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Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.

Cancer. --- Neoplasms. --- Oncology. --- Neoplasms --- Drug Delivery Systems --- Antineoplastic Agents --- Drug Therapy --- Therapeutic Uses --- Diseases --- Pharmacologic Actions --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Chemicals and Drugs --- Biomedical Engineering --- Oncology --- Medicine --- Health & Biological Sciences --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Medicine. --- Medicine & Public Health. --- Tumors --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Oncology  .

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Pharmaceutical Perspectives of Cancer Therapeutics presents a comprehensive yet easy-to-follow review of the principles, current progress and state-of-the-art of cancer therapeutics. The complexity of cancer demands an integrated understanding from both cancer biology and pharmaceutical dosage forms and drug delivery in order to warrant a successful therapeutic regimen. This book combines and merges the knowledge from these two aspects. Internationally acclaimed experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries have contributed to this book to bridge the following areas between basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance. Main features of the book: Anticancer drug development and regulatory processes. Strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways. Therapeutic approaches to employ monoclonal antibody and cancer vaccines. Introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling. Use of lipids, polymers and peptides for drug delivery and targeting to cancer cells or specific organs. Utilization of bioimaging and HIF-1 knockout animal models in cancer study. Clinical trials designs and principles.

Antineoplastic agents. --- Cancer --Chemotherapy. --- Cancer --- Antineoplastic agents --- Chemistry, Pharmaceutical --- Diseases --- Drug Therapy --- Therapeutic Uses --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Therapeutics --- Pharmacology --- Chemistry --- Chemical Actions and Uses --- Biological Science Disciplines --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Antineoplastic Agents --- Drug Discovery --- Drug Delivery Systems --- Neoplasms --- Health & Biological Sciences --- Medicine --- Oncology --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Development. --- Chemotherapy. --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Treatment --- Oncology. --- Tumors --- Cancer research

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Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Dopaminergic neurons. --- Dopaminergic neurons --- Neurotransmitter Agents --- Neurons --- Dopamine --- Physiology --- Catecholamines --- Biological Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Physiological Effects of Drugs --- Cells --- Nervous System --- Biogenic Monoamines --- Pharmacologic Actions --- Anatomy --- Natural Science Disciplines --- Amines --- Biogenic Amines --- Chemical Actions and Uses --- Disciplines and Occupations --- Organic Chemicals --- Chemicals and Drugs --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Dopamine neurons --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Dopaminergic mechanisms --- Health Workforce --- Biomedicine, general.

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Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Cancer cells --- Chemokines --- Receptors, Cytokine --- Antigens, CD --- Receptors, G-Protein-Coupled --- Diseases --- Angiogenesis Modulating Agents --- Growth Substances --- Receptors, Immunologic --- Antigens, Differentiation --- Receptors, Cell Surface --- Membrane Proteins --- Biological Markers --- Antigens, Surface --- Physiological Effects of Drugs --- Pharmacologic Actions --- Proteins --- Antigens --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Angiogenesis Inducing Agents --- Neoplasms --- Receptors, Chemokine --- Biology --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Oncology --- Microbiology & Immunology --- Growth --- Regulation. --- Receptors --- Effect of drugs on. --- Effect of drugs on --- Regulation --- Chemokines. --- Drug receptors. --- Drugs --- Receptors, Drug --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Cell receptors --- Cytokines --- Inflammation --- Peptides --- Mediators --- Oncology  . --- Tumors --- Cancer research

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Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable. "The adjuvant treatment of breast cancer has become standard of care. A spectrum of biologic and prognostic factors are considered before a therapeutic strategy is implemented. In this text leading investigators in the field discuss current management and critical investigative issues." Steven T. Rosen, M.D. Series Editor.

Breast -- Cancer -- Adjuvant treatment. --- Breast -- Cancer -- Treatment. --- Breast -- Cancer. --- Cancer. --- Breast --- Breast Diseases --- Combined Modality Therapy --- Radiotherapy --- Neoplasms by Site --- Pharmaceutic Aids --- Drug Therapy --- Therapeutics --- Neoplasms --- Skin Diseases --- Specialty Uses of Chemicals --- Pharmaceutical Preparations --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Skin and Connective Tissue Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Adjuvants, Pharmaceutic --- Chemotherapy, Adjuvant --- Radiotherapy, Adjuvant --- Breast Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Adjuvant treatment --- Cancer --- Adjuvant treatment. --- Treatment. --- Medicine. --- Cancer research. --- Oncology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Cancer Research. --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excision --- Treatment