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"Understanding Creativity: Past, Present and Future Perspectives explores the symbiotic relationship between culture and creativity, particularly exploring how resources and cultural values within a society can foster or hinder creativity. Next, this compilation proposes a new method for measuring product creativity with verification of its metric characteristics. This approach entails the construction of a creativity coefficient and a uniqueness coefficient, which are based on the assessment of the originality of the answers provided by respondents. The connection between objective indicators of creativity and its representation on the level of self-consciousness is also discussed by way of a new questionnaire for implicit theories of creativity that diagnoses four scales: originality, intelligence and personal potential, novelty and activity. The authors propose and demonstrate how a student must perceive that the ability to self-correct any discrepancies between actual and desired performance is possible and achievable in order to exhibit a positive response to feedback. "Zones of in-between" are defined as organizational, social and physical spaces at school that have the potential to allow for something else than their ostensible purposes in teaching and teacher-pupil relations. Different types of presence, interactions and expressions occur when pupils have a pause from teaching and interact with other pupils. This kind of creativity is formed by and takes place in sociocultural margins and peripheries. The final paper is a qualitative narrative examination of undergraduate students' experiences in a fully online learning community, describing how a community of 90 students divided into three sections of 30 participated in a blended course for 12 weeks which used flipped classroom video podcasts, online discussion boards, and weekly synchronous Adobe Connect conferencing"--

Creative ability. --- Creativeness --- Creativity --- Ability --- Creation (Literary, artistic, etc.)

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Sociology of education --- Teaching

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Leadership.

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This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.

Antibiotics. --- Bacteriology. --- Drug interactions. --- Pharmacotherapy. --- Drug Resistance. --- Interactions, Drug --- Drugs --- Microbiology --- Side effects --- Drug resistance. --- Resistance to drugs --- Pharmacology --- Drug therapy --- Pharmacotherapy --- Therapeutics