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Pesticides --- Toxicology --- Congresses --- Toxicologie --- Congrès --- Mechanism of action --- Toxic Actions --- Specialty Uses of Chemicals --- Agrochemicals --- Chemical Actions and Uses --- Chemicals and Drugs --- Plant and Crop Sciences. Plant and Crop Protection --- Congresses. --- Chemical Control --- Chemical Control. --- Congrès

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Amino Acids. --- Peptides. --- 547.466 --- Polypeptides --- Acids, Amino --- Amino derivatives of carboxylic acids. Amino acids --- Amino acids. --- 547.466 Amino derivatives of carboxylic acids. Amino acids --- Amino acids --- Peptides --- Acides aminés --- Peptide --- Polypeptide --- Amino Acid --- Acid, Amino --- Amino Acids --- Molecular structure. --- Antibiotics --- Chemical actions --- Conformation --- Synthesis

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Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications.

Camptothecin --- Neoplasms --- Antineoplastic Agents, Phytogenic --- Camptothecin. --- Cancer --- therapeutic use. --- drug therapy. --- analogs & derivatives. --- pharmacology. --- Chemotherapy. --- Chimiothérapie --- Chemotherapy --- therapeutic use --- drug therapy --- analogs and derivatives --- pharmacology --- Cancer -- Chemotherapy. --- Alkaloids --- Diseases --- Therapeutics --- Antineoplastic Agents --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Heterocyclic Compounds --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Pharmacology --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Antiviral agents --- Treatment --- Oncology  . --- Cancer - Chemotherapy --- Camptothecin - therapeutic use --- Neoplasms - drug therapy --- Antineoplastic Agents, Phytogenic - therapeutic use --- Camptothecin - analogs and derivatives --- Camptothecin - pharmacology

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Single molecule tools have begun to revolutionize the molecular sciences, from biophysics to chemistry to cell biology. They hold the promise to be able to directly observe previously unseen molecular heterogeneities, quantitatively dissect complex reaction kinetics, ultimately miniaturize enzyme assays, image components of spatially distributed samples, probe the mechanical properties of single molecules in their native environment, and ""just look at the thing"" as anticipated by the visionary Richard Feynman already half a century ago. This volume captures a snapshot of this vibrant, rap

Molecular biology --- Enzymology. --- Ultrastructure (Biology) --- Methodology. --- Ultrastructure (Biology). --- Biosensors. --- Fluorescence spectroscopy. --- Fluorescent probes. --- Luminescence spectroscopy. --- Luminescent probes. --- Molecular biology -- Methodology. --- Fluorometry --- Laboratory Chemicals --- Spectrum Analysis --- Luminescent Measurements --- Chemistry Techniques, Analytical --- Specialty Uses of Chemicals --- Spectrometry, Fluorescence --- Molecular Probes --- Chemical Actions and Uses --- Investigative Techniques --- Photometry --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Biophysics --- Molecular biology. --- Genetics --- Biochemistry --- Optics and Photonics --- Diagnostic Imaging --- Chemistry --- Diagnostic Techniques and Procedures --- Physics --- Biological Science Disciplines --- Molecular Biology --- Microscopy --- Diagnosis --- Natural Science Disciplines --- Disciplines and Occupations --- Fine structure (Biology) --- Nanobiology --- Cells --- Microstructure --- Nanoscience --- Enzymes

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Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been

Anti-Bacterial agents -- Biosynthesis. --- Biological products -- Biosynthesis. --- Carbohydrates -- Biosynthesis. --- Peptide Biosynthesis --- Biological Products --- Anti-Bacterial Agents --- Polyketide Synthases --- Enzymes --- Carbohydrates --- Complex Mixtures --- Enzymes and Coenzymes --- Anti-Infective Agents --- Biochemical Processes --- Multienzyme Complexes --- Metabolism --- Chemicals and Drugs --- Carbon-Carbon Ligases --- Biochemical Phenomena --- Ligases --- Therapeutic Uses --- Metabolic Phenomena --- Chemical Processes --- Phenomena and Processes --- Chemical Phenomena --- Pharmacologic Actions --- Chemical Actions and Uses --- Biosynthesis. --- Peptides --- Polyketides --- Synthesis. --- Microbial biotechnology. --- Carbs (Carbohydrates) --- Peptide synthesis --- Acetogenins --- Biological synthesis --- Synthesis, Biological --- Microorganisms --- Biotechnology --- Biomolecules --- Organic compounds --- Glycomics --- Ketenes --- Polymers --- Biochemical engineering --- Biochemistry --- Synthetic biology --- Biochemical templates --- Industrial microbiology --- Biotechnological microorganisms --- Synthesis