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Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2–Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering --- n/a --- the Bcl-2-Beclin 1 complex

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Plants possess a rather complex and efficient immune system. During their evolutionary history, plants have developed various defense strategies in order to recognize and distinguishing between self and non-self, and face pathogens and animal pests. Accordingly, to study the plant innate immunity represents a new frontier in the plant pathology and crop protection fields. This book is structured in 6 sections. The first part introduces some basic and general aspects of the plant innate immunity and crop protection. Sections 2–5 focus on fungal and oomycete diseases (section 2), bacterial and phytoplasma diseases (section 3), virus diseases (section 4), and insect pests (section 5), with a number of case studies and plant–pathogen/pest interactions. The last section deals with plant disease detection and control. The book aims to highlight new trends in these relevant areas of plant sciences, providing a global perspective that is useful for future and innovative ideas.

Bakraee --- tomato gray mold --- Citrus sinensis --- CDPKs --- salicylic acid --- calmodulin --- glycerol-3-phosphate --- biotic stress responses --- negative regulator --- rice blast --- metabolomics --- hydroperoxide lyase --- Bromoviridae --- induced defense responses --- leaf transcriptome --- calcium signature --- “Candidatus Liberibacter” --- garden impatiens --- Chilo suppressalis --- plant defence --- plant–virus interactions --- spectral distribution of light --- Magnaporthe oryzae --- plant-virus interaction --- biological control --- ultrastructure --- pathogenicity --- disease resistance --- Potato virus Y --- symbiosis --- N-hydroxypipecolic acid --- VaHAESA --- priming --- plant–microbe interactions --- systemic and local movement --- immunity --- CaWRKY40b --- plant protection products --- hypersensitive response --- cellulose synthase --- herbivore-induced defense response --- Macrosiphum euphorbiae --- RTNLB --- ISR --- RNA silencing --- herbivore-induced plant defenses --- disease management --- sustainable crop protection --- WRKY networks --- Camellia sinensis --- RNA-Seq --- transcriptional modulation --- ETI --- pathogenesis related-protein 2 --- cell wall --- basal defense --- candidate disease resistance gene --- MTI --- grapevine --- defense-related signaling pathways --- wounding --- ethylene --- CMLs --- Prune dwarf virus --- Arabidopsis thaliana --- SAR signalling --- innate immunity --- agrochemicals --- OsGID1 --- Nilaparvata lugens --- tobacco --- tomato leaf mold --- Solanum lycopersicum --- downy mildew --- pipecolic acid --- chemical elicitors --- bismerthiazol --- pre-conditioning --- gibberellin --- “Candidatus Phytoplasma” --- dieback --- CaWRKY22 --- microbiota --- Sogatella furcifera --- PTI --- SAR --- Bacillus subtilis --- PRRs --- aphid resistance --- methyl salicylate --- regurgitant --- Myzus persicae --- Agrobacterium --- Ectropis obliqua --- Capsicum annuum --- polyphenol oxidase --- plant proteases --- plant immunity --- jasmonic acid --- calcium --- light dependent signalling --- Ralstonia solanacearum --- proteomics --- plant defense response --- Arabidopsis --- Lasiodiplodia theobromae --- azelaic acid --- citrus decline disease --- New Guinea impatiens --- replication process --- rice --- mango --- ?-3 fatty acid desaturase --- Ralstonia Solanacearum --- food security --- iTRAQ --- mitogen-activated protein kinase 4