefore needed. This Special Issue entitled “nutrient intake and physical exercise as modulators of healthy women” will comprise manuscripts that highlight this integrational approach as a potential modulator of lifelong outcomes in women.
Research & information: general --- Biology, life sciences --- Food & society --- soy --- ambulatory blood pressure monitoring --- aerobic exercise --- menopause --- blood pressure variability --- sedentary --- sex difference --- exercise intensity --- ventilation threshold --- fat oxidation --- octanoate --- decanoate --- women --- sex hormones --- menstrual cycle --- exercise performance --- nutritional intake --- macronutrients --- interindividual variability --- physical exercise --- aging --- oxidative stress --- antioxidant --- muscle contraction performance --- diabetes --- sarcopenia --- dietary fiber --- hypertension --- obesity --- metabolomics --- nuclear magnetic resonance --- diet --- nutrition --- dietary habits --- uterine leiomyoma --- endometriosis --- polycystic ovary syndrome --- gynecological malignancies --- normal weight obesity --- high-protein diet --- high protein snack --- body composition --- dieting --- emotional eating --- uncontrolled eating --- rumination --- weight --- restraint theory --- physical activity --- psychological aspects --- body image --- preference --- college women --- body size --- dietary restraint --- dietary behaviors --- diet quality --- online survey --- n/a
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The improvement of exercise performance in sports not only involves the enhancement of physical strength, but also includes the development of psychological and cognitive functions. There is an increasing body of evidence to show that physical exercise is a powerful way to improve a number of aspects of cognition and brain function at the systemic and behavioral levels. Yet, several questions remain: What type of exercise program is optimal for improving cognitive functions? What are the real effects of certain innovative exercise protocols on the relationship between behavior and the brain? To what extent do ergogenic aids boost cognitive function? How efficient are neuromodulation techniques in relation to behavioral performance? The answers to these questions likely require multidisciplinary insights not only from physiologists and sports scientists, but also from neuroscientists and psychologists. The manuscripts published (16 research papers and one perspective article from various academic fields) in this Special Issue Book “Exercise: A Gate That Primes the Brain to Perform” bring together current knowledge and novel directions in human exercise-cognition research dealing with performance. This book showcases the various relationships between cognitive function, brain activity, and behavioral performance with applications in sports and exercise science.
Psychology --- Muscle fatigue --- voluntary activation --- self-control --- performance --- motivation --- exercise physiology --- cognition --- high intensity interval training --- moderate intensity continuous exercise --- exercise training --- transcranial direct current stimulation (tDCS) --- whole-body movement --- motor system --- muscle strength --- high-definition transcranial direct current stimulation (HD-tDCS) --- foot muscle strength --- passive ankle kinesthesia --- static balance --- exercise --- executive functions --- core symptoms --- children --- autism spectrum disorders --- personalized training --- personalized medicine --- exercise prescription --- inhibition --- basketball --- playing positions --- Go/NoGo --- event-related potential --- volition --- brain structure --- sense of agency --- sport --- MRI --- brain regulation --- physical performance --- cognitive performance --- supplementation --- sprint start --- cerebral oxygenation --- ventral-lateral-prefrontal-cortex --- caffeine --- prolonged intermittent exercise --- exercise performance --- acute aerobic exercise --- declarative memory --- procedural memory --- coding period --- consolidation period --- resistance training --- barbell training --- strength training --- HIFT --- neurocognition --- effort --- exertion --- obesity --- inhibitory control --- aerobic exercise --- resistance exercise --- aging --- cardiovascular exercise --- fronto-parietal network --- neuroimaging --- motor performance --- priming tDCS --- cathodal --- multiple sessions --- motor learning --- neuroplasticity --- n/a
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The improvement of exercise performance in sports not only involves the enhancement of physical strength, but also includes the development of psychological and cognitive functions. There is an increasing body of evidence to show that physical exercise is a powerful way to improve a number of aspects of cognition and brain function at the systemic and behavioral levels. Yet, several questions remain: What type of exercise program is optimal for improving cognitive functions? What are the real effects of certain innovative exercise protocols on the relationship between behavior and the brain? To what extent do ergogenic aids boost cognitive function? How efficient are neuromodulation techniques in relation to behavioral performance? The answers to these questions likely require multidisciplinary insights not only from physiologists and sports scientists, but also from neuroscientists and psychologists. The manuscripts published (16 research papers and one perspective article from various academic fields) in this Special Issue Book “Exercise: A Gate That Primes the Brain to Perform” bring together current knowledge and novel directions in human exercise-cognition research dealing with performance. This book showcases the various relationships between cognitive function, brain activity, and behavioral performance with applications in sports and exercise science.
Muscle fatigue --- voluntary activation --- self-control --- performance --- motivation --- exercise physiology --- cognition --- high intensity interval training --- moderate intensity continuous exercise --- exercise training --- transcranial direct current stimulation (tDCS) --- whole-body movement --- motor system --- muscle strength --- high-definition transcranial direct current stimulation (HD-tDCS) --- foot muscle strength --- passive ankle kinesthesia --- static balance --- exercise --- executive functions --- core symptoms --- children --- autism spectrum disorders --- personalized training --- personalized medicine --- exercise prescription --- inhibition --- basketball --- playing positions --- Go/NoGo --- event-related potential --- volition --- brain structure --- sense of agency --- sport --- MRI --- brain regulation --- physical performance --- cognitive performance --- supplementation --- sprint start --- cerebral oxygenation --- ventral-lateral-prefrontal-cortex --- caffeine --- prolonged intermittent exercise --- exercise performance --- acute aerobic exercise --- declarative memory --- procedural memory --- coding period --- consolidation period --- resistance training --- barbell training --- strength training --- HIFT --- neurocognition --- effort --- exertion --- obesity --- inhibitory control --- aerobic exercise --- resistance exercise --- aging --- cardiovascular exercise --- fronto-parietal network --- neuroimaging --- motor performance --- priming tDCS --- cathodal --- multiple sessions --- motor learning --- neuroplasticity --- n/a
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The improvement of exercise performance in sports not only involves the enhancement of physical strength, but also includes the development of psychological and cognitive functions. There is an increasing body of evidence to show that physical exercise is a powerful way to improve a number of aspects of cognition and brain function at the systemic and behavioral levels. Yet, several questions remain: What type of exercise program is optimal for improving cognitive functions? What are the real effects of certain innovative exercise protocols on the relationship between behavior and the brain? To what extent do ergogenic aids boost cognitive function? How efficient are neuromodulation techniques in relation to behavioral performance? The answers to these questions likely require multidisciplinary insights not only from physiologists and sports scientists, but also from neuroscientists and psychologists. The manuscripts published (16 research papers and one perspective article from various academic fields) in this Special Issue Book “Exercise: A Gate That Primes the Brain to Perform” bring together current knowledge and novel directions in human exercise-cognition research dealing with performance. This book showcases the various relationships between cognitive function, brain activity, and behavioral performance with applications in sports and exercise science.
Psychology --- Muscle fatigue --- voluntary activation --- self-control --- performance --- motivation --- exercise physiology --- cognition --- high intensity interval training --- moderate intensity continuous exercise --- exercise training --- transcranial direct current stimulation (tDCS) --- whole-body movement --- motor system --- muscle strength --- high-definition transcranial direct current stimulation (HD-tDCS) --- foot muscle strength --- passive ankle kinesthesia --- static balance --- exercise --- executive functions --- core symptoms --- children --- autism spectrum disorders --- personalized training --- personalized medicine --- exercise prescription --- inhibition --- basketball --- playing positions --- Go/NoGo --- event-related potential --- volition --- brain structure --- sense of agency --- sport --- MRI --- brain regulation --- physical performance --- cognitive performance --- supplementation --- sprint start --- cerebral oxygenation --- ventral-lateral-prefrontal-cortex --- caffeine --- prolonged intermittent exercise --- exercise performance --- acute aerobic exercise --- declarative memory --- procedural memory --- coding period --- consolidation period --- resistance training --- barbell training --- strength training --- HIFT --- neurocognition --- effort --- exertion --- obesity --- inhibitory control --- aerobic exercise --- resistance exercise --- aging --- cardiovascular exercise --- fronto-parietal network --- neuroimaging --- motor performance --- priming tDCS --- cathodal --- multiple sessions --- motor learning --- neuroplasticity --- Muscle fatigue --- voluntary activation --- self-control --- performance --- motivation --- exercise physiology --- cognition --- high intensity interval training --- moderate intensity continuous exercise --- exercise training --- transcranial direct current stimulation (tDCS) --- whole-body movement --- motor system --- muscle strength --- high-definition transcranial direct current stimulation (HD-tDCS) --- foot muscle strength --- passive ankle kinesthesia --- static balance --- exercise --- executive functions --- core symptoms --- children --- autism spectrum disorders --- personalized training --- personalized medicine --- exercise prescription --- inhibition --- basketball --- playing positions --- Go/NoGo --- event-related potential --- volition --- brain structure --- sense of agency --- sport --- MRI --- brain regulation --- physical performance --- cognitive performance --- supplementation --- sprint start --- cerebral oxygenation --- ventral-lateral-prefrontal-cortex --- caffeine --- prolonged intermittent exercise --- exercise performance --- acute aerobic exercise --- declarative memory --- procedural memory --- coding period --- consolidation period --- resistance training --- barbell training --- strength training --- HIFT --- neurocognition --- effort --- exertion --- obesity --- inhibitory control --- aerobic exercise --- resistance exercise --- aging --- cardiovascular exercise --- fronto-parietal network --- neuroimaging --- motor performance --- priming tDCS --- cathodal --- multiple sessions --- motor learning --- neuroplasticity
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This book entitled “Cocoa, Chocolate, and Human Health” presents the most recent findings about cocoa and health in 14 peer-reviewed chapters including nine original contributions and five reviews from cocoa experts around the world. Bioavailability and metabolism of the main cocoa polyphenols, i.e., the flavanols like epicatechin, are presented including metabolites like valerolactones that are formed by the gut microbiome. Many studies, including intervention studies or epidemiological observations, do not focus on single compounds, but on cocoa as a whole. This proves the effectiveness of cocoa as a functional food. A positive influence of cocoa on hearing problems, exercise performance, and metabolic syndrome is discussed with mixed results; the results about exercise performance are contradictive. Evidence shows that cocoa flavanols may modulate some risk factors related to metabolic syndrome such as hypertension and disorders in glucose and lipid metabolism. However, several cardiometabolic parameters in type 2 diabetics were not affected by a flavanol-rich cocoa powder as simultaneous treatment with pharmaceuticals might have negated the effect of cocoa. The putative health-promoting components of cocoa are altered during processing like fermentation, drying, and roasting of cocoa beans. Chocolate, the most popular cocoa product, shows remarkable losses in polyphenols and vitamin E during 18 months of storage.
n/a --- lipids --- theobromine --- colonic bacteria --- ?-glucosidase inhibition --- cacao --- tinnitus --- antioxidant capacity --- metabolomics --- methylxanthines --- lipid status --- physical exercise --- skeletal muscle --- functional volatile compounds --- soluble cocoa products --- blood pressure --- flavanols --- functional food --- classification --- monitoring --- cocoa --- yeast --- quality --- flavanols bioavailability --- fermentation --- cocoa processing --- hearing loss --- Italian chocolate --- chocolate --- (?)-catechin --- extraction and characterization methods --- heath potentials --- CREB --- inflammation --- flavanol-rich cocoa --- behavior --- (?)-epicatechin --- BDNF --- plasma appearance --- flavan-3-ol stereoisomers --- fermentation-related enzymes --- angiotensin-converting enzyme (ACE) inhibitory activity --- type 2 diabetes --- CaMKII --- exercise performance --- anti-inflammatory properties --- (+)-catechin --- bioactive compounds --- chiral separation --- plasma --- oxidative stress --- antidiabetic capacity --- polyphenols --- oligopeptides --- urine --- protein–phenol interactions --- postprandial --- working memory --- procyanidins --- simulated gastrointestinal digestion --- cocoa-based ingredients --- one-compartment model --- cocoa beans --- athlete --- biomarkers --- polyphenol --- metabolic syndrome --- nutrition --- bioavailability --- roasting --- glucose metabolism --- cohort study --- plasma nutrikinetics --- pharmacokinetics --- human --- cocoa proteins --- metabolites --- cocoa by-product --- meal --- bioactive peptides --- performance --- liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (LC-ESI-QToF-MS) --- starter culture --- protein-phenol interactions --- health potentials
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Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue.
Research & information: general --- Biology, life sciences --- Food & society --- ergogenic aids --- cellular metabolism --- phosphagens --- sarcopenia --- cognition --- diabetes --- creatine synthesis deficiencies --- concussion --- traumatic brain injury --- spinal cord injury --- muscle atrophy --- rehabilitation --- pregnancy --- immunity --- anti-inflammatory --- antioxidant --- anticancer --- creatine --- nutritional supplements --- fertility --- newborn --- development --- brain injury --- post-viral fatigue syndrome --- chronic fatigue syndrome --- GAA --- creatine kinase --- dietary supplements --- exercise --- skeletal muscle --- glycemic control --- type 2 diabetes mellitus --- phosphorylcreatine --- dietary supplement --- ergogenic aid --- youth --- athletes --- osteoporosis --- osteosarcopenia --- frailty --- cachexia --- innate immunity --- adaptive immunity --- inflammation --- macrophage polarization --- cytotoxic T cells --- toll-like receptors --- vascular pathology --- cardiovascular disease --- oxidative stress --- vascular health --- female --- menstrual cycle --- hormones --- exercise performance --- menopause --- mood --- children --- height --- BMI-for-age --- stature-for-age --- growth --- phosphocreatine --- creatine transporter --- supplementation --- treatment --- heart --- heart failure --- ischemia --- myocardial infarction --- anthracycline --- cardiac toxicity --- energy metabolism --- cell survival --- bioinformatics --- systems biology --- cellular allostasis --- dynamic biosensor --- pleiotropic effects of creatine (Cr) supplementation --- inflammatory bowel diseases (IBD) --- ulcerative colitis --- Crohn’s disease --- creatine kinase (CK) --- phosphocreatine (PCr) --- creatine transporter (CrT) --- intestinal epithelial cell protection --- intestinal tissue protection --- creatine perfusion --- organ transplantation --- Adenosine mono-phosphate (AMP) --- activated protein kinase (AMPK) --- liver kinase B1 (LKB1) --- mitochondrial permeability transition pore (mPTP) --- reactive oxygen species (ROS) --- glucose transporter (GLUT) --- T cell antitumor immunity --- metabolic regulator --- cancer immunotherapy --- supplements --- muscle damage --- recovery --- immobilization --- atrophy --- muscular dystrophy --- amyotrophic lateral sclerosis --- Parkinson’s Disease --- cardiopulmonary disease --- mitochondrial cytopathy --- hypertrophy --- athletic performance --- weightlifting --- resistance exercise --- training --- muscular power --- muscular adaptation --- muscle fatigue --- adipose tissue --- muscle strength --- physiological adaptation --- mitochondria --- thermogenesis --- MAP kinase signaling system --- sodium-chloride-dependent neurotransmitter symporters --- signal transduction --- intradialytic creatine supplementation --- hemodialysis --- muscle --- protein energy wasting --- clinical trial --- muscle weakness --- chronic fatigue --- cognitive impairment --- depression --- anemia --- resistance training --- sports nutrition --- strength --- toxicity --- methylation --- hyperhomocysteinemia --- neuromodulation --- MCDA --- mitochondriopathia --- cardiac infarction --- long COVID --- hypoxia --- stroke --- neurodegenerative diseases --- noncommunicable disease --- adenosine 5′-monopnophosphate-activated protein kinase --- anthracyclines --- creatine supplementation --- cardiac signaling --- cardiotoxicity --- doxorubicin --- soy --- vegetarian/vegan diet --- amino acids --- dietary ingredients --- performance --- ergogenic aids --- cellular metabolism --- phosphagens --- sarcopenia --- cognition --- diabetes --- creatine synthesis deficiencies --- concussion --- traumatic brain injury --- spinal cord injury --- muscle atrophy --- rehabilitation --- pregnancy --- immunity --- anti-inflammatory --- antioxidant --- anticancer --- creatine --- nutritional supplements --- fertility --- newborn --- development --- brain injury --- post-viral fatigue syndrome --- chronic fatigue syndrome --- GAA --- creatine kinase --- dietary supplements --- exercise --- skeletal muscle --- glycemic control --- type 2 diabetes mellitus --- phosphorylcreatine --- dietary supplement --- ergogenic aid --- youth --- athletes --- osteoporosis --- osteosarcopenia --- frailty --- cachexia --- innate immunity --- adaptive immunity --- inflammation --- macrophage polarization --- cytotoxic T cells --- toll-like receptors --- vascular pathology --- cardiovascular disease --- oxidative stress --- vascular health --- female --- menstrual cycle --- hormones --- exercise performance --- menopause --- mood --- children --- height --- BMI-for-age --- stature-for-age --- growth --- phosphocreatine --- creatine transporter --- supplementation --- treatment --- heart --- heart failure --- ischemia --- myocardial infarction --- anthracycline --- cardiac toxicity --- energy metabolism --- cell survival --- bioinformatics --- systems biology --- cellular allostasis --- dynamic biosensor --- pleiotropic effects of creatine (Cr) supplementation --- inflammatory bowel diseases (IBD) --- ulcerative colitis --- Crohn’s disease --- creatine kinase (CK) --- phosphocreatine (PCr) --- creatine transporter (CrT) --- intestinal epithelial cell protection --- intestinal tissue protection --- creatine perfusion --- organ transplantation --- Adenosine mono-phosphate (AMP) --- activated protein kinase (AMPK) --- liver kinase B1 (LKB1) --- mitochondrial permeability transition pore (mPTP) --- reactive oxygen species (ROS) --- glucose transporter (GLUT) --- T cell antitumor immunity --- metabolic regulator --- cancer immunotherapy --- supplements --- muscle damage --- recovery --- immobilization --- atrophy --- muscular dystrophy --- amyotrophic lateral sclerosis --- Parkinson’s Disease --- cardiopulmonary disease --- mitochondrial cytopathy --- hypertrophy --- athletic performance --- weightlifting --- resistance exercise --- training --- muscular power --- muscular adaptation --- muscle fatigue --- adipose tissue --- muscle strength --- physiological adaptation --- mitochondria --- thermogenesis --- MAP kinase signaling system --- sodium-chloride-dependent neurotransmitter symporters --- signal transduction --- intradialytic creatine supplementation --- hemodialysis --- muscle --- protein energy wasting --- clinical trial --- muscle weakness --- chronic fatigue --- cognitive impairment --- depression --- anemia --- resistance training --- sports nutrition --- strength --- toxicity --- methylation --- hyperhomocysteinemia --- neuromodulation --- MCDA --- mitochondriopathia --- cardiac infarction --- long COVID --- hypoxia --- stroke --- neurodegenerative diseases --- noncommunicable disease --- adenosine 5′-monopnophosphate-activated protein kinase --- anthracyclines --- creatine supplementation --- cardiac signaling --- cardiotoxicity --- doxorubicin --- soy --- vegetarian/vegan diet --- amino acids --- dietary ingredients --- performance
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Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue.
ergogenic aids --- cellular metabolism --- phosphagens --- sarcopenia --- cognition --- diabetes --- creatine synthesis deficiencies --- concussion --- traumatic brain injury --- spinal cord injury --- muscle atrophy --- rehabilitation --- pregnancy --- immunity --- anti-inflammatory --- antioxidant --- anticancer --- creatine --- nutritional supplements --- fertility --- newborn --- development --- brain injury --- post-viral fatigue syndrome --- chronic fatigue syndrome --- GAA --- creatine kinase --- dietary supplements --- exercise --- skeletal muscle --- glycemic control --- type 2 diabetes mellitus --- phosphorylcreatine --- dietary supplement --- ergogenic aid --- youth --- athletes --- osteoporosis --- osteosarcopenia --- frailty --- cachexia --- innate immunity --- adaptive immunity --- inflammation --- macrophage polarization --- cytotoxic T cells --- toll-like receptors --- vascular pathology --- cardiovascular disease --- oxidative stress --- vascular health --- female --- menstrual cycle --- hormones --- exercise performance --- menopause --- mood --- children --- height --- BMI-for-age --- stature-for-age --- growth --- phosphocreatine --- creatine transporter --- supplementation --- treatment --- heart --- heart failure --- ischemia --- myocardial infarction --- anthracycline --- cardiac toxicity --- energy metabolism --- cell survival --- bioinformatics --- systems biology --- cellular allostasis --- dynamic biosensor --- pleiotropic effects of creatine (Cr) supplementation --- inflammatory bowel diseases (IBD) --- ulcerative colitis --- Crohn’s disease --- creatine kinase (CK) --- phosphocreatine (PCr) --- creatine transporter (CrT) --- intestinal epithelial cell protection --- intestinal tissue protection --- creatine perfusion --- organ transplantation --- Adenosine mono-phosphate (AMP) --- activated protein kinase (AMPK) --- liver kinase B1 (LKB1) --- mitochondrial permeability transition pore (mPTP) --- reactive oxygen species (ROS) --- glucose transporter (GLUT) --- T cell antitumor immunity --- metabolic regulator --- cancer immunotherapy --- supplements --- muscle damage --- recovery --- immobilization --- atrophy --- muscular dystrophy --- amyotrophic lateral sclerosis --- Parkinson’s Disease --- cardiopulmonary disease --- mitochondrial cytopathy --- hypertrophy --- athletic performance --- weightlifting --- resistance exercise --- training --- muscular power --- muscular adaptation --- muscle fatigue --- adipose tissue --- muscle strength --- physiological adaptation --- mitochondria --- thermogenesis --- MAP kinase signaling system --- sodium-chloride-dependent neurotransmitter symporters --- signal transduction --- intradialytic creatine supplementation --- hemodialysis --- muscle --- protein energy wasting --- clinical trial --- muscle weakness --- chronic fatigue --- cognitive impairment --- depression --- anemia --- resistance training --- sports nutrition --- strength --- toxicity --- methylation --- hyperhomocysteinemia --- neuromodulation --- MCDA --- mitochondriopathia --- cardiac infarction --- long COVID --- hypoxia --- stroke --- neurodegenerative diseases --- noncommunicable disease --- adenosine 5′-monopnophosphate-activated protein kinase --- anthracyclines --- creatine supplementation --- cardiac signaling --- cardiotoxicity --- doxorubicin --- soy --- vegetarian/vegan diet --- amino acids --- dietary ingredients --- performance
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