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Third generation EGFR inhibitors : overcoming EGFR resistance and toxicity problems
Authors: --- ---
ISBN: 9780081026625 0081026625 9780081026618 0081026617 Year: 2019 Publisher: Amsterdam, Netherlands : Elsevier,

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Abstract

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics.


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Novel sensitizing agents for therapeutic anti-EGFR antibodies
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ISBN: 9780128215852 9780128215845 0128215852 Year: 2023 Publisher: London, England : Academic Press,

The EGF receptor family : biologic mechanisms and role in cancer
Author:
ISBN: 1280968265 9786610968268 0080472583 0121602818 9780121602819 9780080472584 9781280968266 6610968268 Year: 2004 Publisher: Amsterdam ; London : Elsevier Academic Press,

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The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particular


Book
Overcoming resistance to EGFR inhibitors in EGFR mutant NSCLC
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ISBN: 9780128228340 0128228342 9780128228333 0128228334 Year: 2023 Publisher: London, England ; San Diego, California ; Cambridge, Massachusetts : Academic press,

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Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer.

Keywords

Antineoplastic Agents. --- Carcinoma, Non-Small-Cell Lung. --- Genes, erbB-1. --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Genes, erbB1 --- c-erbB-1 Proto-Oncogenes --- v-erbB Oncogenes --- EGFR Genes --- Epidermal Growth Factor Receptor Genes --- Genes, EGFR --- c-erbB-1 Genes --- erbB-1 Genes --- v-erbB Genes --- EGFR Gene --- Gene, erbB1 --- c erbB 1 Genes --- c erbB 1 Proto Oncogenes --- c-erbB-1 Gene --- c-erbB-1 Proto-Oncogene --- erbB 1 Genes --- erbB-1 Gene --- erbB1 Gene --- erbB1 Genes --- v erbB Genes --- v erbB Oncogenes --- v-erbB Gene --- v-erbB Oncogene --- Nonsmall Cell Lung Cancer --- Carcinoma, Non-Small Cell Lung --- Non-Small Cell Lung Cancer --- Non-Small Cell Lung Carcinoma --- Non-Small-Cell Lung Carcinoma --- Carcinoma, Non Small Cell Lung --- Carcinomas, Non-Small-Cell Lung --- Lung Carcinoma, Non-Small-Cell --- Lung Carcinomas, Non-Small-Cell --- Non Small Cell Lung Carcinoma --- Non-Small-Cell Lung Carcinomas --- Lung Neoplasms --- Carcinoma, Small Cell --- Drug resistance. --- Lungs --- Cancer --- Chemotherapy. --- Resistance to drugs --- Pharmacology --- ErbB Receptors --- Drug Resistance --- ErbB Receptors. --- Lung Neoplasms. --- Drug Resistance.

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