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This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.

Cancer. --- Carcinogenesis. --- Tumors. --- Biology.

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Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment. Animal models are particularly useful for evaluating therapeutic or chemopreventive agents and examples are presented. Finally, natural products that ether prevent or treat cancer are described. Together these topics will provide the reader with examples of the latest cutting edge research and discoveries, with the goal of stimulating further advances.

Carcinogenesis. --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Pathogenesis --- Oncology

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The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Behavior genetics. --- Epigenesis, Genetic. --- Epigenetics. --- Medicine. --- Carcinogenesis --- Epigenetics --- Biology --- Neoplastic Processes --- Diseases --- Gene Expression Regulation --- Pathologic Processes --- Biological Science Disciplines --- Genetic Processes --- Natural Science Disciplines --- Genetic Phenomena --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Phenomena and Processes --- Neoplasms --- Epigenesis, Genetic --- Genetics --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Oncology --- Medical Research --- Molecular aspects --- Carcinogenesis. --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Cancer research. --- Human genetics. --- Oncology. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Tumors --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Genetic toxicology --- Oncology  . --- Molecular aspects. --- genetics --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- Molecular carcinogenesis --- Pathology, Molecular

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This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.

Carcinogenesis. --- Cell transformation, Neoplastic. --- Herpesvirus 4, Human. --- Epstein-Barr virus diseases --- Biology --- Antigens, Nuclear --- Lymphocryptovirus --- Antigens --- Gammaherpesvirinae --- Biological Science Disciplines --- Biological Factors --- Natural Science Disciplines --- Herpesviridae --- DNA Viruses --- Chemicals and Drugs --- Disciplines and Occupations --- Viruses --- Organisms --- Epstein-Barr Virus Nuclear Antigens --- Herpesvirus 4, Human --- Genetics --- Medicine --- Health & Biological Sciences --- Oncology --- Epstein-Barr virus diseases. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- EBV diseases --- Medicine. --- Cancer research. --- Medical microbiology. --- Virology. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- Tumors --- Herpesvirus diseases --- Chronic fatigue syndrome --- Oncology. --- Medical virology. --- Microbiology. --- Microbial biology --- Microorganisms --- Medical microbiology --- Virology --- Virus diseases --- Microbiology --- Cancer research

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This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies. Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy. Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.

Cancer -- Immunotherapy. --- Cellular therapy. --- Immunity, Cellular. --- Neoplasms -- Therapy. --- Epidemiologic Study Characteristics as Topic --- Diseases --- Immunomodulation --- Evaluation Studies as Topic --- Investigative Techniques --- Epidemiologic Methods --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biological Therapy --- Health Care Evaluation Mechanisms --- Public Health --- Quality of Health Care --- Therapeutics --- Environment and Public Health --- Health Care Quality, Access, and Evaluation --- Health Care --- Clinical Trials as Topic --- Neoplasms --- Immunotherapy --- Methods --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Immunotherapy. --- Immunological aspects. --- Therapeutic immunology --- Carcinogenesis --- Immunological aspects --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Clinical immunology