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Diabetic nephropathies. --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Kidneys --- Complications --- Diseases

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Although diabetic kidney disease is the most prevalent cause of end-stage renal disease and the disease most often leading to chronic renal replacement therapy and kidney transplantation, there has been, in recent years, a steady increase in basic and clinical knowledge of the problem. In The Diabetic Kidney, a stellar group of international researchers and clinicians joins forces to independently survey recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. Drawing on many years of experience, the authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Not always in total agreement, their views reflect the present state of knowledge and its uncertainties, and offer a composite of different authoritative views on the causes of diabetic kidney disease. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and comprehensive descriptions of the most up-to-date views on the diagnosis and treatment of the disease. State of the art and illuminating, The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Diabetic nephropathies. --- Diabetes. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Kidneys --- Diseases --- Complications --- Endocrinology. --- Internal medicine --- Hormones --- Endocrinology .

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This book presents the latest information on the clinical-pathological features of diabetic kidney disease. The data included is based on a cohort study of biopsy-proven diabetic nephropathy patients and nephrosclerosis patients, who were observed over a long term, and on the long-term registry for diabetic nephropathy (diabetic kidney disease) in Japan. It provides a clinical-pathological axis in clinical settings, including differential pathological/clinical diagnoses of CKD in diabetic patients (e.g. the presence of “classic” diabetic nephropathy and/or nephrosclerosis and/or other primary kidney diseases). The abundant biopsy specimens with long-term medical records provide a detailed pathological and clinical description. The book also includes urine-sample data for developing and validating possible candidates for novel biomarkers for diabetic kidney disease. Many countries, including Japan, have ageing populations, in which nephrosclerosis contributes to the progression of kidney lesions in patients with diabetic kidney disease. As such, a comparison of a diabetic nephropathy cohort with nephrosclerosis is indispensable to offer better treatments. This comprehensive and informative book is an indispensible reference resource for all physicians and researchers in the field of nephrology and diabetes. .

Nephrology. --- Diabetes. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Internal medicine --- Kidneys --- Diseases --- Diabetic nephropathies. --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Complications

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This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.

Ronyó --- Ressonància magnètica --- Àtoms --- Spin (Física nuclear) --- Ressonància magnètica nuclear --- Ressonància paramagnètica electrònica --- Relaxació magnètica --- Ronyons --- Abdomen --- Aparell urinari --- Diüresi --- Glàndules suprarenals --- Malalties del ronyó --- Nefrologia --- Analytical chemistry. --- Biology—Technique. --- Radiology. --- Physiology. --- Medicine—Research. --- Biology—Research. --- Analytical Chemistry. --- Biological Techniques. --- Biomedical Research. --- Radiological physics --- Physics --- Radiation --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Chemistry, Analytic --- Chemistry --- Animal physiology --- Animals --- Biology --- Anatomy --- Physiology --- Analytical Chemistry --- Biological Techniques --- Imaging / Radiology --- Biomedicine, general --- Biological Imaging --- Radiology --- Renal Physiology --- Preclinical Research --- renal pathophysiology --- diabetic nephropathy --- circadian rhythm --- Magnetic field strength --- Radio frequency coils --- NCMRA --- CEMRA --- Open Access --- Biology, life sciences --- Scientific equipment, experiments & techniques --- Medical imaging --- Life sciences: general issues --- Medical research --- Fisiologia humana --- Imatges per ressonància magnètica --- Diagnòstic per ressonància magnètica nuclear --- IRM --- MR Imaging --- MRI --- Tomografia per ressonància magnètica nuclear --- Diagnòstic per la imatge --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà

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Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function—in both the short- and long-term—is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.

inflammation --- chronic kidney disease --- anemia --- anemia of inflammation --- ESA hyporesponsiveness --- renal tubular epithelial cells --- macrophages --- lipocalin-2 --- iron --- cilastatin --- hypoxia inducible factor-1-α --- ischemia-reperfusion injury --- acute kidney injury --- cyclophilin A --- fibrosis --- renal fibrosis --- tubular necrosis --- preeclampsia --- podocytes --- VEGF --- FSGS --- proteinuria --- endocan --- ESM-1 --- renal replacement therapy --- kidney transplantation --- biomarker --- diabetic nephropathy --- focal segmental glomerulosclerosis --- innate immunity --- membranous nephropathy --- minimal change diseases --- TLR --- NOX1 --- ML171 --- reactive oxygen species --- ERK --- T cells --- glomerulonephritis --- chemokines --- renal disease --- DJ-1 --- ND-13 --- renal inflammation --- oxidative stress --- UUO --- autophagy --- apoptosis --- trehalose --- simvastatin --- endotoxin --- tubular apoptosis --- cytochrome C --- Bcl-XL --- survivin --- hypercholesterolemia --- xanthine oxidase --- NF-κB pathway --- tertiary lymphoid organs --- B cells --- BAFF --- kidney fibrosis --- myofibroblast activation --- extracellular matrix --- Hippo pathway --- verteporfin --- IgAN --- CKD --- progression --- ACEI --- corticosteroids --- costimulation --- coinhibition --- kidney transplant --- SPR --- protein binding affinity --- adaptive immunity --- epithelial-to-mesenchymal transition --- E. cava extracts --- dieckol --- spontaneously hypertensive rats --- angiotensin II --- n/a