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Immunology. Immunopathology --- immunology (XIV.) --- Sect --- Prim --- Binding sites (Biochemistry) --- Cell membranes --- Lymphocytes --- Active site (Biochemistry) --- Bonding sites (Biochemistry) --- Reactive site (Biochemistry) --- Biochemistry --- Immunoglobulin idiotypes --- Immunospecificity --- Congresses

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This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.

Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Antigen-antibody reactions. --- Immunospecificity. --- Binding sites (Biochemistry) --- Active site (Biochemistry) --- Bonding sites (Biochemistry) --- Reactive site (Biochemistry) --- Immunological specifics --- Serological specificity --- Specificity (Immunology) --- Antibody-antigen reactions --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Biomedicine. --- Medical Microbiology. --- Biochemistry --- Immunoglobulin idiotypes --- Immunospecificity --- Antibody diversity --- Antigenic determinants --- Immune recognition --- Antigens --- Immune response --- Immunoglobulins --- Immunology --- Microbiology. --- Medical virology. --- Medical microbiology --- Virology --- Virus diseases --- Microbial biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Microbiology

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Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest. This book is primarily targeted to researchers and graduate students in the fields of molecular pharmacology, receptors, receptor biology, and signal transduction. These courses are variously found in pharmacology, molecular and cell biology, biochemistry and neuroscience. Researchers in the pharmaceutical industry working on bringing new drugs to market will also find this book useful.

Cell receptors. --- Binding sites (Biochemistry) --- Récepteurs cellulaires. --- Sites actifs (Biochimie) --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Cell membranes --- Proteins --- Active site (Biochemistry) --- Bonding sites (Biochemistry) --- Reactive site (Biochemistry) --- Biochemistry --- Immunoglobulin idiotypes --- Immunospecificity --- Toxicology. --- Cytology. --- Biochemistry. --- Medicine. --- Neurosciences. --- Pharmacology/Toxicology. --- Cell Biology. --- Biochemistry, general. --- Molecular Medicine. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Toxicology --- Composition --- Health Workforce --- Recepteurs cellulaires.

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Binding sites (Biochemistry) --- Immunospecificity --- Antigen-Antibody Reactions --- Binding Sites, Antibody --- Cell Biology. --- Immunoglobulins --- Cellular Biology --- Cytology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Antibody Binding Sites --- Paratopes --- Antibody Binding Site --- Binding Site, Antibody --- Paratope --- Immunoglobulin Variable Region --- Antigen Antibody Reactions --- Antigen-Antibody Reaction --- Reaction, Antigen-Antibody --- Reactions, Antigen-Antibody --- AC133 Antigen --- Antibodies --- Antigens --- Immunological specifics --- Serological specificity --- Specificity (Immunology) --- Antibody diversity --- Antigenic determinants --- Immune recognition --- Active site (Biochemistry) --- Bonding sites (Biochemistry) --- Reactive site (Biochemistry) --- Biochemistry --- Immunoglobulin idiotypes --- Immunoglobulin --- Globulins, Immune --- Immune Globulin --- Immune Globulins --- Globulin, Immune --- Genes, Immunoglobulin --- Congresses --- Immunology. Immunopathology --- Cell Biology

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Molecular biology --- Nucleic acids --- Binding sites (Biochemistry) --- Biochemical genetics --- Proteins --- Molecular Biology --- Binding Sites --- Nucleic Acides --- Congresses --- Nucleic Acids. --- Proteins. --- Binding Sites. --- Molecular Biology. --- -Biochemical genetics --- -Nucleic acids --- -Proteins --- -Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Polynucleotides --- Chemical genetics --- Biochemistry --- Molecular genetics --- Active site (Biochemistry) --- Bonding sites (Biochemistry) --- Reactive site (Biochemistry) --- Immunoglobulin idiotypes --- Immunospecificity --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Binding Site --- Combining Site --- Combining Sites --- Site, Binding --- Site, Combining --- Sites, Binding --- Sites, Combining --- Protein Binding --- Protein Interaction Mapping --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Acids, Nucleic --- Congresses. --- Genetic Phenomena --- -Congresses --- Nucleic Acids --- Protein --- Nucleic Acid --- Acid, Nucleic --- Nucleic acids - Congresses --- Binding sites (Biochemistry) - Congresses --- Biochemical genetics - Congresses --- Proteins - Congresses --- Molecular Biology - congresses --- Binding Sites - congresses --- Proteins - congresses --- Nucleic Acides - congresses