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Cell proliferation. --- Cell differentiation. --- Cell fate specification --- Cell specification --- Cells --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Morphogenesis --- Cell renewal --- Cellular proliferation --- Cell cycle --- Cell division --- Cell populations --- Differentiation --- Fate specification --- Specification --- Growth

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More than 10 years ago, the discovery of cyclin-dependent ki­ nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg­ ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An­ other reality to emerge from the discovery of Cdks was the ex­ ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em­ braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.

Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Cell proliferation --- Cell renewal --- Cellen--Proliferatie --- Cellular proliferation --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Proliferation cellulaire --- Tumorigenesis --- Cyclin kinase --- Inhibitors --- Immunology. --- Cell biology. --- Cancer research. --- Biochemistry. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cancer research --- Cell biology --- Cellular biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Composition

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This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Life sciences. --- Cancer research. --- Cell cycle. --- Cell physiology. --- Life Sciences. --- Cell Cycle Analysis. --- Cell Physiology. --- Cancer Research. --- Cell division. --- Cell proliferation. --- Cell renewal --- Cellular proliferation --- Division of cells --- Cell function --- Cytology --- Physiology --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Cancer research --- Biosciences --- Sciences, Life --- Science --- Cell cycle --- Cell division --- Cell populations --- Cells --- Cell proliferation --- Growth --- Oncology. --- Tumors

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Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.

Receptors --- Immunosuppressive Agents. --- Lymphocyte Activation. --- Immunologic. --- Immune System Processes --- Immunity, Cellular --- Immunologic Tests --- Receptors, Cell Surface --- Immunologic Factors --- Amino Acids, Aromatic --- Adaptive Immunity --- Immune System Phenomena --- Membrane Proteins --- Physiological Effects of Drugs --- Amino Acids, Cyclic --- Immunologic Techniques --- Laboratory Techniques and Procedures --- Investigative Techniques --- Immunity --- Amino Acids --- Proteins --- Diagnosis --- Phenomena and Processes --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Chemicals and Drugs --- Immunosuppressive Agents --- Lymphocyte Activation --- Tyrosine --- Receptors, Immunologic --- Immunology. --- Cell biology. --- Cancer research. --- Cell Biology. --- Cancer Research. --- Cancer research --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Cell proliferation. --- Cell renewal --- Cellular proliferation --- Cell cycle --- Cell division --- Cell populations --- Growth

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Cell proliferation. --- Cells --- Plant cell cycle. --- Growth --- Regulation. --- Phytohistology. Phytocytology --- 576.36 --- 576.35 --- 581.17 --- Cell proliferation --- -Plant cell cycle --- Biological rhythms in plants --- Cell cycle --- Cell renewal --- Cellular proliferation --- Cell division --- Cell populations --- Life cycle of the cell --- Cell reproduction. Cell division --- Physiology of the cell --- -Regulation --- 581.17 Physiology of the cell --- 576.35 Cell reproduction. Cell division --- 576.36 Life cycle of the cell --- Plant cell cycle --- Organisms --- Cytology --- Growth&delete& --- Regulation --- Regulation of cell growth --- Biological control systems --- Cellular control mechanisms