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2012 (23)

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Book
Bacterial glycomics : current research, technology, and applications
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ISBN: 9781904455950 1904455956 Year: 2012 Publisher: Norfolk: Caister Academic Press,

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Book
The belly fat cure sugar & carb counter : discover which foods will melt up to 9 lbs. this week
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ISBN: 1401940811 Year: 2012 Publisher: [Place of publication not identified] Hay House

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Based on the revolutionary #1 New York Times bestseller that is changing the way America eats, this is the only supermarket guide that exposes the true cause of belly fat and disease: hidden sugar!. Transforming your health, energy, and waistline is as easy as 1, 2, 3: Unlock the secret to fat loss that food conglomerates don't want you to know.; Follow the one simple menu that tells you exactly what to eat to melt up to 9 pounds this week.; Discover thousands of "Belly Good" items that make shedding pounds each week a snap. With a bonus dining-out section featuring menu items from some of your favorite restaurants, this comprehensive guide will help you look and feel your best in no time at all!.


Book
Transforming glycoscience : a roadmap for the future
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ISBN: 0309264197 0309260833 0309260841 0309260868 Year: 2012 Publisher: Washington, District of Columbia : National Academies Press,

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"A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans--also known as carbohydrates, saccharides, or simply as sugars--play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields."Publisher's description.


Book
Obesity and type 2 diabetes mellitus
Authors: ---
ISBN: 0199749760 9780199749768 1306168597 9781306168595 9780199740215 0199740216 Year: 2012 Publisher: Oxford ; New York : Oxford University Press,

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As part of the Oxford American Endocrinology Library series, this handbook reviews the epidemiology and pathophysiology of obesity and type 2 diabetes mellitus. Because of its concise yet comprehensive nature, this volume is an excellent point-of-care reference for clinicians who regularly treats obese and diabetic patients.


Book
The European polysaccharide network of excellence (EPNOE) : research initiatives and results
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ISBN: 3709104203 3709104211 1283935600 Year: 2012 Publisher: New York : Springer,

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This book provides an essential overview of the science of polysaccharides. It both approaches polysaccharides as a polymer class and provides detailed descriptions of most major polysaccharides (cellulose, mannan, xylan, chitin-chitosan, cyclodextrines). Owing to the multidisciplinary character of the European Polysaccharide Network of Excellence (EPNOE), the book describes all main aspects of polysaccharide science and technology (biology, enzymology, physics, chemistry, materials science and processing). Notations and concepts follow a uniform format throughout the whole work in order to create a valuable reference book on the field of polysaccharide science. Owing to the major importance of industry in the EPNOE, concrete applications are also described in detail.


Book
Metabolic syndrome : from risk factors to management
Authors: ---
ISBN: 8897419208 9788897419204 8897419194 9788897419198 9788897419198 9788897419204 Year: 2012 Publisher: Torino : SEEd,

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Increased caloric intake, increased refined carbohydrate consumption, and physical inactivity have led to an explosion in the worldwide incidence of abdominal obesity and the emerging epidemic of insulin resistance, resulting in an increase of metabolic syndrome. Physicians can use the metabolic syndrome concept to guide focused lifestyle changes, lower blood pressure goals, and earlier intervention with aspirin, LDL-lowering drugs, and perhaps insulin-sensitizing medications. The comprehensive "ABCDE" approach presented in this book provides a memory tool for use in everyday clinical practice


Book
From sugar to Splenda : a personal and scientific journey of a carbohydrate chemist and expert witness
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ISBN: 3642227805 3642433278 9786613573964 3642227813 1280396040 Year: 2012 Publisher: New York : Springer,

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More than just coincidence connects a Tate & Lyle lawsuit and artificial sweetener to Jamaican-born Chemist Bert Fraser-Reid. From his first experience of Chemistry through his diabetic father, to his determination and drive as a Chemistry student in Canada, Fraser-Reid weaves a remarkable tale integrating science, law and autobiographical anecdotes. This book arises from the lawsuit brought by Tate & Lyle against companies accused of infringing its patents for sucralose, the sweet ingredient in the artificial sweetener SPLENDA which is made by chlorinating sugar. From a 1958 undergraduate intern witnessing the pioneering experiments on sugar chlorination, to being the 1991 recipient of the world’s premiere prize for carbohydrate chemistry, Fraser-Reid was groomed for his role as expert witness in the mentioned lawsuit. Nevertheless, it seems more than his career links Fraser-Reid to the case.


Book
Biotechnology for pulp and paper processing
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ISBN: 1461414083 9786613443724 1461414091 1283443724 Year: 2012 Publisher: New York : Springer Science+Business Media, LLC,

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This book provides the most up-to-date information available on various biotechnological processes useful in the pulp and paper industry. Each of the twenty chapters covers a specific biotechnological process or technique, discussing the advantages, limitations, and future prospects of the most important and popular processes used in the industry. Topics covered include tree improvement, pulping, bleaching, deinking, fiber modification, biosolids management, and biorefining.


Book
Managing diabetes
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ISBN: 1908517573 1908517816 Year: 2012 Publisher: London : Springer Healthcare,

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Managing Diabetes is a up-to-date, comprehensive showcase of the current pharmaceutical trends in treating diabetes and provides a unbiased, inclusive discussion of current and emerging treatments by well-known experts in the field.


Book
Application of peptide-based prodrug chemistry in drug development
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ISBN: 1461448743 9786613937094 1461448751 1283624648 Year: 2012 Publisher: New York : Springer,

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Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it’s short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as “specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule” (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs.  Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of useful to chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010).

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