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IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a frequent cause of kidney failure. Better understanding of the pathogenesis of IgAN and the related genetic, immunological, and cellular susceptibility factors are needed to enable the development of effective disease-specific therapy. This book brings together international experts to provide clinical and experimental studies and reviews with an emphasis on early diagnosis, prognosis, disease pathogenesis, determination of disease activity, and new strategies for treatment for IgAN.

Medicine --- obesity --- mesangial matrix expansion --- body mass index --- IgA nephropathy --- IgA Vasculitis --- IgA Nephropathy --- adults --- children --- presentation --- physiopathology --- genetics --- prognosis --- treatment --- IgA --- clinical trials --- kidney mesangium --- mouse model --- aberrantly glycosylated IgA1 --- galactose-deficient IgA1 --- glycosylation of IgA1 --- biomarker --- complement C3 --- O-glycosylation --- IgA1 --- autoantibody --- immune complex --- complement --- kidney --- nephrology --- IgA vasculitis --- nephritis --- kidney biopsy --- plasma cells --- CD38 --- renal pathology --- urinary galactose-deficient IgA1 --- KM55 --- crescents --- proteinuria --- glomerular filtration rate --- Oxford score --- n/a

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The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.

Galactose. --- Yeast fungi --- Molecular genetics. --- Yeasts --- Fungi --- Basidiomycetes --- Blastomycetes --- Endomycetales --- Glycosides --- Monosaccharides --- Microbiology. --- Microbial genetics. --- Microbial genomics. --- Cytology. --- Biochemistry. --- Biotechnology. --- Microbial Genetics and Genomics. --- Cell Biology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Genomics --- Microbial genetics --- Microorganisms --- Genetics --- Microbiology --- Microbial biology --- Chemical engineering --- Genetic engineering --- Composition --- Cell biology.

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The progress in the area of nanotechnology has opened the door for the fabrication of soft, biological, and composite nanomaterials for targeted applications. Nanomaterials are known to enhance the properties and functionality of composite materials several fold. The properties for the desired applications can often be achieved by the addition of small amounts of nanomaterials into soft materials such as polymers, gels, and biomaterials. This book condenses investigations by scientific groups from highly diverse research fields, which will be beneficial for the wider scientific community.

Technology: general issues --- oxygen nanobubbles --- phospholipids --- polyethylene glycol --- ultrasound imaging --- electrospinning --- nanocomposites --- porous TiO2 nanofiber --- light harvesting --- additive --- dye-sensitized solar cells --- graphene oxide --- Sertoli cells --- Leydig cells --- apoptosis --- oxidative stress --- mitochondrial membrane potential --- DNA damage --- chitosan --- polycaprolactone --- shape memory --- stretchability --- polyurethane --- biocomposite --- methotrexate --- cubic phase --- magnetocubosomes --- monoolein --- liquid crystalline phase --- drug delivery system --- alternating magnetic field --- laser ablation --- nanofibers --- poly(ethylene oxide) (PEO) --- Au nanoparticles --- neutralization --- characterization of materials --- depth-sensing indentation --- adhesion --- the BG method --- non-destructive testing --- reagent-free colorimetric assay --- galactose determination --- nanoceria --- agarose gel --- galactosemia diagnosis --- nanodiamond --- composite --- 3D-printed scaffold --- n/a

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This book collects 17 original research papers and 9 reviews that are part of the Special Issue “Cellular Oxidative Stress”, published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.

Medicine --- neuroinflammation --- clinical --- palmitoylethanolamide --- luteolin --- co-ultramicronization --- CNS pathology --- adaptive immune response --- cell homeostasis --- legumes --- liver --- hepatic steatosis --- lipid dyshomeostasis --- ROS --- traumatic brain injury --- palmitoylethanolamide (PEA) --- therapeutic strategies --- oxidative stress. --- RNA-Seq --- RPE --- Retinitis pigmentosa --- A2E --- diabetes --- glucose exposure --- oxidative stress --- Band 3 protein --- erythrocytes --- SO42− --- 4-hydroxy-2-nonenal --- 3-glutathionyl-4-hydroxynonanal --- astrocytoma cells --- soy --- soybeans --- soy foods --- antioxidants --- reactive oxygen species --- cardiovascular diseases --- cancer --- paw edema --- cashew nuts --- antioxidant --- inflammation --- polyphenols --- analgesic --- d-Galactose --- glycation --- SO42− uptake --- anion exchange --- diseases --- immune system --- NF-κB --- cigarette smoke extract --- nasal fibroblasts --- tissue inhibitor of metalloproteinases --- matrix metalloproteinase --- steroids --- Plasmodium falciparum --- syk kinase inhibitors --- artemisinin derivatives --- hemichromes --- cellular redox state --- mitochondrial function --- cisplatin nephrotoxicity --- acute pancreatitis --- obesity --- nitrosative stress --- PGC-1α --- microparticles --- vesiculation --- band 3 --- tert-Bytyl hydroperoxide t-BOOH --- nitric oxide donor --- calcium ionophore A23187 --- age-related macular degeneration (AMD) --- diet --- Substance-P --- adipose-derived stem cells --- paracrine factors --- epilepsy --- status epilepticus --- Trolox --- HeLa --- prooxidant --- AVD --- apoptosis --- neurodegeneration --- ncRNA --- miRNA --- tRNA fragments --- lncRNA --- circRNA --- preeclampsia --- hemostasis --- platelets --- coagulation --- fish --- mucosal immunity --- nasal immunity --- peroxide --- vitamin C --- NAC --- immunosenescence --- T cells --- vaccination --- aging --- microvascular permeability --- bradykinin --- interleukin 1β --- NADPH oxidase --- simvastatin --- molecular hydrogen --- autophagy --- matrix metalloproteinases --- reactive oxygen species (ROS) --- phytochemicals --- dietary chemicals --- natural compounds --- programmed cell death --- anoikis --- ferroptosis --- pyroptosis --- n/a