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While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.
polyphenols --- n/a --- red wine --- apigenin --- tyrosol --- neurotrophic effects --- neuronal differentiation --- Okinawa diet --- colorectal --- antioxidant capacity --- olive oil --- vine --- alcohol --- antioxidant --- electrochemical technology --- Mediterranean diet --- allergy --- cardiovascular protection --- N2a murine neuronal cells --- cancers --- dementia --- wine --- resveratrol derivatives --- RW --- substituents phenyl rings --- efficacy towards diseases --- grape pomace --- metabolic disease --- Alzheimer --- biological targets --- wine flavonoids --- metabolites characterization --- diet --- hydroxytyrosol --- hormesis --- resveratrol --- cardiovascular disease --- nrf2 --- health --- synthesis strategies --- EVOO --- cancer --- hypertension
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Nutritional deficiencies, and different nutritional and dietary lifestyles, whether poor or absent of essential nutrients, aside from excess intake, can lead to inflammatory complications and loss of function. Bioactive compounds are non-nutritional components derived from plants, foods, and beverages with a multitude of biological effects. The improvement of analytical techniques has allowed scientific community to state that the regular consumption of bioactive phytochemicals is related to the prevention of numerous pathologies, through mechanisms that involve oxidative stress reduction, gene expression modulation, and even enzymatic activation inhibition.
quercetin --- nervous system --- molecular signals --- pharmacological potential --- cognitive impairment. --- micronuclei --- radioprotectors --- radiation effects --- melanoma --- PNT2 --- B16F10 cells --- Ulmus parvifolia --- wound healing --- matrix metalloproteinase --- transforming growth factor --- skin rejuvenation --- kaempferol --- naringin --- orientin --- rutin --- vitexin --- chlorogenic acid --- citric acid --- malic acid --- quinic acid --- rosmarinic acid --- curcumin --- nanocurcumin --- neurological disorders --- nanocarriers --- liposomes --- cancer --- diet --- flavonoids --- food supplements --- hormesis --- phytoestrogens --- sulforaphane --- resveratrol --- cardiovascular disease --- nanomedicine --- liposome --- nanoformulation --- RNA-dependent RNA polymerase --- remdesivir --- chloroquine --- SARS-CoV-2 --- COVID-19 --- spike glycoproteins --- Acorus calamus --- ethnomedicinal --- phytochemistry --- toxicity --- pharmacological action --- clinical trial --- neuroprotective --- neurological --- metabolic application --- kurarinone --- coronavirus --- HCoV-OC43 --- autophagy --- infection --- MRC-5 cell --- LC3 --- p62/SQSTM1 protein --- n/a
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To celebrate its 10th anniversary, the prestigious journal Cells launched a series of Special Issues in 2021. The Special Issue entitled “10th Anniversary of Cells—Advances in Cell Cycle” was launched together with other sister Special Issues under the umbrella “10th Anniversary of Cells.” The cell cycle is a series of events that drives cells to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phases. Cell cycle progression is mediated by cyclin-dependent kinases (CDKs) and their regulatory cyclin subunits. CDKs, such as CDK4/6, CDK2, and CDK1 (also known as CDC2), are serine/threonine kinases with a wide variety of substrates. CDKs are activated mainly by binding to their cyclin partners, whose expressions rise and fall throughout the cell cycle to mediate the temporal activation of each CDKs. Various cell cycle checkpoints exist to ensure that critical processes are engaged prior to progression to the next phase. These cell cycle checkpoints are the G1 (restriction) checkpoint, the G2/M DNA damage checkpoint, and the spindle assembly checkpoint (SAC).This Special Issue attracted the attention of many scientists in the cell cycle field and consists of 10 high quality papers, including four research articles and six scientific reviews: a great success. The four research articles focus on various important topics of the cell cycle using a broad range of model organisms, including yeast, sea urchins, green algae, and human cancer cell lines.
Research & information: general --- Biology, life sciences --- microalgae --- Desmodesmus quadricauda --- cell cycle --- starch --- lipids --- polyphosphate --- guanine --- confocal Raman microscopy --- prenatal life --- perinatal life --- 5-bromo-2′-deoxyuridine --- cerebellar neuroepithelium --- external granular layer --- neurogenetic timetables --- neurogenetic gradients --- apoptosis --- M2 muscarinic receptor --- glioblastoma --- aberrant mitosis --- mitotic spindle --- Leishmania spp. --- leishmaniases --- telomeres --- telomerase --- growth factors --- receptor tyrosine kinases --- G1 phase --- S phase --- G2 phase --- M phase --- Ras/Erk --- PI3K/Akt --- vitelline layer --- fertilization --- sea urchin eggs --- plasticity --- Ca2+ signaling --- actin --- DTT --- TCEP --- BPA-C8-Cy3 --- electron microscopy --- Nud1 --- Cdc15 --- MEN --- mitotic exit --- Dbf2 --- Mob1 --- spindle position checkpoint --- HSF1 --- HSF2 --- cell cycle arrest --- APC/C complex --- CDK --- CTD phosphatase --- RNA polymerase II --- CTD code --- transcription --- LDIR --- hormesis --- cancer --- p21Waf1(CDKN1A) --- n/a --- 5-bromo-2'-deoxyuridine
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Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development. Complex chemical processes often involve coupling between dynamics at vastly different length and time scales, as well as coupling of different physical models. The multiscale and multiphysics nature of those problems calls for delicate modeling approaches. This book showcases recent contributions in this field, from the development of modeling methodology to its application in supporting the design, development, and optimization of engineering processes.
wood dust --- nasal epithelia --- VOCs --- M1dG --- reactive oxygen species (ROS) --- nucleotide excision repair (NER) --- base excision repair (BER) --- oxidative DNA damage --- DNA damage response and repair network --- immune response --- autoimmunity --- systemic lupus erythematosus --- systemic sclerosis --- rheumatoid arthritis --- oxidative stress --- abasic sites --- chromatin organization --- apoptosis --- DNA damage --- general anesthesia --- neuraxial anesthesia --- comet assay --- chronic myeloid leukemia --- genetic instability --- DNA double-strand breaks --- DNA damage response --- benzo[a]pyrene --- BPDE-DNA adduct --- silymarin --- detoxification --- Nrf2 --- PXR --- DNA repair --- base excision repair (BER)glycosylases --- colorectal cancer --- reactive oxygen species --- metabolic adaptation --- drug resistance --- cancer --- thyroid --- thyroid cancer --- volcano --- metals --- metallome --- carcinogens --- hormesis --- environment pollution --- metal biocontamination --- n/a --- Diamond-Blackfan anemia --- 8-oxoguanine --- inflammatory cytokines --- erythrocyte lifespan
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Today, herbicide-resistant weeds dominate research and development efforts in the discipline of weed science. The incidence, management challenges, and cost of multiple herbicide-resistant weed populations are continually increasing worldwide. Crop varieties with multiple herbicide-resistance traits are being rapidly adopted by growers and land managers to keep ahead of the weed resistance tsunami. This Special Issue of Plants comprises papers that describe the current status and future outlook of herbicide resistance research and development in weedy and domestic plants, with topics covering the full spectrum from resistance mechanisms to resistance management. The unifying framework for this Special issue is the challenge posed to all of the contributing authors: What are the (potential) implications for herbicide resistance management?
best management practices --- crop competition --- herbicide resistance --- integrated weed management --- precision weed management --- site-specific weed management --- Citrus latifolia --- hairy beggarticks --- junglerice --- tropical sprangletop --- corn --- herbicide resistance trait --- maize --- soybean --- amino acid biosynthesis --- lipid biosynthesis --- mechanism of action --- plastoquinone biosynthesis --- pyrimidine biosynthesis --- target site --- weeds --- genomics --- plant genome assembly --- non-target site resistance --- population genomics --- genome scans --- population genetics --- non-target metabolomics --- GC-MS --- priming --- hormesis --- D1 protein --- acetolactate synthase --- tubulin --- ACCase --- EPSPS --- phytoene desaturase --- PPO --- glutamine synthetase --- auxin --- Non-target-site resistance --- herbicide mode of action --- co-existence --- environmental conditions --- resistance mutation --- fitness benefit --- fitness cost --- resistance management --- weed genomics --- herbicide resistance database --- herbicide resistance diagnostics --- precision herbicide resistance management --- functional genomics --- weed biology --- weed evolution --- integrated pest management --- sensitivity line --- ryegrass --- herbicide dose --- dose-response --- non-target-site resistance
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Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.
Coreopsis lanceolata L. --- UV-Vis --- methanogenesis --- Lythraceae --- flavanone --- grape marc --- TDDFT --- Ephedra sinica --- macrocyclic oligomer --- triple-negative breast cancer --- antioxidant --- purple prairie clover --- chalcone --- neuraminidase --- fatty acid synthase --- (?)-epigallocatechin gallate --- epidermal growth factor --- NMR spectroscopy --- Aluminum ion --- Onagraceae --- Hydrangea macrophylla --- synthetic analogues --- blue color development --- amyloid-? peptide --- FTIR --- oseltamivir carboxylate --- quantitative NMR --- phloroglucinolysis --- thin layer chromatography --- European historic leathers --- FASN inhibition --- ECD --- colorimetric tests --- taxanes --- cynandione A --- conservation method --- 5-O-caffeoylquinic acid --- ellagitannin --- PC12 --- condensed tannin --- Trapa taiwanensis Nakai --- 1H-NMR --- Acacia --- (?)-epigallocatechin 3-gallate --- Geranium thunbergii --- condensed tannins --- immunomodulatory effect --- Acacia mearnsii bark --- Escherichia coli --- oligomer --- Horner–Wadsworth–Emmons reaction --- lung tumor --- Aspergillus fumigates --- in vitro batch fermentation --- metal complex --- Myrtaceae --- Cynanchum auriculatum --- molecular interactions --- phenolic glycoside --- bamboo leaf extract --- stability --- Microsporum canis --- Cynanchum wilfordii --- thiolysis --- anti-inflammation --- hydrolysable tannin --- geraniin --- NGF --- polyphenol --- revision --- ESI-mass --- bioactivity --- antifungal activities --- interferon-? --- antitumor effect --- tannin composition --- oenothein B --- zanamivir --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- anticancer activity --- proanthocyanidin --- vegetable tanning --- Dittrichia viscosa --- differentiation --- aurone --- antioxidants --- protein precipitation --- apoptosis --- polyphenolic FASN inhibitors --- forage legume --- biological activities --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- overlay method --- spectroscopy --- wattle tannin --- immune checkpoint --- hormesis --- 3-O-glucosyldelphinidin --- gallotannin --- proanthocyanidins --- fatty acids --- flavonol --- inhibition --- structure --- Candida spp. --- Malassezia spp. --- ORAC assay --- neuroprotection --- crystal structure --- tannins
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Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.
Vitamin D --- Multiple Sclerosis --- symptom --- neurodegeneration --- oxidative injury --- Parkinson’s disease --- terpenes, rotenone --- thymol --- Alzheimer’s disease --- Centella asiatica --- hippocampus --- protein poshophatase 2 --- glycogen synthase kinase 3 --- B-cell lymphoma 2 --- neuroprotection --- nutraceuticals --- bioavailability --- stress response --- neurodegenerative disease --- bioactive compound --- natural extract --- β-amyloid peptide --- tau protein --- clinical trial --- human studies --- animal studies --- in vitro studies --- curcumin --- free radicals --- heme oxygenase --- safety profile --- type 2 diabetes --- inflammation --- vascular damage --- learning --- memory --- natural compound --- oxidative stress --- cognitive dysfunction --- cell death --- synapse loss --- protein aggregation --- neuroinflammation --- algae --- seaweeds --- neurodegenerative diseases --- auraptene --- dopamine neuron --- antioxidant --- mitochondria --- Chionanthus retusus --- flavonoid --- flower --- HO-1 --- NO --- Lippia citriodora --- VEE --- Vs --- relaxation --- depression --- cyclic AMP --- calcium --- blood–brain barrier --- catechin --- cognition --- epigallocatechin gallate --- green tea --- microbiota --- 5-(3,5-dihydroxyphenyl)-γ-valerolactone --- ascaroside pheromone --- C. elegans --- dauer --- neuronal signaling --- sexual behavior --- survival signals --- proteostasis --- chaperones --- autophagy --- ubiquitin-proteasome --- unfolded protein response --- natural compounds --- natural products --- ethics --- patients’ autonomy --- beneficence --- nonmaleficence --- medical liability --- Parkinson’s disease (PD) --- mitochondrial dysfunction --- dynamics --- hormesis --- ubiquitin‒proteasome system (UPS) --- mitophagy --- n/a --- Parkinson's disease --- Alzheimer's disease --- blood-brain barrier --- patients' autonomy --- Parkinson's disease (PD)
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In recent years, heavy metals have been widely used in agricultural, chemical, domestic, and technological applications, causing environmental and soil contaminations. Heavy metals enter the plant system through soil or via the atmosphere, and can accumulate, affecting physiological processes, plant growth, yield, and human health if heavy metals are stored in edible tissues. Understanding the regulation mechanisms of plant heavy metals accumulation and partitioning is important to improve the safety of the food chain. In this Special Issue book, a total of 19 articles were included; four reviews covering phytoremediation, manganese phytotoxicity in plants, the effect of cadmium on plant development, the genetic characteristics of Cd accumulation, and the research status of genes and QTLs in rice, respectively, as well as fifteen original research articles, mainly regarding the impact of cadmium on plants. Cadmium was therefore the predominant topic of this Special Issue, increasing the attention of the research community on the negative impacts determined by cadmium or cadmium associated with other heavy metals. The articles have highlighted a great genetic variability, suggesting different possibilities for accumulation, translocation and the reduction or control of heavy metal toxicity in plants.
cotton (Gossypium hirsutum L.) --- transcriptome --- Cd stress --- GhHMAD5 --- overexpression --- VIGS (virus induced gene silence) --- cadmium --- glycinebetaine --- photosynthesis --- ultrastructure --- tobacco (Nicotiana tabacum L.) --- Cadmium --- hyperaccumulator --- Viola baoshanensis --- detoxification --- Cd --- PtoABCG36 --- tolerance --- poplar --- accumulation --- efflux --- phytoremediation --- heavy metals --- hyperaccumulation --- plant genotype improvement --- soil management --- cadmium accumulation --- absorption and transport --- QTL location --- mapping population --- rice (Oryza sativa L.) --- selenium --- cadmium stress --- auxin --- root architecture --- phosphate transporter --- Nicotiana tabacum --- oxidative stress --- cell cycle --- cell wall --- germination --- reproduction --- plant growth and development --- antioxidative system --- Brassicaceae family --- mitogen-activated protein kinases --- Ulva compressa --- antioxidant --- metal chelator --- in vivo chlorophyll a florescence --- physiology --- mitogen activated protein kinases --- metal accumulation --- DNA methylation --- ABCC transporters --- HMA2 --- wheat --- metal stress tolerance --- manganese toxicity --- Mn detoxification --- tolerance mechanism --- gene function --- subcellular compartment --- lead --- nicotianamine --- mugineic acid --- heavy metal --- toxic metal --- durum wheat --- Arabidopsis --- small heat shock protein --- OsMSR3 --- copper stress --- reactive oxygen species --- copper and zinc --- expression in bacteria --- metallothioneins --- marine alga --- Brassica campestris L. --- glutathione synthetase --- glutathione S-transferase --- alternative splicing --- Italian ryegrass root --- LmAUX1 --- hormesis --- growth --- chlorophyll a fluorescence --- n/a
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