Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Malignant mesothelioma (MM) is a rare and aggressive cancer, related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos. Although this mineral has been banned for decades in many countries, epidemiologists predict the MM epidemic will last past 2040, raising many concerns in public health given its late diagnosis, dismal prognosis, and lack of current efficient therapies.To deal with this situation, important breakthroughs have recently been made in the understanding of MM’s complex biology and the carcinogenic process of the different patterns of the disease. Examples of these include the development of new biomarkers and the deciphering of gene–environment interactions, molecular mechanisms of invasiveness, deregulated pathways, altered expression of miRNAs, DNA damage repair, or metabolic profile. From now on, MM’s aggressive and chemoresistant character appears linked to a polyclonal malignancy, and heterogeneity in molecular alterations.Given these improvements, new therapeutic targets are being explored to solve the double challenge faced by clinicians. The first is to reduce tumor development and its wasting consequences as soon as possible, without resistance and with limited toxicity. The second is to stimulate the recognition of tumor cells by the induction of a specific immune response. This Special Issue will highlight all these aspects.

well-differentiated papillary mesothelioma --- WDPM --- malignant mesothelioma --- DNA sequencing --- mutation --- mesothelioma --- tumor suppressor --- targeted therapy --- immunotherapy --- biomarkers --- proteomics --- macrophage-capping protein --- fatty acid-binding protein --- laminin subunit beta-2 --- selenium-binding protein 1 --- carcinogenesis --- malignant pleural mesothelioma --- asbestos exposure --- DNA methylation --- lymphocyte-to-monocyte ratio --- epigenome-wide analysis --- survival analysis --- metabolomics --- radiotherapy --- cancers --- inflammation --- infiltrating immune cells --- prognostic biomarker --- predictive biomarker --- immune therapy --- VATS --- extrapleural pneumonectomy --- pleurectomy decortication --- therapy response --- survival --- FDG --- PET-CT --- mesothelium --- oxidative stress --- redox-sensitive factors --- asbestos --- carbon nanotubes --- protein-protein interactions --- systems biology --- network analysis --- drug repurposing --- pleural mesothelioma --- gene expression --- immunogenicity --- sarcomatoid --- epithelioid --- first line --- meta-analysis --- systematic review --- MPM --- lurbinectedin --- DNA damage response --- histotype --- Hippo pathway --- NF2 --- BAP1 --- CDKN2A --- PTCH1 --- SETD2 --- MTAP --- liquid biopsies --- circulating tumor DNA --- plasma --- cancer-specific mutations --- genomics --- cancer biomarkers --- tumor microenvironment --- tumor-associated macrophages --- dendritic cells --- immunohistochemistry --- interaction analysis --- pleural effusion --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Minimally invasive surgery has become a common term in visceral as well as gynecologic surgery. It has almost evolved into its own surgical speciality over the past 20 years. Today, being firmly established in every subspeciality of visceral surgery, it is now no longer a distinct skillset, but a fixed part of the armamentarium of surgical options available. In every indication, the advantages of a minimally invasive approach include reduced intraoperative blood loss, less postoperative pain, and shorter rehabilitation times, as well as a marked reduction of overall and surgical postoperative morbidity. In the advent of modern oncologic treatment algorithms, these effects not only lower the immediate impact that an operation has on the patient, but also become important key steps in reducing the side-effects of surgery. Thus, they enable surgery to become a module in modern multi-disciplinary cancer treatment, which blends into multimodular treatment options at different times and prolongs and widens the possibilities available to cancer patients. In this quickly changing environment, the requirement to learn and refine not only open surgical but also different minimally invasive techniques on high levels deeply impact modern surgical training pathways. The use of modern elearning tools and new and praxis-based surgical training possibilities have been readily integrated into modern surgical education,which persists throughout the whole surgical career of modern gynecologic and visceral surgery specialists.

ovarian cancer --- laparoscopy --- minimally invasive surgery --- survival --- mortality --- platelet-rich plasma (PRP) --- thin endometrium --- hysteroscopy --- robotic surgery --- sexuality --- laparoscopic hysterectomy --- learning curve --- quality of life --- counseling --- patient-doctor-relationship --- body donors --- surgical education --- clinical anatomy --- live surgery events --- neuropelveology --- LION procedure --- genital nerves stimulation --- chronic pelvic pain --- esophagectomy --- esophageal cancer --- Ivor-Lewis procedure --- health-related quality of life --- cervical cancer --- robotic radical hysterectomy --- recurrence rate --- surgery --- artificial intelligence --- machine learning --- augmented reality --- hysterectomy --- NOTES --- minimally invasive --- systematic review --- meta-analysis --- pediatric surgery --- fetal surgery --- single-incision surgery --- surgical techniques --- surgical devices --- open surgery --- endoscopy --- endoscopic surgery --- cysts of the canal of Nuck --- Nuck hydrocele --- hydrocelectomy --- TAPP --- Lichtenstein --- colorectal liver metastases --- laparoscopic liver surgery --- minimal invasive surgery --- general anesthesia --- anesthetics --- perioperative care --- laparoscopic surgery --- endometrial cancer --- lymphadenectomy --- embryology --- sentinel lymph node mapping --- indocyanine green --- PMMR --- technical aspects --- rectal cancer --- mesorectal --- transanal --- laparoscopic --- local recurrence --- conversion rate --- minimally invasive surgical procedures --- radiotherapy --- ovarian neoplasms --- endometrial neoplasms --- uterine cervical neoplasms --- vaginal neoplasms --- vulvar neoplasms --- survival analysis --- n/a --- video feedback --- video modeling --- gynecology --- surgical training --- pelvitrainer --- prolapse --- pelvic floor --- native tissue --- pectopexy --- robotic assisted surgery --- pancreatic surgery --- pancreaticoduodenectomy --- pelvic floor repair --- laparoscopic repair --- vaginal repair --- mesh use --- VATS --- pain --- postoperative pain control --- thoracic surgery --- lung cancer --- intercostal catheter --- opioid --- regional anaesthesia --- hepatectomy --- single-port laparoscopy --- radiofrequency pre-coagulation --- endometriosis --- endometrioma surgery --- ovarian reserve --- anti-Müllerian hormone --- spontaneous pregnancy --- robotic liver resection --- da Vinci --- intraoperative imaging --- hepatocellular cancer --- real-life imaging --- hepatic metastasis --- COVID-19 --- sars-cov-2 --- surgical performance --- 3D printing --- skill assessment --- snorkel mask --- malabsorption --- Roux-en-Y gastric bypass --- one-anastomosis gastric bypass --- SADI-S --- biliopancreatic diversion --- weight regain --- hepatocellular carcinoma --- cholangiocarcinoma --- risk score --- pelvic compartments --- embryologic development --- oncologic surgery --- pelvic lymphonodectomy --- topographic anatomy --- autonomic pelvic nerves --- uterine cancer --- prostate cancer --- diaphragmatic hernia --- liver resection --- hernia repair --- mesh --- enterothorax --- anti-Müllerian hormone