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The skin is an important source of biomedical information and an access way for the delivery of drugs. Currently, hypodermic needles (in the case of a venipuncture) and transdermal patches are the most common methods for the sampling of biofluids - capillary blood or interstitial fluid (ISF) - and the delivery of drugs & vaccines. However, they are often paired with the need for trained personnel, a decreased patient compliance due to pain or limited by the barrier properties of the skin. Microneedles offer several advantages such as a reduction in pain, easy usage and efficient access to the lower skin layers. The development of microneedles and their applications are considerably slowed down by the need for human and animal models during the testing phase. These bring along a host of ethical, regulatory and logistical issues and limit the potential of microneedles. Artificial skin models are easy to fabricate, offer reproducible consistent properties and have non of the previously mentioned issues. At this point, these skin equivalents are often made for mimicking either the mechanical or fluidic mechanical interactions with microneedles but often lack controllability of their corresponding properties. In this thesis, a two-layer PDMS-based mechanical skin equivalent was reproduced and insertion tests were performed with stainless steel microneedles. The results were compared with insertions in porcine skin, a well known skin equivalent, and similar deformation behaviour and a larger insertion force was measured. Porous PDMS was developed and characterized to enhance the two-layer model for the addition of microneedle injection tests. The flow resistance was controlled via properties like pore size and hydrophilicity of the porous PDMS. A similar injection pressure profile to real skin for low flow rates was achieved for the enhanced skin model. However, the controllability of this injection pressure still needs fine tuning through the optimization of pore size uniformity and hydrophilicity variations.