Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest

Nucleic acids. --- Biomolecules. --- Biological molecules --- Molecules --- Molecular biology --- Polynucleotides --- Biomolecules

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nucleic acids --- Synthesis --- Nucleic Acids --- biosynthesis --- -Polynucleotides --- Biomolecules --- -Synthesis --- Nucleic acid synthesis --- Nucleic acids. --- Nucleic Acids - biosynthesis --- Nucleic acids - Synthesis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book presents a novel method of synthesizing sequence-specific DNA binding pyrrole–imidazole (Py–Im) polyamides and demonstrates polyamides targeting longer base pairs than those previously reported and their cellular application. It discusses the development of the facile synthetic method of tandem hairpin Py–Im polyamides and the method of visualizing telomeres under mild conditions without harsh denaturation, as well as research resulting in the synthesis not only of previously reported tandem dimer polyamides but also longer tandem trimer and tetramer polyamides. Using fluorescently labeled tandem hairpin Py–Im polyamides targeting a human telomere repetitive sequence, the author successfully stained telomeres in fixed cells without denaturation. These fluorescently labeled tandem tetramer polyamides are able to visualize human telomeres with lower background signals than previous polyamide probes, suggesting that they have higher specificity for telomeres. As such, this book provides insights into recent advance in Py–Im polyamides, particularly the extension of the target sites and improvement of the specificity, which can be applied to the study of pyrrole–imidazole polyamides with higher sequence specificity and the function of telomeres.

Bioorganic chemistry. --- Nucleic acids. --- Bioorganic Chemistry. --- Nucleic Acid Chemistry. --- Polynucleotides --- Biomolecules --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.

Bacteriology. --- Nucleic acids. --- Proteins . --- Medical microbiology. --- Nucleic Acid Chemistry. --- Receptors. --- Medical Microbiology. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Polynucleotides --- Microbiology --- Cyclic nucleotides. --- Nucleotides

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This unique book takes a radically fresh approach in providing general information on the chemistry and biological activity of nucleic acids. The book is easily understood by those with a basic scientific background, and includes historical perspectives, an outline of essential features of DNA and RNA structure, and information on the chemical synthesis of biologically important nucleosides, nucleotides, and oligonucleotides. Nucleotide biosynthesis is crisply presented, as is the basic molecular biology of DNA and RNA. Recent exciting developments in RNA auto-catalysis are also featured. The final chapter contrasts the in vivo rearrangements that DNA can undergo wit the in vitro techniques of manipulation of DNA sequences in cloning mutagensis. Written from a chemical, structural, and molecular standing, this volume fills a longstanding need for a basic text on the nucleic acids.

Acides nucléiques --- Nucleic acids --- Nucleïnezuren --- Polynucleotides --- Zuren [Nucleïne] --- Nucleic Acids. --- 547.963.32 --- #WSCH:LOSH --- Acids, Nucleic --- Nucleic acids. --- 547.963.32 Nucleic acids --- Acides nucléiques --- Nucleic Acids --- Biomolecules