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Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative
Inflammation - Molecular aspects. --- Inflammation -- Molecular aspects. --- Inflammation - Pathophysiology. --- Inflammation -- Pathophysiology. --- Neurogenic Inflammation. --- Neuropeptides. --- Sensory neurons. --- Inflammation --- Sensory neurons --- Neuropeptides --- Neurogenic Inflammation --- Neurologic Manifestations --- Nervous System Diseases --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Diseases --- Pathology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Pathophysiology --- Symptoms and General Pathology --- Pathological Processes --- Processes, Pathologic --- Processes, Pathological --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Nervous System --- Innate Inflammatory Response --- Inflammations --- Inflammatory Response, Innate --- Innate Inflammatory Responses --- Immunity, Innate --- Inflammation, Neurogenic --- Inflammations, Neurogenic --- Neurogenic Inflammations --- Neuroimmunomodulation --- Inflammatory process --- Anti-inflammatory agents --- Brain peptides --- Nerve tissue proteins --- Neurotransmitters --- Peptides --- Neurons --- Immune system --- Endocrine glands --- Aging
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The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research. So far, non of the published books covers all aspects which need to be taken into account when planning and performing a microrray experiment in inflammation research. Normally, for a researcher or clinician doing a microarray experiment it is not enough to have knowledge about microarrays , as the experiment does not start with purified and quality controlled RNA and does not end with signal intensities. Things like appropriate cell sorting techniques, stabilisation and transport of RNA or cells, the knowledge how to deal with whole blood as well as options for automation are crucial for a successful application of microarrays. Moreover these aspects are the main obstacles for transferring microarray based inflammation analysis from bench to bedside and the limiting factors for higher through put as needed in multicenter studies.
Biomedicine. --- Microarrays. --- Immunology. --- Cell Biology. --- Hematology. --- Biotechnology. --- Pharmacology/Toxicology. --- Medicine. --- DNA microarrays. --- Toxicology. --- Cytology. --- Médecine --- Puces à ADN --- Immunologie --- Toxicologie --- Biotechnologie --- Hématologie --- Cytologie --- Inflammation -- Pathophysiology. --- Inflammation -- Physiopathology. --- Oligonucleotide array sequence analysis. --- Inflammation --- DNA microarrays --- Oligonucleotide Array Sequence Analysis --- Gene Expression Profiling --- Microarray Analysis --- Pathologic Processes --- Genetic Techniques --- Molecular Probe Techniques --- Nucleic Acid Hybridization --- Sequence Analysis --- Microchip Analytical Procedures --- Pathological Conditions, Signs and Symptoms --- Investigative Techniques --- Chemistry Techniques, Analytical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Biomedical Engineering --- Pathology --- Health & Biological Sciences --- Medicine --- Pathophysiology --- Pathophysiology. --- DNA biochips --- Microarrays, DNA --- Inflammatory process --- Pharmacology. --- Cell biology. --- Biochips --- Immobilized nucleic acids --- Anti-inflammatory agents --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Chemical engineering --- Genetic engineering --- Haematology --- Internal medicine --- Blood --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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