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Book
Chemical Biology of Sterols, Triterpenoids and Other Natural Products : A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday
Authors: ---
ISBN: 303897417X 3038974161 9783038974178 Year: 2019 Publisher: Basel, Switzerland : MDPI,

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Abstract

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules' 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

high-fat high-carbohydrate diet --- toxicity --- oxysterol --- n/a --- squalene cyclase --- sterol content --- sterolomics --- Polystichum --- Smith-Lemli-Opitz syndrome --- antifungals --- alkaloid --- cycloartenol synthase --- degeneration --- phytosterol --- Rhizopus arrhizus --- fibroblasts --- pod-blast --- fern --- cholesterol --- cytotoxic activity --- N-methylpiperidine. reductive deamination --- genetic disease --- isoprenoid --- steroid --- atherosclerosis --- granatane --- antioxidant --- wound healing --- development --- enzyme-assisted derivatization --- maturity --- terpene --- keratinocytes --- C4-demethylation complex (C4DMC) --- ?-sitosterol --- mesocarp --- sterol biosynthesis --- mechanism-based inactivators --- Mucorales --- gas chromatography-mass spectrometry (GC-MS) --- Girard reagent --- ROS --- sterol pattern --- N-methylcadaverine --- ?-tocopherol --- electrospray ionization-mass spectrometry --- human African trypanosomiasis --- HUVECs --- lipidomics --- campesterol --- triterpene --- oxyphytosterol --- leishmania --- Chagas disease --- LOX-1 --- sterol C24-methyltransferase --- antifungal effectivity --- ergosterol biosynthesis --- hormone --- glucose homeostasis --- retina --- solanaceae --- cholestanoic acid --- algal sterols --- cell migration --- withanolides --- insulin resistance --- Zingiber officinale --- posaconazole --- synthesis --- pre-diabetes --- pharmacognosy --- sterol --- 4-methylsterol --- oleanolic acid --- antiparasitic drugs --- lupeol --- oilseed --- aurelianolides --- divalent metal co-factor ligation --- bile alcohol --- phytosterols --- azoles --- infectious disease --- gingerols --- UV-radiation --- oil bodies --- ZnO --- sterol 14?-demethylase --- stigmasterol


Book
Drug delivery technology development in Canada
Authors: ---
ISBN: 3039280058 303928004X Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

Keywords

encapsulation --- biodistribution --- pharmaceutics --- targeted therapies --- gambogic acid --- GE11 peptide --- formulation and dosage form development --- transient modulation --- ROESY NMR spectroscopy --- bioaccessibility --- polymeric micelle --- pharmacological Inhibitors of HIF-1 and STAT3 --- nanoparticles --- Vitamin D --- drug discovery --- EGFR-targeted therapy --- translational research --- clinical trials --- doxorubicin --- dissolution --- drug development --- permeation enhancers --- Canada --- plant --- primary central nervous system lymphomas --- photostabilizers --- head and neck squamous cell carcinoma --- mouse models --- drug delivery systems --- melphalan --- hypoxia-induced chemoresistance --- skin --- virus --- circadian clock --- child friendly formulation --- adenanthin --- co-delivery --- canola oil deodorizer distillate --- Metaplex --- innovation --- controlled drug delivery --- nifedipine --- radiolabeling --- amphotericin B --- biological barriers --- blood-brain barrier (BBB) --- biologicals --- lipid nanoparticles --- oral formulation --- phytosterols --- medical devices --- chronotherapy --- oral --- cationic gemini surfactant --- route of administration --- drug delivery --- intra-arterial chemotherapy --- developing world --- sustained delivery --- water miscible solvents --- combination therapy --- antibodies --- throughput --- magnetic fields --- liposomes --- medulloblastoma --- drug-resistant melanoma --- rosmarinic acid --- topical formulation --- TNO gastrointestinal model --- gastrointestinal simulator --- malignant gliomas --- transdermal drug delivery --- oral delivery --- precision medicine --- 3D spheroid --- flavonoids --- staurosporine --- DOX-Vit D --- loading gradients --- bacteriophage --- phospholipid complex --- triggered drug release --- HIF-1 --- phage display --- pharmacokinetics --- emulsion --- quercetin --- cisplatin --- parasitic infections --- remote loading --- HAV6 cadherin peptide --- blood-brain barrier --- inclusion complex --- tocopherols --- STAT3 --- ultrasound --- liposome --- fungal infections --- magnetic resonance imaging (MRI) --- MG63 --- model orange juice --- radiation --- cancer --- mefloquine --- small molecules --- Drug Delivery Systems --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Delivery systems

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