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Over the last decades, the growing prevalence of insulin resistance has dramatically contributed to the global epidemic of metabolic syndrome, obesity, type 2 diabetes mellitus, and cardiovascular disease. Therefore, there is an unmet need for novel nutritional and pharmacological strategies aimed to prevent or treat insulin resistance and its related comorbidities. This book presents a comprehensive overview of the pathophysiology and clinical consequences of insulin resistance in different settings, describing novel diagnostic biomarkers and molecular targets of this condition.

Insulin resistance. --- Metabolic syndrome.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Insulin --- Metabolic syndrome (MetS) --- Cognition --- Metabolism --- Brain

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

apoptosis --- insulin-like factors --- neurodegeneration --- senescence --- sex hormones

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The purpose of these books is to have an updated systematic overview examining, in detail, the functional role of different diets and dietary components in maintaining glucose homeostasis and preventing long-term complications. The first book includes experimental evidence from preclinical research, whereas the second book provides studies in the clinical scenario.

Metabolic syndrome --- Diet therapy. --- Cardiovascular syndrome, Metabolic --- Dysmetabolic syndrome X --- Insulin resistance syndrome --- Metabolic cardiovascular syndrome --- Metabolic syndrome X --- Insulin resistance --- Metabolism --- Syndromes --- Disorders

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The aim of this Special Issue focusing on "Nutritional Intake and the Risk of Non-Alcoholic Fatty Liver Disease" is to provide an in-depth overview of the role of the intake of different macro- and micronutrients in the development and progression of non-alcoholic fatty liver disease, as well as in its prevention and treatment. General over-nutrition but also alterations of the dietary pattern (e.g., towards a higher intake of fat, cholesterol, and sugar-and herein especially fructose) are discussed as being critical in the development of non-alcoholic fatty liver disease (NAFLD). However, it has also been suggested that a general reduction of caloric intake and/or modulation of dietary composition, be it in regard to fat or to sugar intake, may have beneficial effects on the liver status in settings of NAFLD. Furthermore, in more recent years, the intake of pre- and probiotics, but also of specific micronutrients or secondary plant compounds, has also been considered a means in the prevention and therapy of this disease. Despite intense research efforts during the last decades, our understanding of the effects of nutritional intake on the development as well as on the prevention and cure of NAFLD is still limited. Providing a better understanding of the effects of diet and especially of specific macro- and micronutrients as well as pre- and probiotics and secondary plant compounds in the context of the development of NAFLD and its progression could lead to novel prevention and therapeutic strategies for this metabolic liver disease. This Special Issue will thus include original research and scientific perspectives on the relationship between NAFLD and dietary constituents that may 1) be involved in the development of the disease and 2) prevent its onset and progression. Mechanistic insights defining the contribution of certain nutritional factors (e.g., macronutrients like fat and sugar but also micronutrients and secondary plant compounds as well as pre- and probiotics) to the occurrence and management of NAFLD will improve our understanding of the disease and eventually lead to the development of universally accepted prevention and therapeutic strategies.

Nutrition --- Dietary pattern --- Sarkopenia --- Non-alcoholic fatty liver disease --- Diabetes and Insulin resistance