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The SecretoryPathway The transport ofproteins and lipids from their site ofsynthesis at the endoplasmic reticu­ lum (ER) to the cellsurface ismediated by the secretory pathway and isan essential process in eukaryotic organisms. A great variety ofmolecules are extruded from cellsby the action ofthe secretory pathway, including extracellular matrix components that provide the foundation for constructing tissuesand organs. Moreover, this pathway playsa major role in the biogenesisof the plasma membraneand itsexpansion before celldivision. Therefore, withoutsecretion there would be no cells,tissuesor organs, and so it issafeto saythat we oweourvery existence to the secretory pathway. To understand the process ofsecretion we must learn about the organelles that compose the secretory pathway; the ER and Golgi apparatus, and the transport vesicles these or­ ganelles produce. The membrane ofthese organelles is primarily synthesized and assembled at the ER but with contributions from mitochondria (phosphatidylethanolamine) and the Golgi apparatus (sphingolipids). Newly synthesized proteins destined for secretion gain en­ try into the secretory pathway by translocation across the ER membrane. This translocation apparatus also integrates proteins into the membrane and establishes their topology with respect to the lipid bilayer (seeChapter 7). Many secretory proteins are covalently modified with oligosaccharides to produce glycoproteins, a biosynthetic process initiated in the ER and continued in the Golgi apparatus. Once proteins are properly folded and modified in the ER, they are allowed to leave and are ushered into COPlI-coated carrier vesiclesforming at specific exit sites (see Chapters 1 and 8).

Proteins --- Physiological transport.

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Membrane proteins --- Physiological transport. --- Membranes (Biology) --- Proteins --- Physiological transport

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Iron --- Physiological transport --- Metabolism --- Disorders

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Mixed ionic-electronic conducting (MIEC) ceramics as oxygen transport membranes (OTMs) can provide high oxygen permeation rates at comparably low energy demands. For this purpose, Ba₀.₅Sr₀.₅Co₀.₈Fe₀.₂O₃₋δ (BSCF) shows the best performance under ideal operating conditions. Thermal and chemical stability investigations, electrical behavior σ(T,pO₂,t), and oxygen exchange parameter extraction by means of electrical conductivity relaxation resulted in a far better understanding of the BSCF system.

Oxygen --- Physiological transport. --- Therapeutic use.

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Estrogen --- Livestock --- Environmental aspects --- Physiological transport --- Metabolism