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Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling.

Neuroimaging --- functional MRI --- Neuroglial metabolic coupling --- glutamate-glutamine cycle --- Astrocytic Networks --- Astrocyte-neuron lactate shuttle --- 13C NMR --- Neurovascular coupling

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Intracellular Ca2+ signaling is witnessing an amazing resurgence of interest. In addition to traditional Ca2+ aficionados, an astonishing (and growing) number of colleagues from all around the world have started to devote a large part of their research to gain insights into the role of Ca2+ signaling in health and disease. This is why calcium ions interact with virtually every signal transduction pathway not only in mammalian cells, but also across the phylogenetic tree, thereby, driving or modulating most, if not all, cellular functions, ranging from fertilization to apoptosis, passing through learning and memory, cardiac contractility, and immune response. This book gathers a collection of original research articles and reviews by a number of renowned experts who aim to present the state of the art of many pathophysiological aspects of intracellular Ca2+ signaling, such as embryonic development, immune response, extracellular Ca2+ signaling, neoplastic transformation, muscle hypertrophy, pulmonary inflammation, and P2X receptor gating.

STIM --- intracellular Ca2+ oscillations --- Ca2+ signaling --- 5-trisphosphate receptors --- neurovascular coupling --- cardiac contractility --- inositol-1 --- SERCA --- NMDA receptors --- calcineurin --- Orai --- P2X receptors --- Ca2+-Sensing Receptor --- 4 --- immune response --- cancer --- Ca2+-activated K+ channels --- muscle hypertrophy --- ryanodine receptors

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Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field.

Arteries --- Hemodynamics. --- Hemodynamics --- Diseases. --- Hemodynamic --- Neurovascular Coupling --- Blood Circulation --- Blood --- Cardiac output --- Hydrodynamics --- Circulation --- Elastic properties. --- Arterial elasticity --- Biomechanics --- Elasticity --- Vascular Stiffness --- Pulsatile Flow --- Models, Theoretical --- Vascular Stiffness. --- Pulsatile Flow. --- Models, Theoretical.

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The second edition of this key resource provides a broad and fundamental overview of basic cardiovascular (CV) hemodynamic principles with a focus on clinical assessment of CV physiology. Extensively updated, the book includes new coverage on noninvasive hemodynamic assessment and the effects of selected interventions on CV hemodynamics. It provides an introduction to the basic concepts such as preload, afterload, myocardial contractility, and cardiac output. Subsequent chapters examine the effects of interventions such as vasodilators, beta blockers, pressor agents, inotropes, and different forms of invasive circulatory support. The book also focuses on various methods of hemodynamic evaluation including echocardiography, CT/MRI, noninvasive hemodynamic assessment, and cardiac catheterization. The book concludes with a discussion of proper diagnosis, evaluation, and management of patients using hemodynamic data on a variety of specific disease states. An invaluable contribution to the Contemporary Cardiology Series, the Second Edition of Cardiovascular Hemodynamics: An Introductory Guide is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, emergency medicine, critical care, and internal medicine.

Hemodynamics. --- Cardiology. --- Emergency medicine. --- Emergency Medicine. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Heart --- Internal medicine --- Diseases --- Cardiovascular system --- Cardiovascular Diseases. --- Diseases. --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Hemodynamic --- Neurovascular Coupling --- Blood Circulation --- Cardiovascular diseases --- Blood --- Cardiac output --- Hydrodynamics --- Circulation

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Umbilical Arteries --- Blood Flow Velocity. --- Ultrasonics. --- Fetal Monitoring --- Hemodynamics. --- Hemodynamic --- Neurovascular Coupling --- Blood Circulation --- Ultrasonic --- Ultrasonic Waves --- Blood Flow Velocities --- Flow Velocities, Blood --- Flow Velocity, Blood --- Velocities, Blood Flow --- Velocity, Blood Flow --- physiology. --- methods. --- Theses --- Physiology: reproduction & development. Ages of life --- Blood Flow Velocity --- Ultrasonics --- Hemodynamics --- physiology --- methods