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This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.

Cancer -- Treatment. --- Protein drugs. --- Protein engineering. --- Recombinant proteins -- Therapeutic use. --- Amino Acids, Peptides, and Proteins --- Ubiquitins --- Diseases --- Enzyme Inhibitors --- Molecular Mechanisms of Pharmacological Action --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Neoplasms --- Protease Inhibitors --- Ubiquitin --- Proteins --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Cancer --- Treatment. --- Protein pharmaceuticals --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Human genetics. --- Immunology. --- Medical microbiology. --- Biochemistry. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- Human Genetics. --- Biochemistry, general. --- Drugs --- Oncology. --- Microbiology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Microbial biology --- Microorganisms --- Tumors --- Composition --- Cancer research