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Lung neutrophilic inflammation has emerged as a potential target in a preventive or therapeutic approach of lung cancer. Unfortunately, available anti-inflammatory drugs such as budesonide do not allow a good control of this disease, justifying the interest of the industry for therapeutic alternatives. Thehydroxypropyl-cyclodextrin­ budesonide complex has shown a promising potential in the treatment of lung neutrophilic inflammation and is currently undergoing preclinical and clinical studies, but no investigation of its mechanism of action has yet been undertaken. The purpose of this study was therefore to initiate the study of the issue by the experimental approach.Our research hypothesis states that the hydroxypropyl- -cyclodextrin-budesonide complex could change the cholesterol-dependent biophysical properties of cell membranes, particularly the cholesterol-enriched membrane domains called rafts, by complexing the membrane cholesterol. This modification would then result among other effects in disruption of raft-dependent inflammatory cell signaling. This hypothesis was tested by evaluating: (1) the effect of hydroxypropyl--cyclodextrin-budesonide complex on the physical properties of liposomes, which mimic the lipid bilayer of plasma membranes;(2) the cytotoxicity of hydroxypropyl--cyclodextrin- budesonide complex;(3) the effect of hydroxypropyl- -cyclodextrin-budesonide complex compared with budesonide alone on the production of LPS-induced IL-8 production in A549 cells that mimic the human alveolar epithelial cells type 2 and whose rafts were previously destabilized by a pretreatment with methyl--cyclodextrin.The results obtained show that the hydroxypropyl--cyclodextrin-budesonide complex modifies the physical properties of liposomes by a cholesterol-dependent mechanism. The results also suggest that the hydroxypropyl- cyclodextrin-budesonide complex has a low cytotoxicity and causes a slight decrease compared with budesonide alone of the LPS-induced IL-8 production induced by A549 cells pretreated with methyl -cyclodextrin.To conclude, we can propose that the hydroxypropyl--cyclodextrin-budesonide complex has the ability to modify the stability of rafts which would inhibit the raft-dependent inflammatory cell response. Le cancer pulmonaire est la première cause européenne de mortalité par cancer chez l'homme, et la deuxième chez la femme après le cancer du sein. Des estimations effectuées pour l'année 2014 dans l'union européenne indiquent quele cancer pulmonaire représenterait 25% des morts par cancer chez les hommes et 14,5% chez les femmes. La mortalité par cancer pulmonaire en Europe continue de croitre chez les femmes alors que la tendance est à la baisse pour le cancer du sein. Le cancer pulmonaire se place ainsi en" favori " pour devenir aussi le premier tueur par cancer chezla femme dansles années à venir (Malvezzi et al., 2014).L'exposition à la fumée de tabac est le facteur causal le mieux caractérisé du cancer pulmonaire, mais d'autres polluants atmosphériques comme la fumée de diesel ou l'ozone participent aussi à sa pathogénèse (Witschi, 1988 ; Jerett et al., 2009). Parmi les mécanismes qui relient l'exposition aux polluants atmosphériques et le cancer pulmonaire, l'inflammation pulmonaire à neutrophiles, caractéristique physiopathologique majeure de la bronchopneumopathie chronique obstructive (COPD), occupe une place particulière. En effet, elle est une conséquence spécifique de l'exposition chronique à ces polluants et des études épidémiologiques et expérimentales l'ont directement associée au cancer pulmonaire (Fridlender ZG et al., 2009 ; Young RP et al., 2009 ;de Torres JP et al., 2011). De ce fait, l'inflammation pulmonaire à neutrophiles/COPD apparait comme une cible potentielle dans une approche préventive ou thérapeutique du cancer pulmonaire.Les anti-inflammatoires disponibles semblent malheureusement assez peu efficaces dans le contrôle de l'inflammation pulmonaire à neutrophiles/COPD, justifiant l'intérêt de l'industrie pour la conception de nouveaux moyens thérapeutiques (Hoenderdos & Condliffe, 2013). Parmi les alternatives pharmacologiques potentielles, le complexe hydroxypropyl-B-cyclodextrine-budesonide est apparu très prometteur et fait actuellement l'objet d'études précliniques et cliniques approfondies. Cependant, le mécanisme d'action cellulaire et moléculaire du complexe hydroxypropyl-B-cyclodextri ne-budesonide est un point sur lequel aucune investigation n'a encore été entreprise. Ce travail de mémoire a ainsi été mis sur pied afin de pallier à ce manquement en initiant l'étude de la question par l'approche expérimentale. Avant d'entrer dans le vif du sujet, il semble important d'effectuer une analyse de l'état des connaissances actuelles disponibles afin d'appréhender le cheminement qui a conduit à l'élaboration de l'hypothèse de recherche qui a orienté ce travail,et de justifier la méthodologie adoptée.

Budesonide, Formoterol Fumarate Drug Combination --- Lung Neoplasms --- 2-hydroxypropyl-beta-cyclodextrin --- Anti-Inflammatory Agents, Non-Steroidal

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This is a reprint of the Special Issue "Cyclodextrin Chemistry and Toxicology”. This is a collection of eleven articles and three reviews that was published in Molecules that provides an overview of the applications of cyclodextrins, implements the information regarding the use of cyclodextrins and their inclusion complexes, considering both experimental and theorists approaches and using various scientific and technological tools.

Research & information: general --- Biology, life sciences --- cyclodextrin --- sulfamethazine --- zwitterion --- host-guest complex --- thermodynamics --- nanosponges --- β-cyclodextrin --- glutathione --- cancer --- multicellular spheroids --- inclusion complexes --- solubilization --- nanosponge --- nanocarriers --- pharmaceutical applications --- molecular recognition phenomena --- molecular dynamics simulations --- drug delivery --- drug concentration --- dyeing --- textile finishing --- textile wastewater --- cyclodextrins --- HPβCD --- budesonide --- inflammation --- ROS --- Akt --- HDAC --- cholesterol --- medical imaging --- contrast agents --- α-cyclodextrin --- γ-cyclodextrin --- MRI --- PET --- CT --- SPECT --- PAI --- Cinnamomum osmophloeum --- linalool --- microencapsulation --- cyclodextrin inclusion --- solution-phase --- solid state --- antiretroviral --- 3-hydroxyflavone (3HF) --- γ-cyclodextrin (γ-CD) --- excited-state proton transfer (ESPT) --- molecular dynamics (MD) --- density functional theory (DFT) --- cyclodextrin polymers --- synthesis --- separation science --- materials science --- biomedicine --- retinal explant --- cytotoxicity --- uptake --- risperidone --- inclusion complex --- randomly methylated β-cyclodextrin --- compatibility studies --- excipients --- solubility --- stability --- aggregation --- doxorubicin --- nanoparticles --- alveograph --- wheat dough --- bread staling

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Phytochemicals from natural products are now widely used as food additives (antioxidants, pigments), food supplements, cosmetic ingredients, etc. Currently, the majority of the extraction processes implemented on an industrial scale for the production of bioactive-enriched extracts are based on solvents of petroleum origin. However, contemporary trends in green extraction techniques dictate a minimization of solvent use, low-energy processes and novel eco-friendly materials that are environmentally benign. The search for liquids and/or extraction technologies that could meet such requirements is, therefore, an intriguing concept. This book addresses the concept of recovering natural bioactive substances from plant resources, using state-of-the-art extraction technologies, with prospects in the food, cosmetic and pharmaceutical industries.

cosmeceutical product --- long-lived trees --- simplex-centroid mixture design --- deep eutectic solvents --- bioactivity --- flavonoids --- extraction --- deep eutectic solvents (DES) --- natural deep eutectic solvents (NaDES) --- Moringa oleifera --- polyphenols --- ultrasonication pretreatment --- antioxidants --- hydroxypropyl β-cyclodextrin --- potato peels --- grape seed --- grape skin --- green extraction --- antioxidant activity --- chlorogenic acid --- caffeine --- β-cyclodextrin --- coffee pulp --- sensory analysis --- cold brew --- n/a

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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

tissue engineering --- cyclodextrin --- permeability --- poly (vinylpyrrolidone-co-vinyl acetate) --- crystalline --- antibacterial --- drug delivery --- homogenization --- capsaicin --- combination therapy --- high-shear mixing --- cyclodextrin-inclusion complexes --- amorphous --- high-speed electrospinning --- PMVE/MA --- aqueous solubility enhancement --- sieve analysis --- Raman mapping --- Eudragit --- nanofibers --- psoriasis --- PCL --- essential oils --- parameters --- antibiotics --- xanthan gum --- carvedilol --- amorphous composite --- coaxial electrospinning --- insoluble drug --- NIR-triggered drug release --- fast dissolution --- electrospinning --- oral drug delivery --- electrospun nanofibers --- poly-cyclodextrin --- TRPV1 --- gallic acid --- solid dispersion --- photothermal therapy --- drug release --- applications --- Drug delivery systems. --- Electrospinning. --- Nanoparticles. --- Nano-particles --- NPs (Nanoparticles) --- Nanoscale particles --- Nanostructured materials --- Particles --- Spinning --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Delivery systems

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The Special Issue "Extractable and Non-Extractable Antioxidants" gives an updated view on antioxidants-both in their extractable and non-extractable form-in the different food groups, their products thereof, and food preparations as well as byproducts and biomass waste. The potential beneficial properties of these compounds and nutraceutical formulations are described in the various studies covered in this Special Issue.

biorefinery --- polyphenols --- polymerization --- n/a --- black teas --- nutrient --- ultrasound assisted extraction --- cyclodextrin --- HPLC-ESI/MS --- legumes --- degradation --- LC-ESI-Q-TOF-MS --- antioxidant activity --- forest residues --- multivariate analysis --- bio-based --- chemometrics --- extractable polyphenols --- extractable compounds --- pre-column HPLC method --- Cagnulari marc --- antioxidant capacity --- flour --- total polyphenol content (TPC) --- digestibility --- ferric reducing antioxidant power (FRAP) --- natural antioxidants --- dietary assessment. --- eggplant --- antioxidant --- botanicals --- anthocyanins --- trans-cinnamaldehyde --- anti-inflammation --- cereals --- functional ingredient --- food composition database --- agglomerative hierarchical clustering --- circular economy --- fermentation --- Aloysia triphylla --- Naviglio Extractor® --- flavonols glycosides --- self-inclusion --- phenolic contents --- grape seed --- integrated food research --- antioxidants --- dedicated databases --- phenolic compounds --- non-extractable compounds --- value-added by-products --- phenolic acids --- dietary supplements --- berries jam --- phenolics --- inclusion complex --- sour cherry --- Pleurotus ostreatus --- catechins --- proanthocyanidins --- Chinese mistletoes --- nuclear magnetic spectroscopy --- nitric oxide scavengers --- quercitrin --- endothelial cell --- polyphenolic compounds --- Italian popular recipes --- green extraction --- non-extractable polyphenols --- classic extraction --- study approach --- daidzein --- ?-cyclodextrin --- Camellia sinensis --- antioxidant properties --- digestive enzyme --- extractable --- bioactive compounds --- principal component analysis --- non-extractable --- oxidative stress