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Proteolytic enzymes --- Congresses --- Physiology [Pathological ] --- Proteolytic enzyme inhibitors --- Peptide hydrolases --- Protease inhibitors
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Protease inhibitors. --- Proteolytic enzymes. --- Virus inhibitors. --- Antiviruses --- Antiviral agents --- Viruses --- Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Enzyme inhibitors --- Inhibitors
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Proteases are enzymes that essentially ""eat"" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.
Microbial enzymes. --- Protease inhibitors. --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Enzyme inhibitors --- Enzymes --- Microbiological chemistry --- Inhibitors
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Metastasis. --- Neoplasm Metastasis --- Cancer metastasis --- Dissemination of cancer --- Inhibiteurs d'enzymes proteolitiques --- Metastase --- Metastases --- Metastasis --- Métastase --- Neoplasm metastasis --- Proteolytic enzyme inhibitors --- Proteolytische enzymeninhibitoren --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Cancer invasiveness --- Regulation --- Diagnosis --- Treatment
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Pathological biochemistry --- Proteolytic enzyme inhibitors --- Therapeutic use. --- Proteolitic enzyme inhibitors --- Therapeutic use --- Pharmacology. --- Biochemistry. --- Molecular biology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Composition --- Physiological effect
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Protease inhibitors --- Amyloid beta-protein precursor --- Proteolytic enzymes --- Alzheimer's disease --- Alzheimer Disease --- Endopeptidases --- Metabolism --- Pathogenesis --- etiology --- physiopathology --- Alzheimer's Disease --- Peptide Peptidohydrolases --- Protease Inhibitors --- congresses. --- Congresses --- Proteolitic enzyme inhibitors --- Alzheimer's disease - Pathogenesis - Congresses. --- Amyloid beta-protein precursor - Metabolism - Congresses. --- Proteolytic enzymes - Congresses. --- Proteolytic enzyme inhibitors - Congresses. --- Amyloid beta-protein precursor - Metabolism --- Alzheimer's disease - Pathogenesis --- Alzheimer Disease - etiology - congresses --- Endopeptidases - congresses --- Alzheimer Disease - physiopathology - congresses
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The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
Protease inhibitors --- Cancer --- Therapeutic use. --- Chemotherapy. --- Antineoplastic agents --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Enzyme inhibitors --- Treatment --- Inhibitors --- Oncology. --- Drug interactions. --- Toxicology. --- Medicine. --- Cancer Research. --- Drug Resistance. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Interactions, Drug --- Drugs --- Tumors --- Toxicology --- Side effects --- Health Workforce --- Cancer research. --- Drug resistance. --- Pharmacology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Resistance to drugs --- Cancer research --- Physiological effect
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Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.
Protein folding. --- Proteins -- Biotechnology. --- Proteins. --- Serpins. --- Biophysical Processes --- Peptides --- Biochemical Processes --- Proteins --- Mice --- Animals, Genetically Modified --- Investigative Techniques --- Proteinase Inhibitory Proteins, Secretory --- Murinae --- Animal Population Groups --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Biophysical Phenomena --- Physical Processes --- Amino Acids, Peptides, and Proteins --- Chemical Processes --- Physical Phenomena --- Animals --- Muridae --- Chemicals and Drugs --- Chemical Phenomena --- Phenomena and Processes --- Rodentia --- Eukaryota --- Organisms --- Mammals --- Vertebrates --- Chordata --- Serpins --- Mice, Transgenic --- Models, Animal --- Protein Folding --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biotechnology. --- Protease inhibitors. --- Clinical enzymology. --- Diagnostic enzymology --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Inhibitors --- Clinical chemistry --- Enzymology --- Enzyme inhibitors
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The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Virus inhibitors. --- Virus inhibitors --- Peptide Hydrolases --- Antiviral Agents --- Protease Inhibitors --- Viruses --- Organisms --- Anti-Infective Agents --- Hydrolases --- Enzyme Inhibitors --- Therapeutic Uses --- Enzymes --- Molecular Mechanisms of Pharmacological Action --- Pharmacologic Actions --- Enzymes and Coenzymes --- Chemical Actions and Uses --- Chemicals and Drugs --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Protease inhibitors. --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Inhibitors --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Medicinal chemistry. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Biomedicine general. --- Medicinal Chemistry. --- Infectious Diseases. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Enzyme inhibitors --- Microbiology. --- Medical virology. --- Biochemistry. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Biology --- Medical microbiology --- Virology --- Virus diseases --- Microbial biology --- Microorganisms --- Composition --- Health Workforce --- Biomedicine, general.
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Biomembranes --- Hormone receptors --- Membrane proteins --- Energy transfer --- Energy metabolism --- Receptors, Cell Surface --- Membrane Proteins --- Energy Transfer --- Congresses --- 577.112 --- Energy Transfer. --- Membrane Proteins. --- Receptors, Cell Surface. --- -Energy transfer --- -Hormone receptors --- -Membrane proteins --- -Membranes (Biology) --- Proteins --- Hormones --- Receptors, Hormone --- Cell receptors --- Energy storage --- Force and energy --- Transport theory --- Bioenergetics --- Metabolism --- Microbial respiration --- Cell Surface Hormone Receptors --- Endogenous Substances Receptors --- Cell Surface Receptors --- Hormone Receptors, Cell Surface --- Receptors, Endogenous Substances --- Binding Sites --- Ligands --- Receptor Cross-Talk --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Cell Membrane --- Membranes --- Transfer, Energy --- Receptors --- Conferences - Meetings --- 577.218 --- Gene expression --- -Genes --- Genetic regulation --- Molecular mechanisms of control : gene expression. Molecular embryology --- Expression --- 577.152.1 --- Oxidases --- -Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.112.824 --- Albumin --- -Albumen --- Albumins --- Carbohydrate Metabolism. --- Carbohydrate metabolism --- -Metabolism --- -577.124 --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Metabolism, Carbohydrate --- Carbohydrates --- Regulation --- -Congresses --- metabolism --- 577.175.322 --- Cells --- -Growth --- -Growth regulators --- -Growth regulating substances --- Morphology (Animals) --- Developmental biology --- Organisms --- Cytology --- Growth hormone. Somatotrophic hormone --- Growth --- Fatty Acids --- 577.125 --- Glycerides --- Fatty acids --- -Glycerides --- -Acids, Fatty --- Carboxylic acids --- metabolism. --- Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Protease Inhibitors. --- Peptide Hydrolases --- 577.152.34 --- 612.321 --- Protease inhibitors --- Proteolytic enzymes --- -Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Enzyme inhibitors --- Antiproteases --- Protease Inhibitor --- Endopeptidase Inhibitors --- Peptidase Inhibitors --- Peptide Hydrolase Inhibitors --- Peptide Peptidohydrolase Inhibitors --- Protease Antagonists --- Antagonists, Protease --- Hydrolase Inhibitors, Peptide --- Inhibitor, Protease --- Inhibitors, Endopeptidase --- Inhibitors, Peptidase --- Inhibitors, Peptide Hydrolase --- Inhibitors, Peptide Peptidohydrolase --- Inhibitors, Protease --- Peptidohydrolase Inhibitors, Peptide --- Endopeptidases --- Exopeptidases --- Proteinase Inhibitory Proteins, Secretory --- Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- Inhibitors --- antagonists & inhibitors --- -Growth hormone. Somatotrophic hormone --- -metabolism. --- -Proteins --- -Molecular mechanisms of control : gene expression. Molecular embryology --- -Albumins --- -577.152.1 Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.175.322 Growth hormone. Somatotrophic hormone --- 612.321 Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- 577.152.34 Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- 577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- -577.112 Proteins --- Membranes (Biology) --- 577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- 577.124 Carbohydrate metabolism --- 612.398 --- -Proteins in human nutrition --- -Nutrition --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- 612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- 577.112 Proteins --- -612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- -577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Acids, Fatty --- -577.175.322 Growth hormone. Somatotrophic hormone --- Growth regulating substances --- -577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- Genes --- -Proteolytic enzyme inhibitors --- Peptide hydrolases --- Nutrition --- Antiprotease --- Endopeptidase Inhibitor --- Peptidase Inhibitor --- Peptide Hydrolase Inhibitor --- Peptide Peptidohydrolase Inhibitor --- Protease Antagonist --- Antagonist, Protease --- Hydrolase Inhibitor, Peptide --- Inhibitor, Endopeptidase --- Inhibitor, Peptidase --- Inhibitor, Peptide Hydrolase --- Inhibitor, Peptide Peptidohydrolase --- Peptidohydrolase Inhibitor, Peptide --- Cell Surface Receptor --- Receptor, Cell Surface --- Surface Receptor, Cell --- Cell Membrane Protein --- Cell Surface Protein --- Membrane-Associated Protein --- Surface Protein --- Membrane Associated Protein --- Membrane Protein, Cell --- Protein, Cell Membrane --- Protein, Cell Surface --- Protein, Membrane-Associated --- Protein, Surface --- Surface Protein, Cell --- Protease Inhibitors --- Carbohydrate Metabolism --- -metabolism --- Hormone receptors - Congresses --- Membrane proteins - Congresses --- Energy transfer - Congresses --- Energy metabolism - Congresses --- Receptors, Cell Surface - congresses --- Membrane Proteins - congresses --- Energy Transfer - congresses --- -Transfer, Energy
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