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Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodelling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Cytology. --- Medicine. --- Oncology. --- Tumors -- Blood-vessels. --- Tumors --- Angiogenesis Modulating Agents --- Antineoplastic Agents --- Diseases --- Growth Inhibitors --- Blood Circulation --- Metaplasia --- Therapeutic Uses --- Growth Substances --- Pathologic Processes --- Cardiovascular Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Physiological Effects of Drugs --- Cardiovascular Physiological Phenomena --- Pharmacologic Actions --- Circulatory and Respiratory Physiological Phenomena --- Chemical Actions and Uses --- Phenomena and Processes --- Chemicals and Drugs --- Neoplasms --- Microcirculation --- Angiogenesis Inhibitors --- Neovascularization, Pathologic --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Microcirculation. --- Tumors. --- Tumours --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pathology --- Cysts (Pathology) --- Blood --- Circulation --- Oncology  . --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research