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Phenolic compounds are an extremely diverse class of ubiquitous secondary metabolites produced by a variety of organisms playing different biological roles. They have numerous types of demonstrated bioactivities, including antioxidant, antimicrobial, anti-inflammatory, antitumoral, immunomodulator, neuroprotective, cardioprotective, and antidiabetic activities. Marine organisms produce a vast collection of unique phenolic structures, some of them not found in terrestrial habitats. Progress in different aspects is rapidly advancing, and this Special Issue will provide updated information and recent studies on marine phenolics. Specially, this issue is focused on their chemical characterization, elucidation of their structures, evaluation of their biological properties and mechanisms of action, efficient extraction and purification technologies, development of value-added applications, as well as formulation of novel products.

Research & information: general --- Biology, life sciences --- Food & society --- ultrasound assisted extraction --- conventional extraction --- polyphenols --- phlorotannin --- macroalgae --- antioxidant capacity --- seaweeds --- antioxidant potential --- LC-ESI-QTOF-MS/MS --- HPLC-PDA --- seaweed polyphenols --- hypoglycemic effect --- starch digestion --- enzyme inhibition --- cochayuyo --- seaweed polyphenolics --- polyphenolics extractions --- phlorotannins --- bromophenols --- flavonoids --- phenolic terpenoids --- polyphenolics bioactivities --- marine phenolics --- emerging technologies --- extraction --- Ascophyllum --- seaweed --- health benefits --- isomers --- LC-MSn --- diversity --- phenolics --- simple phenolics --- seawater --- algae --- seagrass --- biological activity --- brown seaweeds --- microwave-assisted extraction --- response surface methodology --- antioxidant --- antiradical activity --- xanthine oxidase --- α-glucosidase

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This reprint is a continuation of our previous reprint “Sustainable agricultural, biological, and environmental engineering applications” [ISBN 978-3-0365-2921-9], which was published in January 2022. The reprint contains research and review works focused on agricultural engineering technologies and applications. In this regard, the reprint covers topics including agricultural storage, quality evaluation of fruits, evaporative cooling and desiccant systems, solar coffee roasting, solar yogurt processing, greenhouse environment, greenhouse ventilation, greenhouse thermal requirements, aquaculture production system, bioreactor landfill, waste management, fertilization reduction in agriculture, sustainable porous surfaces, simulation and modeling, artificial intelligence, and machine learning. Such agricultural engineering studies are urgently needed in the 21st century, particularly from the perspective of the agriculture–energy–food security nexus.

Research & information: general --- Biology, life sciences --- Technology, engineering, agriculture --- greenhouse --- microclimate --- Bayesian optimization --- deep neural network --- roses yield --- Gaussian process --- gradient boosting --- pool boiling heat transfer coefficient --- sintered coated porous surfaces --- gaussian process --- gradient boosting regression trees --- response surface --- renovation index --- CFD simulation --- airflow --- evaporative cooling --- desiccant dehumidification --- agricultural storage --- air conditioning --- system performance --- lemon cordial --- microwave --- preservation --- green processing --- antioxidant potential --- renewable energy --- Scheffler concentrator reflector --- batch-type solar roaster --- response surface methodology --- coffee roasting --- municipal solid waste --- sanitary landfill --- open dumps --- waste to energy --- climate change --- yogurt processing --- solar energy --- solar-based heating and cooling --- thermal analysis --- vegetable yield --- nitrogen use efficiency --- nutrient leaching --- leaching-to-input ratio --- nitrogen fertilizer economic benefit --- environment --- eutrophication --- particulate fraction --- effluent --- treatment --- thermal screens --- heating demand --- TRNSYS --- greenhouse internal temperature --- building energy simulation --- longwave radiation --- soil total nitrogen --- BP neural network --- support vector machines --- spatial distribution --- remote sensing

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The development of new foods or nutraceuticals with health benefits is among today’s most important issues, which presents an opportune moment for the food and/or pharmaceutical industries. However, the launch of new products should be supported by strong scientific evidence on the health benefits attributable to the intake of these bioactive food ingredients. Studies focusing on changes during the storage conditions, digestion process, intestinal absorption rates, biological mechanisms of action, or bioactivity of their metabolites are also required to establish the real contribution of these compounds to the health status of today’s societies

phytochemicals --- antioxidant --- antinausea --- antiobesity --- anticancer --- anti-inflammatory --- ‘Cara Cara’ juice --- storage --- hydrophilic and lipophilic antioxidant --- carotenoid --- flavonoid --- degradation --- dried distilled spent grain (DDSG) --- melanoidins --- content --- structure --- antioxidant activity --- ACE-inhibitory activity --- beverages --- brewing method --- antioxidant potential --- total polyphenols content --- mineral composition --- grape stem --- phenolic compounds --- central composite rotatable design --- sustainable food systems --- pressurized liquid extraction --- side streams valorisation --- curcumin --- milk proteins --- nanoparticles --- antimicrobial activities --- bioactive peptides --- hypertension --- functional food --- metabolic syndrome --- microbiota --- insulin sensitivity --- polyphenols --- grape pomace --- donkey milk (DM) --- donkey colostrum (DC) --- mammal’s milk --- cow’s milk protein allergy (CMPA) --- biologic activity --- immunosenescence --- health benefits --- cryoconcentration --- calafate juice --- storage time --- physicochemical properties --- bioactive compounds --- sensorial analysis --- apitherapy --- royal jelly --- propolis --- bee pollen --- sarcopenia --- dietary interventions --- muscle --- skeletal --- muscle wasting --- physical performance --- coronavirus disease 2019 --- COVID-19 --- body composition --- lean body mass --- insulin resistance --- mitochondrial dysfunction --- satellite stem cells --- polysaccharide purification --- anti-obesity --- proliferation --- PPARγ --- biological activities --- isolation --- analysis --- mechanism of action --- bioaccessibility --- intestinal absorption --- bioavailability

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Phytotherapy is probably the oldest form of medicine; however, it represents a new therapeutic tool for healthcare workers. Indeed plants are an infinite source of novel molecules, with countless possible combinations. This collection of articles (a Special Issue from Molecules) brings together the most up-to-date studies on the use of plant-derived compounds, ranging from their anti-inflammatory, antioxidant, and anticancer effects to the revision of the prominent literature.

Medicine --- natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma

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This Special Issue provides recent advances in the use of plants for therapeutic purposes. This Special Issue collected the plants, including leaf, fruit, and others. This Special Issue's targets were crude plant extract and active principle purified from the plant. This Special Issue prompted researchers to provide each plant discovery. We are pleased to include in this Special Issue the screened Mexican plants and the halophytic plants growing in central Saudi Arabia, and so on. As a result, we have sparked scientists' interest in studying the plant for therapeutic purposes. This field necessitates network pharmacology analysis and machine-aided learning. Many disorders resistant to modern medication are looking for active principles isolated from the plants all over the world.

Medicine --- Pharmacology --- safflower --- hydroxysafflor yellow A --- safflower yellow A --- flavonoid --- platelet aggregation --- vescalagin --- methylglyoxal --- inflammation --- antioxidant --- insulin secretion --- traditional medicine --- hypoglycemic plants --- Eryngium longifolium --- Alsophila firma --- glucose 6-phosphatase --- fructose 1,6-bisphosphatase --- Lycium shawii --- Anabasis articulata --- Rumex vesicarius --- Zilla spinosa --- anticancer --- antimicrobial --- biogenetic interrelationship --- flavonoid contents --- trace elements --- human tumor cell lines --- cytotoxic effect --- plant extracts --- Acalypha monostachya --- Lindera obtusiloba --- apolipoprotein E-deficient mice --- atherosclerosis --- endothelium --- black bean soybean sauce --- by-product --- functional supplements --- Moringa oleifera --- anti-aging --- fibrosis --- kidney disease --- Gan-Mai-Da-Zao --- depression --- brain-derived neurotrophic factor --- serotonin transporter --- unpredictable chronic mild stress --- Acalypha arvensis --- ellagitannin --- corilagin --- Staphylococcus aureus --- flavonoids --- antibacterial --- Alzheimer’s disease --- amyloid β --- immunomagnetic reduction --- Drosophila melanogaster --- water extract of fermented rice bran --- non-alcoholic fatty liver disease --- high-fat diet --- aged rat --- Salvia haematodes --- rapid solid–liquid dynamic extraction (RSLDE) --- extractor Naviglio® --- Soxhlet apparatus --- medium pressure liquid chromatography (MPLC) --- antioxidant potential --- Inga jinicuil --- phytochemical profile --- HPLC-PDA --- GC-MS --- anti-inflammatory --- fast dissolving films --- yeast β-glucan --- bilberry juice --- diabetes --- herbal medicine --- bioactive derivative --- triple negative breast cancer --- Wnt/β-catenin --- anti-cancer --- n/a --- Alzheimer's disease --- rapid solid-liquid dynamic extraction (RSLDE)