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Acute kidney injury (AKI) is a frequent and serious complication for hospitalized patients. In spite of considerable improvement in treatments, the morbidity and mortality associated with acute kidney injury remains relatively high. The major reason being that, at the moment, we don’t know of any sensitive and specific markers of the renal function which would allow for an early diagnosis of acute kidney injury. At present, traditional biomarkers of the renal function (creatinine and urea) do not detect kidney injury early enough. In renal transplantation, the identification of adequate biomarkers of the renal function are indispensable to evaluate the quality of the transplant before the transplantation but also to minimize the risk of acute rejection and acute tubular necrosis during the post-operative period. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is an early biomarkers of acute kidney injury. This marker of tubular necrosis has been measured in the urine and in the blood of 54 patients before and at different time after a renal transplantation. Other biomarkers of the renal function (Cystatine C and β2-Microglobuline) have also been tested. The aim of the study is on the one hand to test the various biomarkers of “donor” patients according to their category (living or cadaveric donors’kidneys) and on the other hand to study these biomarkers for the “recipient” patients according to the events that occurred during the post-operative period. The preliminary results show that 13 patients developed an acute tubular necrosis (ATN) within the first 24 hours post-operation. The statistical tests show that the rates of urinary and blood NGAL were significantly higher for the patient’s who developed an ATN compared with those who didn’t. Furthermore, this difference between both groups is observed within 6 hours after the transplantation. L’atteinte rénale aiguë est une complication fréquente et sérieuse chez les patients hospitalisés. Malgré une amélioration considérable en matière de traitements, la morbidité et la mortalité associées à une atteinte rénale restent relativement élevées. La raison majeure vient du fait qu’on ne dispose pas, à l’heure actuelle, de marqueurs sensibles et spécifiques de la fonction rénale qui permettraient un diagnostic précoce de l’atteinte rénale aiguë. Actuellement les marqueurs principaux de la fonction rénale sont la créatinine et l’urée. Malheureusement ceux-ci ne détectent que tardivement des lésions rénales aiguës. Dans le domaine de la transplantation rénale, l’identification de biomarqueurs adéquats de la fonction rénale est devenue indispensable afin d’évaluer la qualité du greffon avant la transplantation mais également afin de minimiser le risque de rejet et de nécrose tubulaire aigu pendant la période postopératoire. La Neutrophil Gelatinase-Associated Lipocalin (NGAL) est un marqueur précoce d’atteinte rénale aiguè. Ce marqueur de nécrose tubulaire a été dosé dans l’urine et dans le sang de 54 patients avant et à différents temps après une transplantation rénale. D’autres marqueurs alternatifs de la fonction rénale ont également été testés comme la cystatine C et la f32 Microglobuline. L’objectif de l’étude est d’une part de tester les différents biomarqueurs chez les patients «donneurs» en fonction de leur catégorie (donneurs vivants ou donneurs cadavériques) et d’autre part d’étudier ces biomarqueurs chez les patients «receveurs» en fonction des événements survenus durant la période postopératoire. Les résultats préliminaires montrent que 13 patients ont développé une nécrose tubulaire aigu (ATN) endéans les 24H postopératoires. Les tests statistiques ont démontré que les taux de NGAL urinaire et sanguin étaient significativement plus élevés chez les patients ayant développé une ATN comparés aux patients qui n’ont pas fait d’ATN. De plus, cette différence entre les deux groupes s’observe endéans les 6H post-transplantation
Acute Kidney Injury --- Kidney Tubular Necrosis, Acute --- Biological Markers
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First aid in illness and injury --- Medical emergencies --- Traumatology
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Rats --- Lung injury --- Anti-inflammatory agents --- Cadmium --- Cholinergic antagonists --- chemically induced --- pharmacology --- toxicity
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Covers critical illness and injury science.
Critical Illness --- Critical Care --- Wounds and Injuries --- Injuries and Wounds --- Injuries, Wounds --- Research-Related Injuries --- Wounds --- Wounds and Injury --- Wounds, Injury --- Injuries --- Trauma --- Injuries, Research-Related --- Injury --- Injury and Wounds --- Injury, Research-Related --- Research Related Injuries --- Research-Related Injury --- Traumas --- Wound --- First Aid --- Traumatology --- Surgical Intensive Care --- Intensive Care --- Intensive Care, Surgical --- Care, Critical --- Care, Intensive --- Care, Surgical Intensive --- Emergencies --- Critically Ill --- Critical Illnesses --- Illness, Critical --- Illnesses, Critical --- Critical Illness. --- Critical Care. --- Wounds and Injuries. --- Critical care medicine --- Wounds and injuries --- Human beings --- Trauma, Physical --- Surgical emergencies
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pesticides --- Environmental impact --- best practices --- health protection --- Plant protection --- Disease control --- pest control --- environmental protection --- decision support --- Economic injury levels
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Chronic diseases --- Wounds and injuries --- Maladies chroniques --- Lésions et blessures --- Chronic diseases. --- Wounds and injuries. --- Canada. --- Human beings --- Injuries --- Trauma, Physical --- Wounds --- Diseases, Chronic --- NCDs (Noncommunicable diseases) --- Non-communicable diseases --- Non-infectious diseases --- Noncommunicable diseases --- Canada --- Canadae --- Ceanada --- Chanada --- Chanadey --- Dominio del Canadá --- Dominion of Canada --- Kʻaenada --- Kanada --- Ḳanadah --- Kanadaja --- Kanadas --- Ḳanade --- Kanado --- Kanakā --- Province of Canada --- Republica de Canadá --- Yn Chanadey --- Surgical emergencies --- Traumatology --- Diseases --- Kanak --- Ontario --- Québec --- Canada (Province) --- Dominio del Canad --- Republica de Canad --- Chronic Disease. --- Wounds and Injuries. --- Injuries and Wounds --- Injuries, Wounds --- Research-Related Injuries --- Wounds and Injury --- Wounds, Injury --- Trauma --- Injuries, Research-Related --- Injury --- Injury and Wounds --- Injury, Research-Related --- Research Related Injuries --- Research-Related Injury --- Traumas --- Wound --- First Aid --- Chronically Ill --- Chronic Illness --- Chronic Diseases --- Chronic Illnesses --- Disease, Chronic --- Illness, Chronic --- Illnesses, Chronic --- Pain Management --- Jianada --- Kaineḍā
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First aid in illness and injury --- Psychiatric emergencies --- Psychic trauma --- Premiers soins --- Urgences en psychiatrie --- Traumatisme psychique --- Handbooks, manuals, etc. --- Guides, manuels, etc.
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Lips --- Facial bones --- Mouth --- Surgery, Oral. --- Craniofacial Abnormalities --- Facial Bones --- Maxillofacial Injuries. --- Surgery --- surgery. --- Surgery. --- Dental surgery --- Oral surgery --- Surgery, Dental --- Surgery, Oral --- Injuries, Maxillofacial --- Injury, Maxillofacial --- Maxillofacial Injury --- Maxillofacial Surgery --- Oral Surgery --- Exodontics --- Surgery, Maxillofacial --- Facial skeleton --- Ossa faciei --- Viscerocranium --- Oral surgeons --- Oral Surgical Procedures --- Dentistry --- Face --- Head --- Skull
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Spine --- Spinal Diseases. --- Spinal Injuries. --- Diseases --- Treatment --- Abnormalities --- Surgery --- Abnormalities. --- Diseases. --- Treatment. --- Surgery. --- spinal disorders --- orthopaedic surgery --- neurosurgery --- Posture disorders --- Injuries, Spinal --- Injury, Spinal --- Spinal Injury --- Back Injuries --- Disease, Spinal --- Diseases, Spinal --- Spinal Disease --- Backbone --- Columna vertebralis --- Spinal column --- Vertebral column --- Back --- Bones --- Skeleton --- Abnormities and deformities --- injuries --- Spinal Diseases --- Spinal Injuries --- Pathology of the organs of movement
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