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The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody-drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.

graphene oxide --- indole --- androgens --- cyclooxygenase-2 --- cyclooxygenase-1 --- heteropolysaccharide --- drug conjugation --- drug delivery --- ellipticine --- chemical linker --- oesophageal cancer --- antiproliferative activity --- topoisomerase II --- ?-lactam --- DSD --- antibody --- topoisomerase inhibitors --- magnetic targeting --- cisplatin resistance --- steroidogenesis --- [18F]FDG PET/CT --- heterocyclic chemistry --- dehydroepiandrosterone --- antimitotic --- 3-vinylazetidin-2-ones --- glioblastoma --- and cancer therapy --- intestinal mucositis --- Combretastatin A-4 --- metabolism --- anti-cancer drugs --- maghemite --- COX-1 inhibitor --- anticancer --- CYP17A1 --- conjugate and hybrid drugs --- inflammation --- snticancer drugs --- P450c17 --- tumorigenesis --- cisplatin --- biomarker profiling --- cancer drug design --- tubulin --- cytochrome P450 --- 5-fluorouracil --- prostate cancer --- abiraterone --- NCI screen --- radiation --- cancer immunotherapy --- microtubule targeted drugs --- cancer --- treatment resistance

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Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and phenolic acids, and so on, with a wide range of biological activities. In order to explore our knowledge of phytochemicals with the assistance of modern molecular tools and high-throughput technologies, this book collects recent innovative original research and review articles on subtopics of mechanistic insights into bioactivities, treatment of diseases, profiling, extraction and identification, and biotechnology.

Medicine --- network pharmacology --- traditional herbal medicine --- methodological trend --- polysaccharide fraction --- Trichoderma atroviride --- Salvia miltiorrhiza --- proteomics --- tanshinones --- Flos Chrysanthemi indici --- essential oil --- extraction method --- chemical composition --- biological activity --- Garcinia linii --- hypoglycemia --- benzopyran --- triterpene --- bioflavonoid --- phenolic --- in silico --- neurodegenerative diseases --- naringenin --- pharmacological targets --- signaling pathways --- molecular mechanisms --- drug delivery systems --- luteolin --- hyphenated techniques --- chromatography --- colorectal cancer --- diterpenes --- inflammatory bowel diseases --- Polyalthia longifolia --- herbal medicine --- DESs --- preparative-scale purification --- flavonoids --- 20-hydroxyecdysone --- Chenopodium quinoa --- Zinc oxide nanoparticles --- anticancer --- antileishmanial --- antimicrobial --- biocompatibility --- cancer --- apoptosis --- herbs --- cell lines --- in vivo --- quercetin --- polyphenols --- Alzheimer's disease --- mechanistic insights --- clinical directions --- isodon genus --- ent-kaurane diterpenoids --- natural compounds --- pathways --- medicinal plants --- bioactive compounds --- 4-hydroxynonenal --- deleterious effects --- Asiatic acid --- nasopharyngeal cancer --- cisplatin resistance --- MAPK pathway --- Anthocyanin --- Solanum nigrum L. --- flavonoid biosynthesis --- AtPAP1 --- licochalcone D --- non-small cell lung cancer --- reactive oxygen species --- Acorus gramineusand --- Euodia ruticarpa --- pro-/anti-inflammatory cytokines --- steam distillation essential oil --- Th1/Th2 cytokines --- lignans --- Trachelospermum asiaticum --- GNPS --- targeted isolation --- Rheum undulatum --- Glycyrriza uralensis --- hepatic encephalopathy --- MMP-9 --- neuroinflammation --- luteolin-7-O-glucoside --- oral cancer --- migration --- invasion --- MMP-2 --- Astragalus mongholicus --- ultraviolet-B radiation --- phenolics --- untargeted gas chromatography-mass spectrometry --- targeted liquid chromatography-mass spectrometry --- Bacopa monnieri --- cheminformatics --- neurological diseases --- spinocerebellar ataxia --- system pharmacology --- (-)-epigallocatechin-3-gallate (EGCG) --- bone morphogenetic protein-2 (BMP-2) --- catethin --- fracture healing --- local use --- cardiovascular diseases --- inflammation --- lipid metabolism --- non-coding RNA --- oxidative stress --- phenolic compounds --- Peucedanum ostruthium --- Apiaceae --- ELINA --- HetCA, STOCSY --- coumarines --- NF-ĸB --- VCAM-1 --- E-selectin --- Withaferin A --- matrix metalloproteinases --- antioxidant signaling --- Curcuma aromatica --- sesquiterpene --- anti-inflammatory --- luciferase assay --- cytotoxicity

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and phenolic acids, and so on, with a wide range of biological activities. In order to explore our knowledge of phytochemicals with the assistance of modern molecular tools and high-throughput technologies, this book collects recent innovative original research and review articles on subtopics of mechanistic insights into bioactivities, treatment of diseases, profiling, extraction and identification, and biotechnology.

network pharmacology --- traditional herbal medicine --- methodological trend --- polysaccharide fraction --- Trichoderma atroviride --- Salvia miltiorrhiza --- proteomics --- tanshinones --- Flos Chrysanthemi indici --- essential oil --- extraction method --- chemical composition --- biological activity --- Garcinia linii --- hypoglycemia --- benzopyran --- triterpene --- bioflavonoid --- phenolic --- in silico --- neurodegenerative diseases --- naringenin --- pharmacological targets --- signaling pathways --- molecular mechanisms --- drug delivery systems --- luteolin --- hyphenated techniques --- chromatography --- colorectal cancer --- diterpenes --- inflammatory bowel diseases --- Polyalthia longifolia --- herbal medicine --- DESs --- preparative-scale purification --- flavonoids --- 20-hydroxyecdysone --- Chenopodium quinoa --- Zinc oxide nanoparticles --- anticancer --- antileishmanial --- antimicrobial --- biocompatibility --- cancer --- apoptosis --- herbs --- cell lines --- in vivo --- quercetin --- polyphenols --- Alzheimer’s disease --- mechanistic insights --- clinical directions --- isodon genus --- ent-kaurane diterpenoids --- natural compounds --- pathways --- medicinal plants --- bioactive compounds --- 4-hydroxynonenal --- deleterious effects --- Asiatic acid --- nasopharyngeal cancer --- cisplatin resistance --- MAPK pathway --- Anthocyanin --- Solanum nigrum L. --- flavonoid biosynthesis --- AtPAP1 --- licochalcone D --- non-small cell lung cancer --- reactive oxygen species --- Acorus gramineusand --- Euodia ruticarpa --- pro-/anti-inflammatory cytokines --- steam distillation essential oil --- Th1/Th2 cytokines --- lignans --- Trachelospermum asiaticum --- GNPS --- targeted isolation --- Rheum undulatum --- Glycyrriza uralensis --- hepatic encephalopathy --- MMP-9 --- neuroinflammation --- luteolin-7-O-glucoside --- oral cancer --- migration --- invasion --- MMP-2 --- Astragalus mongholicus --- ultraviolet-B radiation --- phenolics --- untargeted gas chromatography-mass spectrometry --- targeted liquid chromatography-mass spectrometry --- Bacopa monnieri --- cheminformatics --- neurological diseases --- spinocerebellar ataxia --- system pharmacology --- (-)-epigallocatechin-3-gallate (EGCG) --- bone morphogenetic protein-2 (BMP-2) --- catethin --- fracture healing --- local use --- cardiovascular diseases --- inflammation --- lipid metabolism --- non-coding RNA --- oxidative stress --- phenolic compounds --- Peucedanum ostruthium --- Apiaceae --- ELINA --- HetCA, STOCSY --- coumarines --- NF-ĸB --- VCAM-1 --- E-selectin --- Withaferin A --- matrix metalloproteinases --- antioxidant signaling --- Curcuma aromatica --- sesquiterpene --- anti-inflammatory --- luciferase assay --- cytotoxicity --- n/a --- Alzheimer's disease