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A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. There are numerous literature resources available to pharmaceutical scientists to educate and provide guidance toward formulations development with poorly water-soluble drugs; however, a single, comprehensive reference is lacking. Furthermore, without access to a vast journal library, the detailed methods used to implement these approaches are not available. The objective of this volume is therefore to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.

Drug development. --- Drugs -- Design. --- Drug development --- Drugs --- Physicochemical Phenomena --- Pharmacokinetics --- Technology, Pharmaceutical --- Pharmacology --- Chemical Processes --- Chemistry --- Investigative Techniques --- Chemical Phenomena --- Biological Science Disciplines --- Natural Science Disciplines --- Metabolic Phenomena --- Pharmacological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Phenomena and Processes --- Physiological Phenomena --- Physicochemical Processes --- Solubility --- Chemistry, Pharmaceutical --- Biological Availability --- Drug Compounding --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Design --- Solutions (Pharmacy) --- Solubility. --- Drug solubility --- Dissolution --- Medicine. --- Pharmaceutical technology. --- Biomedicine. --- Pharmaceutical Sciences/Technology. --- Dosage forms --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology

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"This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immuno-regulation agents for transplantation and the local targeting of drugs, especially poorly water soluble drugs to provide enhanced therapeutic outcomes. In addition, this title highlights areas of therapy showing the most promise for improvement in clinical outcomes via advanced formulation design."--BOOK JACKET.

Chemistry, Pharmaceutical. --- Drug Delivery Systems. --- Drugs --- Drug delivery systems. --- Pharmaceutical chemistry. --- Médicaments --- Chimie pharmaceutique --- Design. --- Conception --- Administration --- Dispositifs

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Particularly in healthcare fields, there is a growing movement away from traditional lecture style courses towards active learning and team-based activities to improve retention of concepts and build higher level thinking through the application of complex problems with a strong foundation of facts and data. Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind of provide the resources and skills needed for the successful implementation of an active learning basic pharmaceutics course. This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting. It is ideal for self-learning for the beginning pharmaceutics student, based upon the extensive utilization of figures, tables, and its overview of essential topics in pharmaceutics. Essential Pharmaceutics provides the requisite foundational knowledge for the development and implementation of case studies based upon modern drug products.

Pharmaceutical chemistry. --- Drug delivery systems. --- Biomaterials. --- Drugs --- Pharmaceutics. --- Drug Delivery. --- Structure-Based Drug Design. --- Design.