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Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Bones --- Bone metastasis. --- Cancer. --- Bone Neoplasms. --- Cancer --- Treatment. --- Bone Neoplasms --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis

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Bones --- Tumors --- Treatment. --- Thermotherapy. --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Osteology --- Musculoskeletal system --- Bone --- Skeleton --- Bone Neoplasms. --- Microwaves --- therapeutic use. --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Ossos --- Termoteràpia

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SOFT TISSUE NEOPLASMS --- BONE NEOPLASMS --- BONE DISEASES --- JOINT DISEASES --- MICROSCOPY, ELECTRON --- Bone Diseases. --- Bone Neoplasms. --- Joint Diseases. --- Microscopy, Electron. --- Soft Tissue Neoplasms. --- Neoplasm, Soft Tissue --- Neoplasms, Soft Tissue --- Soft Tissue Neoplasm --- Neoplasms, Connective Tissue --- Electron Microscopy --- Disease, Joint --- Diseases, Joint --- Joint Disease --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Bone Disease --- Disease, Bone --- Diseases, Bone --- Arthropathies --- Arthroses --- Arthrosis --- Arthropathy --- Bone Diseases --- Bone Neoplasms --- Joint Diseases --- Microscopy, Electron --- Soft Tissue Neoplasms

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Angiography. --- Bone and Bones --- Bone Neoplasms --- Cartilage --- Neoplasms --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Medical Oncology --- Cartilages --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Bone --- Bones --- Bones and Bone --- Bones and Bone Tissue --- Bony Apophyses --- Bony Apophysis --- Condyle --- Bone Tissue --- Apophyses, Bony --- Apophysis, Bony --- Bone Tissues --- Condyles --- Tissue, Bone --- Tissues, Bone --- Skeleton --- Angiogram --- Arteriography --- Angiograms --- Angiographies --- Arteriographies --- Arteries --- Blood Vessels --- radiography. --- Angiography --- BONE AND BONES --- BONE NEOPLASMS --- CARTILAGE --- NEOPLASMS --- radiography --- Bone and bones --- Bone neoplasms --- Radiography. --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant

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Orthopedics. --- Orthopaedics --- Orthopedia --- Surgery --- Bone Neoplasms. --- Orthopedic Procedures. --- Reconstructive Surgical Procedures. --- Orthopedic Rehabilitation Surgery --- Orthopedic Surgical Procedures --- Orthopedic Surgery --- Surgery, Orthopedic --- Orthopedic Procedure --- Orthopedic Rehabilitation Surgeries --- Orthopedic Surgeries --- Orthopedic Surgical Procedure --- Procedure, Orthopedic --- Procedure, Orthopedic Surgical --- Procedures, Orthopedic --- Procedures, Orthopedic Surgical --- Rehabilitation Surgeries, Orthopedic --- Rehabilitation Surgery, Orthopedic --- Surgeries, Orthopedic --- Surgeries, Orthopedic Rehabilitation --- Surgery, Orthopedic Rehabilitation --- Surgical Procedure, Orthopedic --- Surgical Procedures, Orthopedic --- Orthopedics --- Cosmetic Reconstructive Surgery --- Procedure, Reconstructive Surgical --- Procedures, Reconstructive Surgical --- Reconstructive Surgery --- Reconstructive Surgical Procedure --- Reconstructive Surgical Procedures, Esthetic --- Surgical Procedure, Reconstructive --- Surgical Procedures, Reconstructive --- Cosmetic Reconstructive Surgical Procedures --- Reconstructive Surgical Procedures, Cosmetic --- Cosmetic Reconstructive Surgeries --- Reconstructive Surgeries --- Reconstructive Surgeries, Cosmetic --- Reconstructive Surgery, Cosmetic --- Surgeries, Cosmetic Reconstructive --- Surgeries, Reconstructive --- Surgery, Cosmetic Reconstructive --- Surgery, Reconstructive --- Surgery, Plastic --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Cosmetic Surgical Procedures --- Esthetic Reconstructive Surgical Procedures --- Esthetic Surgical Procedures --- Plastic Surgical Procedures --- Reconstructive Surgical Procedures --- Cosmetic Surgical Procedure --- Esthetic Surgical Procedure --- Plastic Surgery Procedure --- Plastic Surgical Procedure --- Procedure, Cosmetic Surgical --- Procedure, Esthetic Surgical --- Procedure, Plastic Surgery --- Procedure, Plastic Surgical --- Procedures, Cosmetic Surgical --- Procedures, Esthetic Surgical --- Procedures, Plastic Surgery --- Procedures, Plastic Surgical --- Surgery Procedure, Plastic --- Surgery Procedures, Plastic --- Surgical Procedure, Cosmetic --- Surgical Procedure, Esthetic --- Surgical Procedure, Plastic --- Surgical Procedures, Cosmetic --- Surgical Procedures, Esthetic --- Surgical Procedures, Plastic