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Periodical
Development of detection technologies for bacterial neurotoxins and their validation in food matrices ... annual report.
Authors: ---
ISSN: 23782374 Year: 2007 Publisher: [Washington, D.C.] : U.S. Dept. of Agriculture, Agricultural Research Service

Molecular neurosurgery with targeted toxins
Authors: ---
ISBN: 1280358157 9786610358151 159259896X 1588291995 1617374202 Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Abstract

The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.


Periodical
Neurotoxicity research.
Author:
ISSN: 14763524 10298428 Year: 1999 Publisher: [Amsterdam?] : Mountain House, TN : New York : Harwood Academic Publishers F.P. Graham Pub. Co. Springer

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Keywords

Neurotoxicology --- Toxicology --- Neurotoxic agents --- Nervous system --- Neurosciences --- Neurons --- Apoptosis --- Cytoprotection --- Nerve Degeneration --- Nerve Regeneration --- Neurotoxins --- Degeneration --- Regeneration --- drug effects --- Apoptosis. --- Cytoprotection. --- Nerve Degeneration. --- Nerve Regeneration. --- Neurotoxins. --- Neurosciences. --- Neurotoxic agents. --- Neurotoxicology. --- Toxicology. --- drug effects. --- Degeneration. --- Regeneration. --- Chemicals --- Neurotoxicity --- Neuropoisons --- Neurotoxicants --- Neural sciences --- Neurological sciences --- Neuroscience --- Nerve regeneration --- Neural regeneration --- Neuron regeneration --- Degeneration, Nerve --- Nerve degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Alpha-Neurotoxins --- Excitatory Neurotoxins --- Excitotoxin --- Excitotoxins --- Alpha Neurotoxins --- Neurotoxins, Excitatory --- Nerve Regenerations --- Regeneration, Nerve --- Regenerations, Nerve --- Neuron Degeneration --- Degeneration, Neuron --- Degenerations, Nerve --- Degenerations, Neuron --- Nerve Degenerations --- Neuron Degenerations --- Cell Protection --- Protection, Cell --- Apoptosis, Extrinsic Pathway --- Apoptosis, Intrinsic Pathway --- Programmed Cell Death, Type I --- Apoptoses, Extrinsic Pathway --- Apoptoses, Intrinsic Pathway --- Extrinsic Pathway Apoptoses --- Extrinsic Pathway Apoptosis --- Intrinsic Pathway Apoptoses --- Intrinsic Pathway Apoptosis --- Degeneration and regeneration --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Medical sciences --- Nerve grafting --- Regeneration (Biology) --- Degeneration (Pathology) --- Nerve Transfer --- Necrosis --- Cell Death --- Clonal Deletion --- Superantigens --- Caspases --- Caspase 1 --- In Situ Nick-End Labeling --- Cellular Apoptosis Susceptibility Protein --- Genes, Transgenic, Suicide --- Organs (Anatomy) --- Cell death --- Chemistry --- Health Sciences --- Life Sciences --- Clinical Medicine --- General and Others --- Nerve Tissue Regeneration --- Nervous Tissue Regeneration --- Neural Tissue Regeneration --- Nerve Tissue Regenerations --- Nervous Tissue Regenerations --- Neural Tissue Regenerations --- Regeneration, Nerve Tissue --- Regeneration, Nervous Tissue --- Regeneration, Neural Tissue --- Tissue Regeneration, Nerve --- Tissue Regeneration, Nervous --- Tissue Regeneration, Neural --- Caspase-Dependent Apoptosis --- Classic Apoptosis --- Classical Apoptosis --- Programmed Cell Death --- Apoptosis, Caspase-Dependent --- Apoptosis, Classic --- Apoptosis, Classical --- Caspase Dependent Apoptosis --- Cell Death, Programmed --- Classic Apoptoses --- Alpha-Neurotoxin --- Excitatory Neurotoxin --- Neurotoxin --- Alpha Neurotoxin --- Neurotoxin, Excitatory --- Neurotoxicologia --- Toxicologia --- Neurotoxines --- Regeneració del sistema nerviós

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