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Proteases : potential role in health and disease : proceedings of the second international symposium, May 17-20, 1987, Rothenburg ob der Tauber
Authors: ---
ISBN: 0306430185 1461283132 1461310571 Year: 1987 Volume: vol 240 Publisher: New York London Plenum

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Viral proteases and their inhibitors
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ISBN: 0128096829 0128097124 9780128096826 9780128097120 Year: 2017 Publisher: London, United Kingdom Academic Press is an imprint of Elsevier

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Proteases of infectious agents
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ISBN: 9780124205109 0124205100 9781429497749 1429497742 0080525741 9780080525747 1281025119 9781281025111 9786611025113 Year: 1999 Publisher: San Diego, Calif. Academic

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Proteases are enzymes that essentially ""eat"" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.

Therapeutic approaches for metastasis treatment
Authors: --- ---
ISBN: 3540606807 3540606815 3540606823 3642646972 3642611079 3642646980 3642611095 3642800734 3642800718 9783540606802 Year: 1996 Volume: III Publisher: Berlin ; Heidelberg ; New York Springer

Proteases as targets for therapy
Authors: --- ---
ISBN: 3540661182 3642630235 3642570925 Year: 2000 Volume: 140 Publisher: Berlin ; Heidelberg ; New York Springer Verlag


Book
Resistance to Proteasome Inhibitors in Cancer : Molecular Mechanisms and Strategies to Overcome Resistance
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ISBN: 3319067524 3319067516 Year: 2014 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.


Book
Biology of serpins
Authors: ---
ISBN: 0123864712 9780123864710 9786613164285 1283164280 0123864720 Year: 2011 Publisher: Amsterdam : Elsevier,

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Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.


Book
Viral proteases and Antiviral protease inhibitor therapy : proteases in biology and disease
Authors: ---
ISBN: 9400726007 904812347X 9786612331138 1282331132 9048123488 Year: 2009 Publisher: Dordrecht : Springer-Verlag,

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The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Keywords

Virus inhibitors. --- Virus inhibitors --- Peptide Hydrolases --- Antiviral Agents --- Protease Inhibitors --- Viruses --- Organisms --- Anti-Infective Agents --- Hydrolases --- Enzyme Inhibitors --- Therapeutic Uses --- Enzymes --- Molecular Mechanisms of Pharmacological Action --- Pharmacologic Actions --- Enzymes and Coenzymes --- Chemical Actions and Uses --- Chemicals and Drugs --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Protease inhibitors. --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Inhibitors --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Medicinal chemistry. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Biomedicine general. --- Medicinal Chemistry. --- Infectious Diseases. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Enzyme inhibitors --- Microbiology. --- Medical virology. --- Biochemistry. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Biology --- Medical microbiology --- Virology --- Virus diseases --- Microbial biology --- Microorganisms --- Composition --- Health Workforce --- Biomedicine, general.

Membrane proteins
Authors: ---
ISBN: 0080226264 0080215270 0080226248 0080226302 0080226310 008022623X 0080226299 0080226272 0080226280 0080226256 1322260583 1483145867 132227360X 1483145883 1322336989 1483153878 1322334218 1483154068 1322334226 148316005X 1322334463 1483188353 1322336997 1483148769 1322334234 1483153894 9780080226262 Year: 1978 Volume: 45 Publisher: Oxford: Pergamon,

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Keywords

Biomembranes --- Hormone receptors --- Membrane proteins --- Energy transfer --- Energy metabolism --- Receptors, Cell Surface --- Membrane Proteins --- Energy Transfer --- Congresses --- 577.112 --- Energy Transfer. --- Membrane Proteins. --- Receptors, Cell Surface. --- -Energy transfer --- -Hormone receptors --- -Membrane proteins --- -Membranes (Biology) --- Proteins --- Hormones --- Receptors, Hormone --- Cell receptors --- Energy storage --- Force and energy --- Transport theory --- Bioenergetics --- Metabolism --- Microbial respiration --- Cell Surface Hormone Receptors --- Endogenous Substances Receptors --- Cell Surface Receptors --- Hormone Receptors, Cell Surface --- Receptors, Endogenous Substances --- Binding Sites --- Ligands --- Receptor Cross-Talk --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Cell Membrane --- Membranes --- Transfer, Energy --- Receptors --- Conferences - Meetings --- 577.218 --- Gene expression --- -Genes --- Genetic regulation --- Molecular mechanisms of control : gene expression. Molecular embryology --- Expression --- 577.152.1 --- Oxidases --- -Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.112.824 --- Albumin --- -Albumen --- Albumins --- Carbohydrate Metabolism. --- Carbohydrate metabolism --- -Metabolism --- -577.124 --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Metabolism, Carbohydrate --- Carbohydrates --- Regulation --- -Congresses --- metabolism --- 577.175.322 --- Cells --- -Growth --- -Growth regulators --- -Growth regulating substances --- Morphology (Animals) --- Developmental biology --- Organisms --- Cytology --- Growth hormone. Somatotrophic hormone --- Growth --- Fatty Acids --- 577.125 --- Glycerides --- Fatty acids --- -Glycerides --- -Acids, Fatty --- Carboxylic acids --- metabolism. --- Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Protease Inhibitors. --- Peptide Hydrolases --- 577.152.34 --- 612.321 --- Protease inhibitors --- Proteolytic enzymes --- -Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Enzyme inhibitors --- Antiproteases --- Protease Inhibitor --- Endopeptidase Inhibitors --- Peptidase Inhibitors --- Peptide Hydrolase Inhibitors --- Peptide Peptidohydrolase Inhibitors --- Protease Antagonists --- Antagonists, Protease --- Hydrolase Inhibitors, Peptide --- Inhibitor, Protease --- Inhibitors, Endopeptidase --- Inhibitors, Peptidase --- Inhibitors, Peptide Hydrolase --- Inhibitors, Peptide Peptidohydrolase --- Inhibitors, Protease --- Peptidohydrolase Inhibitors, Peptide --- Endopeptidases --- Exopeptidases --- Proteinase Inhibitory Proteins, Secretory --- Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- Inhibitors --- antagonists & inhibitors --- -Growth hormone. Somatotrophic hormone --- -metabolism. --- -Proteins --- -Molecular mechanisms of control : gene expression. Molecular embryology --- -Albumins --- -577.152.1 Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.175.322 Growth hormone. Somatotrophic hormone --- 612.321 Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- 577.152.34 Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- 577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- -577.112 Proteins --- Membranes (Biology) --- 577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- 577.124 Carbohydrate metabolism --- 612.398 --- -Proteins in human nutrition --- -Nutrition --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- 612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- 577.112 Proteins --- -612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- -577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Acids, Fatty --- -577.175.322 Growth hormone. Somatotrophic hormone --- Growth regulating substances --- -577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- Genes --- -Proteolytic enzyme inhibitors --- Peptide hydrolases --- Nutrition --- Antiprotease --- Endopeptidase Inhibitor --- Peptidase Inhibitor --- Peptide Hydrolase Inhibitor --- Peptide Peptidohydrolase Inhibitor --- Protease Antagonist --- Antagonist, Protease --- Hydrolase Inhibitor, Peptide --- Inhibitor, Endopeptidase --- Inhibitor, Peptidase --- Inhibitor, Peptide Hydrolase --- Inhibitor, Peptide Peptidohydrolase --- Peptidohydrolase Inhibitor, Peptide --- Cell Surface Receptor --- Receptor, Cell Surface --- Surface Receptor, Cell --- Cell Membrane Protein --- Cell Surface Protein --- Membrane-Associated Protein --- Surface Protein --- Membrane Associated Protein --- Membrane Protein, Cell --- Protein, Cell Membrane --- Protein, Cell Surface --- Protein, Membrane-Associated --- Protein, Surface --- Surface Protein, Cell --- Protease Inhibitors --- Carbohydrate Metabolism --- -metabolism --- Hormone receptors - Congresses --- Membrane proteins - Congresses --- Energy transfer - Congresses --- Energy metabolism - Congresses --- Receptors, Cell Surface - congresses --- Membrane Proteins - congresses --- Energy Transfer - congresses --- -Transfer, Energy

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