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This volume of the treatise deals with structural aspects of the cytoskeleton: the characteristics of the filaments and their components; the organization of the genes; motor proteins; interactions with membranes.

Cytoskeleton. --- Cell skeleton --- Skeleton, Cell --- Cytoplasm

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The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with ""motility"" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Cytoskeleton. --- Cell skeleton --- Skeleton, Cell --- Cytoplasm --- Life Sciences --- Microbiology --- Genetics and Molecular Biology --- Cytology --- Biochemistry

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This book provides a comprehensive overview of the state-of-the-art methodology to investigate how actin (and actinlike) microfilaments and microtubules work to accomplish different cellular functions in different cellular contexts from bacteria to humans. The book covers extensive and exciting methodologies for protein purification and in vitro reconstitution of several cytoskeleton properties, as well as the functional dissection of microtubule- and actin-based structures, such as centrioles, mitotic spindles, axons, and cytokinetic contractile rings. It also provides a methodology for the study and manipulation of microtubules and actin, including the study of their nucleation, ultrastructural and/or dynamic properties (e.g., using optogenetics), and the functional dissection of post-translational modifications. There is a focus on specific biological processes, inevitably on mitosis, but also on bacterial division, meiosis, cytokinesis, axonal transport, and nuclear migration.

Cytoskeleton. --- Cell physiology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cell function --- Cytology --- Physiology --- Cell skeleton --- Skeleton, Cell --- Cytoplasm

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Cytoplasmic Filaments --- Cytoskeleton --- Cytosquelette --- Life Sciences --- Biology --- Cytoskeleton. --- Cytoplasmic Filaments. --- Cytology --- Cell skeleton --- Skeleton, Cell --- Cytoplasm --- cell walls --- cytoplasm --- Cellular Biology --- Cytology.

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Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics  and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on  "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

Cytoskeleton --- Research. --- Cell skeleton --- Skeleton, Cell --- Medicine. --- Pharmacology. --- Cell physiology. --- Biomedicine. --- Pharmacology/Toxicology. --- Cell Physiology. --- Cytoplasm --- Toxicology. --- Cell function --- Cytology --- Physiology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect