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This dissertation by Leif B.G. Johansson explores the development and application of luminescent conjugated oligothiophenes (LCOs) as molecular probes for studying protein aggregation diseases, notably amyloid-related conditions. The work highlights the advantages of LCOs over traditional dyes like Congo red and Thioflavin T, emphasizing their ability to detect early-stage protein aggregates and distinguish different aggregate morphologies. The research incorporates novel techniques such as Surface Plasmon Resonance (SPR) and Positron Emission Tomography (PET) to study the interactions between LCOs and amyloid fibrils in real-time. The thesis also discusses the synthesis of asymmetrical LCOs and the role of molecular modifications in enhancing binding specificity and sensitivity. This work is intended for researchers in chemistry and biomedical sciences focusing on molecular diagnostics and therapeutic developments in protein aggregation diseases.

Conjugated oligomers. --- Amyloidosis. --- Conjugated oligomers --- Amyloidosis

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POLYPHENYLS --- OLIGOMERS --- LUMINESCENCE

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Photovoltaic power generation. --- Oligomers. --- Copolymers.

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Liquid chromatography --- Oligomers --- Chromatographie en phase liquide --- Analysis.

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"Carbohydrate Polymer Technologies and Applications is an open access scholarly journal devoted to scientific and technological aspects and applications of polymers and oligomers containing carbohydrate. ... Carbohydrate Polymer Technologies and Applications will cover most polymers and oligomers containing carbohydrate, including carbohydrate polymers, cyclodextrins, glycoproteins, glycolipids, dendrimers containing carbohydrate, glycopeptide linkages, glycoproteins, lipopolysaccharides, peptidoglycans and proteoglycans. ... From the molecular point of view, characteristics of the carbohydrate-containing molecule will be paramount covering analysis, molecular weight, structure, physicochemical aspects. Enzymic biodegradation and biosynthesis of carbohydrate-containing molecules will also be covered."--Publisher

Polymers --- Oligomers --- Polymers. --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Polymer --- Oligimers --- organic chemistry --- carbohydrate --- polymer --- oligomer --- biochemistry --- Oligomers. --- Polysaccharides --- Biopolymers --- Bioplastics --- Bioplastic --- Biopolymer --- Glycan --- Glycans --- Polysaccharide