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Vaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner’s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world. This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.

Antigens. --- Immunological adjuvants. --- Vaccines -- Design -- History. --- Vaccines. --- Vaccines --- Immunological adjuvants --- Antigens --- Chemistry, Pharmaceutical --- Investigative Techniques --- Biological Factors --- Immunologic Factors --- Computational Biology --- Biology --- Biological Products --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemicals and Drugs --- Pharmacology --- Complex Mixtures --- Physiological Effects of Drugs --- Chemistry --- Natural Science Disciplines --- Pharmacologic Actions --- Disciplines and Occupations --- Chemical Actions and Uses --- Genetics --- Genomics --- Adjuvants, Immunologic --- Methods --- Drug Discovery --- Health & Biological Sciences --- Microbiology & Immunology --- History --- Design --- History. --- Adjuvants (Immunology) --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Medicine. --- Immunology. --- Pharmacology. --- Bioinformatics. --- Biomedicine. --- Vaccine. --- Pharmacology/Toxicology. --- Biologicals --- Immunity --- Immunoglobulins --- Biological response modifiers --- Toxicology. --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Poisoning --- Poisons --- Data processing --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Ensuring competency in maths skills is a fundamental part of pharmacy education as accurate pharmaceutical calculations are crucial to the safe and effective use of drugs. This text combines both the scientific calculations underpinning dosage forms with calculations relating to pharmacy practice in a single resource.

Pharmaceutical arithmetic --- Drug Dosage Calculations --- Mathematical Concepts --- Pharmaceutical Preparations --- Pharmacy --- administration & dosage --- methods

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The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

Optics. Quantum optics --- Theoretical spectroscopy. Spectroscopic techniques --- Biological techniques --- Human biochemistry --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- Biotechnology --- klinische chemie --- medische biochemie --- biologische technieken --- farmacologie --- rheologie --- biochemie --- biomedische wetenschappen --- spectroscopie --- biotechnologie --- spectrometrie

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This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Human biochemistry --- Immunology. Immunopathology --- Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- Human medicine --- vaccins --- medische biochemie --- farmacologie --- geneeskunde --- vaccinatie