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Colorectal cancer, with one million new cases and half a million of deaths each year, is the third most common cancer in men and the second among women. This cancer represents an important public health problem. The prognosis and survival rate are directly related to the tumor development stage at the time of diagnosis. That’s why early detection is especially important. This cancer is among the diseases that may benefit from early detection. Indeed, this cancer has preclinical detectable lesions and is curable if detected early. Available screening methods can be classified into two groups: tests that primarily detect and tests for both cancer detection and anatomical structure determination. The screening method currently used is the detection of blood in the stool. However, the sensitivity is relatively low and needlessly submits too many patients to colonoscopy. Therefore, many studies aim to develop more efficient and non invasive tests able to detect tumor markers in blood or stool. Several genes significantly involved in the genesis of colorectal cancer have been identified. Therefore, studies have sought to identify’ the relevance of detecting them in blood or stool for colorectal cancer screening. The genes involved are Kras, p53 and APC. Studies were also conducted on the value of serological markers such as CEA, CA 19-9 and TIMP- 1 for early detection. The method of screening and anatomical structure examination is currently colonoscopy which is an invasive modality. High hopes are thus placed in the future development of non invasive methods such as virtual colonoscopy and video capsule, not validated at this time Le cancer colorectal, avec un million de nouveaux cas et un demi-million de morts chaque année, est le troisième cancer le plus fréquent chez l’homme et le deuxième plus fréquent chez la femme. Ce cancer constitue un véritable problème de santé publique. Cependant le pronostic de survie est en relation directe avec le stade de développement au moment du diagnostic. C’est pourquoi un dépistage précoce est particulièrement important. Ce cancer fait partie des maladies pouvant bénéficier d’un dépistage précoce. En effet, il est fréquent, grave, présente des lésions précliniques décelables et est guérissable s’il est détecté suffisamment tôt. Les méthodes de dépistage disponibles peuvent être classées en deux groupes: les tests permettant principalement la détection et les tests permettant à la fois la détection du cancer et un examen des structures anatomiques. La méthode de dépistage actuellement retenue est la détection du sang dans les selles. Cependant la sensibilité est relativement faible et soumet, inutilement, trop de patients à la colonoscopie. C’est pourquoi de nombreuses études visent à développer des tests plus performants et non invasifs permettant de détecter des marqueurs tumoraux dans le sang ou les selles. Plusieurs gènes significativement impliqués dans la genèse du cancer colorectal ont pu être mis en évidence. Des études cherchent donc à évaluer la pertinence que pourrait avoir la détection de ceux-ci, dans le sang ou les selles, pour le dépistage précoce du cancer colorectal. Les gènes concernés sont Kras, p53 et APC. Des études ont également été menées sur l’intérêt de marqueurs sérologiques tels que CEA, CA 19-9 et TIMP-1 pour le dépistage précoce. La méthode actuellement retenue de dépistage et d’examen des structures anatomiques est la colonoscopie qui est une modalité invasive. De bons espoirs sont placés dans le futur développement de méthodes non invasives telles que la colonoscopie virtuelle et la vidéo capsule, non encore validées

Colonoscopy --- Colonography, Computed Tomographic --- Colorectal Neoplasms

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Colonoscopy --- Three-dimensional imaging in medicine --- Colon (Anatomy) --- Cancer --- Prevention.

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This book constitutes the thoroughly refereed post-conference proceedings of the International Workshop on Computational Challenges and Clinical Opportunities in Virtual Colonoscopy and Abdominal Imaging, held in conjunction with MICCAI 2010, in Beijing, China, on September 20, 2010. The 19 revised full papers presented were carefully reviewed and selected from 26 submissions. The papers are organized in topical sections on CT colonography CAD, abdominal imaging, and virtual colonoscopy.

Colon (Anatomy) --- Radiography --- Diagnostic Techniques, Digestive System --- Publication Formats --- Tomography, X-Ray Computed --- Radiographic Image Enhancement --- Tomography, X-Ray --- Diagnostic Techniques and Procedures --- Image Interpretation, Computer-Assisted --- Publication Characteristics --- Diagnostic Imaging --- Diagnosis --- Image Enhancement --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Photography --- Colonography, Computed Tomographic --- Congresses --- Radiography, Abdominal --- Engineering & Applied Sciences --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Applied Physics --- Tomography --- Radiographic Tomography --- Tomography, Radiographic --- Tomography, X Ray --- Tomography, Xray --- Transmission Tomography --- X Ray Tomography --- Xray Tomography --- Tomography, Transmission --- X-Ray Tomography --- Zonography --- Image Enhancement, Radiographic --- Radiography, Digital --- Digital Radiography --- Enhancement, Radiographic Image --- Enhancements, Radiographic Image --- Image Enhancements, Radiographic --- Radiographic Image Enhancements --- CAT Scan, X Ray --- CT X Ray --- Computed Tomography, X-Ray --- Computed X Ray Tomography --- Computerized Tomography, X Ray --- Electron Beam Tomography --- Tomography, X Ray Computed --- Tomography, X-Ray Computer Assisted --- Tomography, X-Ray Computerized --- Tomography, X-Ray Computerized Axial --- Tomography, Xray Computed --- X Ray Computerized Tomography --- X Ray Tomography, Computed --- X-Ray Computer Assisted Tomography --- X-Ray Computerized Axial Tomography --- CAT Scan, X-Ray --- CT Scan, X-Ray --- Cine-CT --- Computerized Tomography, X-Ray --- Electron Beam Computed Tomography --- Tomodensitometry --- Tomography, Transmission Computed --- X-Ray Tomography, Computed --- Beam Tomography, Electron --- CAT Scans, X-Ray --- CT Scan, X Ray --- CT Scans, X-Ray --- CT X Rays --- Cine CT --- Computed Tomography, Transmission --- Computed Tomography, X Ray --- Computed Tomography, Xray --- Computed X-Ray Tomography --- Scan, X-Ray CAT --- Scan, X-Ray CT --- Scans, X-Ray CAT --- Scans, X-Ray CT --- Tomographies, Computed X-Ray --- Tomography, Computed X-Ray --- Tomography, Electron Beam --- Tomography, X Ray Computer Assisted --- Tomography, X Ray Computerized --- Tomography, X Ray Computerized Axial --- Transmission Computed Tomography --- X Ray Computer Assisted Tomography --- X Ray Computerized Axial Tomography --- X Ray, CT --- X Rays, CT --- X-Ray CAT Scan --- X-Ray CAT Scans --- X-Ray CT Scan --- X-Ray CT Scans --- X-Ray Computed Tomography --- X-Ray Computerized Tomography --- Xray Computed Tomography --- Diagnostic Technic, Digestive System --- Diagnostic Technics, Digestive System --- Diagnostic Technique, Digestive System --- Digestive System Diagnostic Technic --- Digestive System Diagnostic Technics --- Digestive System Diagnostic Technique --- Digestive System Diagnostic Techniques --- Technic, Digestive System Diagnostic --- Technics, Digestive System Diagnostic --- Technique, Digestive System Diagnostic --- Techniques, Digestive System Diagnostic --- Abdominal Radiography --- Abdominal Radiographies --- Radiographies, Abdominal --- CT Colonography --- Colonoscopy, Virtual --- Computed Tomographic Colonography --- Virtual Colonoscopy --- Colonography, CT --- Photographies --- Image Quality Enhancement --- Enhancement, Image --- Enhancement, Image Quality --- Enhancements, Image --- Enhancements, Image Quality --- Image Enhancements --- Image Quality Enhancements --- Quality Enhancement, Image --- Quality Enhancements, Image --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Imaging, Diagnostic --- Imaging, Medical --- Medical Imaging --- Image Interpretation, Computer Assisted --- Computer-Assisted Image Interpretation --- Computer-Assisted Image Interpretations --- Image Interpretations, Computer-Assisted --- Interpretation, Computer-Assisted Image --- Interpretations, Computer-Assisted Image --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnostic X-Ray --- Diagnostic X-Ray Radiology --- X-Ray Radiology, Diagnostic --- Radiology, Diagnostic X-Ray --- Roentgenography --- X-Ray, Diagnostic --- Diagnostic X Ray --- Diagnostic X Ray Radiology --- Diagnostic X-Rays --- Radiology, Diagnostic X Ray --- X Ray Radiology, Diagnostic --- X Ray, Diagnostic --- X-Rays, Diagnostic --- Computed tomographic colonography --- Tomographic colonography --- Virtual colonoscopy --- diagnosis --- methods --- Computer science. --- Radiology. --- User interfaces (Computer systems). --- Computer graphics. --- Image processing. --- Pattern recognition. --- Computer Science. --- Image Processing and Computer Vision. --- Pattern Recognition. --- User Interfaces and Human Computer Interaction. --- Computer Graphics. --- Computer Imaging, Vision, Pattern Recognition and Graphics. --- Imaging / Radiology. --- Design perception --- Pattern recognition --- Form perception --- Perception --- Figure-ground perception --- Pictorial data processing --- Picture processing --- Processing, Image --- Imaging systems --- Optical data processing --- Automatic drafting --- Graphic data processing --- Graphics, Computer --- Computer art --- Graphic arts --- Electronic data processing --- Engineering graphics --- Image processing --- Interfaces, User (Computer systems) --- Human-machine systems --- Human-computer interaction --- Radiological physics --- Physics --- Radiation --- Informatics --- Science --- Digital techniques --- Computer vision. --- Optical pattern recognition. --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Pattern perception --- Perceptrons --- Visual discrimination --- Machine vision --- Vision, Computer --- Artificial intelligence --- Pattern recognition systems --- Colonography, Computed Tomographic. --- Radiography, Abdominal. --- Tomography. --- Optical data processing. --- Optical computing --- Visual data processing --- Bionics --- Integrated optics --- Photonics --- Computers --- Optical equipment