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In 2013, the Hirsch Institute of Tropical Medicine (HITM) was officially inaugurated as a branch of the Department of Gastroenterology, Hepatology, and Infectious Diseases at Heinrich Heine University Düsseldorf under the direction of Professor Dieter Häussinger. The HITM serves as a place of scientific medical knowledge transfer, postgraduate medical training, and of conducting scientific projects relating to tropical medicine and infectious diseases. The publication relates the past activities of the institute, its history, and perspectives. Moreover, it permits a look behind the scenes during the construction of the institute in Africa and describes the living conditions and impressions of the staff. Dieter Häussinger, Director of the HITM and the Department of Gastroenterology, Hepatology, and Infectious Diseases and Professor of Internal Medicine at Heinrich Heine University Düsseldorf, focuses on the areas of clinical and experimental hepatology and gastroenterology, he is committed to the expansion and further development of the field of infectious diseases. He encouraged the certification of his department as a Center of Infectious Diseases, the addition of a tropical medicine and an infectious diseases outpatient clinic, the building of the Liver and Infectious Diseases Center, which houses the only treatment unit in North Rhine-Westphalia for highly infectious patients, and the founding of the Hirsch Institute of Tropical Medicine.

Tropical Medicine, Infection Medicine, Medical Faculty of Adama Science and Technology University, Asella Teaching Hospital, Etiology of Chronic Liver Disease, Chronic Liver Diseases, Ensemble pour une Solidarité Thérapeutique Hospitalière En Réseau, ESTHER-Initiative. --- chronic liver diseases. --- infectiology. --- infectious diseases. --- research in high prevalence country. --- tropical medicine. --- MEDICAL / General.

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Dieses Buch bricht mit klassischen Lehrbuchkonzepten, indem es sich auf ausgewählte Kapitel der Inneren Medizin konzentriert und die ärztliche Alltagserfahrung von Ärzten der Klinik für Gastroenterologie, Hepatologie und Infektiologie der Heinrich-Heine-Universität Düsseldorf in den Vordergrund rückt. Pathophysiologische Grundlagen und Überlegungen werden dabei nur kurz angesprochen, während das praxisorientierte Handeln auch bei der Vielzahl sehr seltener Krankheiten, die üblicherweise in Lehrbüchern keine Erwähnung finden, in den Vordergrund gerückt wird. Schwerpunkte sind dabei nicht nur die Gastroenterologie, Endoskopie und Hepatologie, sondern auch die gastroenterologische Onkologie, Infektionskrankheiten, Tropenmedizin und seltene angeborene Stoffwechselkrankheiten. Die pragmatische Behandlung dieser Krankheitsbilder ist Ausdruck des Alltags einer Klinik der Maximalversorgung.

Gastroenterology. --- Digestive organs --- Metabolism --- Hepatology. --- Infection. --- Diseases --- Diagnosis. --- Treatment. --- Disorders

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One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

Liver --- Biliary tract --- Biliary tree --- Digestive organs --- Bile --- Abdomen --- Metabolism --- Disorders.

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