Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

TRP channels.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a "hot" new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.

TRP channels.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

TRP channels.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could

Human physiology --- TRP channels. --- Transient receptor potential channels --- TRP proteins --- Ion channels --- Membrane proteins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Contents A. Verkhratsky, R. C. Reyes, and V. Parpura TRP Channels Coordinate Ion Signalling in Astroglia. A. Nürnberg, A. Kollmannsperger, and R. Grosse Pharmacological Inhibition of Actin Assembly to Target Tumor Cell Motility.   C. A. Goodman The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli.

Human physiology. --- Biochemistry. --- Pharmacology. --- TRP channels. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Human biology --- Physiology --- Human body --- Physiological effect --- Transient receptor potential channels --- TRP proteins --- Ion channels --- Membrane proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Toxicology. --- Oncology. --- Human Physiology. --- Pharmacology/Toxicology. --- Cancer Research. --- Tumors --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Cancer research. --- Cancer research