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This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.

Research & information: general --- Biology, life sciences --- Biochemistry --- protein lysine methylation --- H3K9 methylation --- PKMT --- enzyme specificity --- enzyme regulation --- heterochromatin --- protein post-translational modification --- NSD3 --- WHSC1L1 --- structure and function --- protein arginine methylation --- PRMT7 --- epigenetics --- cancer --- immunity --- pluripotency --- SETDB1 --- methyltransferase --- schizophrenia --- Huntington’s disease --- Rett syndrome --- Prader–Willi syndrome --- congenital heart diseases --- inflammatory bowel disease --- MLL2 --- structure --- H3K4me3 --- chromatin regulation --- disease --- dystonia --- NSD1 --- H3K36 --- SOTOS --- NUP98-NSD1 --- AML --- PRMT6 --- post-translational modification --- H3R2me2a --- SETD3 --- posttranslational modifications --- protein histidine methylation --- actin --- polymerization --- cytoskeleton --- enteroviruses --- oncogenesis --- PRMT5 --- cardiovascular disease --- neurodegenerative diseases --- diabetes --- inflammation --- G9a --- GLP --- EHMT2 --- EHMT1 --- post translational modification --- lysine methylation --- N-terminal methylation --- translation --- eEF1A --- METTL13 --- neuron --- synapse --- dendritic spine --- actin cytoskeleton --- GTPase --- PRMT1 --- arginine methylation --- H4R3 methylation --- transcriptional regulation --- cell signaling --- DNA damage repair --- PRMT2 --- SH3 --- SETMAR --- Metnase --- H3K36me2 --- Hsmar1 --- non-homologous end joining repair --- NHEJ --- transposase --- transposable elements --- histone --- SET7/9 --- SETD7 --- lysine-specific methyltransferase (PKMT) --- cell proliferation --- stress response --- post-translational protein modification --- n/a --- Huntington's disease --- Prader-Willi syndrome

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.

Research & information: general --- Biology, life sciences --- Biochemistry --- protein lysine methylation --- H3K9 methylation --- PKMT --- enzyme specificity --- enzyme regulation --- heterochromatin --- protein post-translational modification --- NSD3 --- WHSC1L1 --- structure and function --- protein arginine methylation --- PRMT7 --- epigenetics --- cancer --- immunity --- pluripotency --- SETDB1 --- methyltransferase --- schizophrenia --- Huntington's disease --- Rett syndrome --- Prader-Willi syndrome --- congenital heart diseases --- inflammatory bowel disease --- MLL2 --- structure --- H3K4me3 --- chromatin regulation --- disease --- dystonia --- NSD1 --- H3K36 --- SOTOS --- NUP98-NSD1 --- AML --- PRMT6 --- post-translational modification --- H3R2me2a --- SETD3 --- posttranslational modifications --- protein histidine methylation --- actin --- polymerization --- cytoskeleton --- enteroviruses --- oncogenesis --- PRMT5 --- cardiovascular disease --- neurodegenerative diseases --- diabetes --- inflammation --- G9a --- GLP --- EHMT2 --- EHMT1 --- post translational modification --- lysine methylation --- N-terminal methylation --- translation --- eEF1A --- METTL13 --- neuron --- synapse --- dendritic spine --- actin cytoskeleton --- GTPase --- PRMT1 --- arginine methylation --- H4R3 methylation --- transcriptional regulation --- cell signaling --- DNA damage repair --- PRMT2 --- SH3 --- SETMAR --- Metnase --- H3K36me2 --- Hsmar1 --- non-homologous end joining repair --- NHEJ --- transposase --- transposable elements --- histone --- SET7/9 --- SETD7 --- lysine-specific methyltransferase (PKMT) --- cell proliferation --- stress response --- post-translational protein modification

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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.

Research & information: general --- arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer's --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer's disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β