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Over the last decades, the growing prevalence of insulin resistance has dramatically contributed to the global epidemic of metabolic syndrome, obesity, type 2 diabetes mellitus, and cardiovascular disease. Therefore, there is an unmet need for novel nutritional and pharmacological strategies aimed to prevent or treat insulin resistance and its related comorbidities. This book presents a comprehensive overview of the pathophysiology and clinical consequences of insulin resistance in different settings, describing novel diagnostic biomarkers and molecular targets of this condition.

Insulin resistance.

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INSULIN RESISTANCE

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Over the last decades, the growing prevalence of insulin resistance has dramatically contributed to the global epidemic of metabolic syndrome, obesity, type 2 diabetes mellitus, and cardiovascular disease. Therefore, there is an unmet need for novel nutritional and pharmacological strategies aimed to prevent or treat insulin resistance and its related comorbidities. This book presents a comprehensive overview of the pathophysiology and clinical consequences of insulin resistance in different settings, describing novel diagnostic biomarkers and molecular targets of this condition.

Insulin resistance.

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This doctoral thesis by Åsa Jufvas investigates the role of human adipocytes in the development of type 2 diabetes, focusing on genetic and epigenetic factors. It explores the significance of histone variants and post-translational modifications in chromatin dynamics and their influence on insulin resistance. The research highlights the correlation between obesity, insulin signaling, and epigenetic inheritance, identifying specific histone modifications associated with type 2 diabetes. The study also examines the role of IQGAP1 in insulin resistance, revealing its potential as a link between caveolae and the cytoskeleton in adipocytes. The work aims to enhance the molecular understanding of the epigenetic inheritance of obesity and diabetes, providing insights into metabolic health challenges related to modern lifestyle factors. The intended audience includes medical researchers and professionals interested in diabetes and epigenetics.

Epigenetics. --- Insulin resistance. --- Epigenetics --- Insulin resistance

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Over the last decades, the growing prevalence of insulin resistance has dramatically contributed to the global epidemic of metabolic syndrome, obesity, type 2 diabetes mellitus, and cardiovascular disease. Therefore, there is an unmet need for novel nutritional and pharmacological strategies aimed to prevent or treat insulin resistance and its related comorbidities. This book presents a comprehensive overview of the pathophysiology and clinical consequences of insulin resistance in different settings, describing novel diagnostic biomarkers and molecular targets of this condition.

Insulin resistance. --- Metabolic syndrome.