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Asthma --- Rhinovirus --- Common Cold --- Bronchial Hyperreactivity --- metabolism --- physiology --- complications

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Rhinovirus Infections: Rethinking the Impact on Human Health and Disease provides a timely review of the impact of rhinovirus infections on human health. It identifies disease mechanisms relating to the virus, human host and environmental factors. This viewpoint allows us to look forward to the development of treatments for a virus for which treatment options are currently non-existent. By providing detailed insights into this virus, its host and the environmental factors that play into rhinovirus induced diseases, this book explains disease mechanisms and summarizes existing and developing therapeutic approaches for better research, diagnosis and potential treatments.--

Hygiene. Public health. Protection --- Virus diseases. --- Rhinoviruses. --- Rhinovirus. --- Picornaviridae Infections. --- Public health. --- Picornavirus infections. --- Virus Diseases. --- Publlic Health.

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rotavirus --- virologie --- medische virologie --- biologie --- therapie --- rhinovirus --- rehydratatie --- Medical microbiology, virology, parasitology --- paramoxyvirus --- adenovirus --- enterovirus --- poxvirussen --- geneeskunde --- hepatitisvirussen --- virussen (biologie) --- Microbiologie --- Academic collection

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Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.

hematopoietic cells --- DEPArray --- n/a --- neuroblastoma --- liver steatosis --- MAPK phosphatase --- DUSP-4 --- granule neurons --- neuronal differentiation --- DUSP10 --- cytokines --- MAPKs --- single cell analysis --- macrophage --- asthma --- E. coli infection --- MAPK --- Cpp1 --- nucleotide receptors --- atypical DUSP --- RSV --- Pmp1 --- cannabinoids --- astrocytes --- sepsis --- influenza --- signaling --- triple-negative breast cancer (TNBC) --- differentiation --- HDAC6 (histone deacetylase isoform 6) --- atypical dual-specificity phosphatases --- microtubules --- respiratory viruses --- MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) --- dual-specificity phosphatase --- Msg5 --- TLR signaling --- mitogen-activated protein kinase --- fungal MKPs --- macrophages --- MAP Kinase Phosphatase-2 --- inflammation --- Sdp1 --- circulating tumor cells (CTCs) --- MAP kinases --- MAP kinase phosphatases --- P2X7 --- proliferation --- BDNF --- P2Y13 --- T cell --- hypertriglyceridemia --- integrated omics analysis --- post-translational modification --- rhinovirus --- protein stability --- ubiquitination --- dual-specificity phosphatases --- Mkp-1 --- cancer --- brain metastasis --- HER2 --- COPD --- pseudophosphatase

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On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 presents significant challenges to health systems and public health in both hemispheres as well as to the economies of each country. The morbidity and mortality due to infections caused by SARS-CoV-2 have been significant despite the short duration since its discovery and initially overwhelmed many hospitals and clinics. It influences everyone, and countermeasures have been dramatic in their impact on employment, social systems, and mental health. This Special Issue provides an avenue for authors from various disciplines to provide feedback on our responses and preparedness to COVID-19 globally as well as to disseminate critical information about the SARS-CoV-2 virus and the associated COVID-19 pandemic. It consists of 22 peer-reviewed papers that cover worldwide perspectives encompasses the following: Original articles about COVID-19 (including epidemiology, modelling, clinical data, treatment, prevention, countermeasures, impacts on tropical regions, response, and preparedness);Original articles about SARS-CoV-2 (microbiology, virology, transmission, pathology, and vaccinology);Perspectives about COVID-19 and SARS-CoV-2 (comparisons with past coronavirus outbreaks, impactful local initiatives, novel responses, and commentaries);Reviews on COVID-19 (based on systematic and narrative reviews);and Innovations (vaccine development, drug trials, and original countermeasures).

COVID-19 --- SARS-CoV-2 --- hepatitis B and C --- cirrhosis --- chronic kidney disease --- alcohol-related liver disease --- nonalcoholic steatohepatitis --- necrosis --- MDR-TB --- clinical trials --- IL-6 inhibitors --- tocilizumab --- cytokine release syndrome --- cytokine storm --- operational research --- health systems --- SORT IT --- pandemics --- training --- pandemic --- endemic --- tuberculosis --- impact --- control --- overview --- malaria --- preparedness --- Africa --- emergency --- fecal calprotectin --- bowel perforation --- D-Dimer --- thrombosis --- ischemia --- efficacy --- safety --- kaletra --- lopinavir/ritonavir --- meta-analysis --- coronavirus --- SARS-CoV-1 --- MERS --- SARS --- influenza --- healthcare worker --- healthcare personnel --- general practitioners --- medical doctor --- heart transplant --- CMV --- Chagas disease --- infection --- severity --- respiratory viruses --- coinfections --- health care workers --- Philippines --- rhinovirus --- severe acute respiratory syndrome coronavirus 2 --- plasmodium falciparum --- differential diagnosis --- cognitive bias --- diagnostic reasoning --- recurrence --- reinfection --- Bangladesh --- Kenya --- Nairobi --- presumptive tuberculosis --- TB treatment outcomes --- HIV --- antiretroviral therapy --- EpiCollect5 --- Malawi --- Lilongwe --- Zimbabwe --- Harare --- real-time operational research --- ethics --- research capacity building --- India --- Nepal --- post-acute COVID-19 syndrome --- COVID-19 vaccines --- mortality --- epidemiology --- public health --- healthcare workers --- attitudes --- perceptions --- knowledge --- n/a