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Stem Cell Therapy & Tissue Engineering for Cardiovascular Repair Dib, Taylor, Diethrich Stem Cell Therapy & Tissue Engineering for Cardiovascular Repair serves as an essential reference material covering these emerging technologies in cardiovascular research. Written by prominent world authorities presenting commissioned summaries, Stem Cell Therapy & Tissue Engineering for Cardiovascular Repair discusses the spectrum of stem cell and tissue engineering from basic research to clinical applications, offering a comprehensive, integrated reference. Key Features: Covers the fields of translational research and clinical applications including, - Pertinent information on cell isolation, expansion, and delivery, both in animals and humans - Overview of embryonic, bone marrow, and myoblast cell culturing and transplantation - Detailed explanations of the FDA regulatory pathways for cell production - Preclinical requirements for investigational new drug applications. - Regulatory requirements that can be applied to a variety of stem cell therapies Stem Cell Therapy & Tissue Engineering for Cardiovascular Repair is essential for all cardiovascular research scientists, clinical researchers, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of stem cell therapy and tissue engineering for cardiovascular repair. the Editors: Nabil Dib, M.D., M.Sc, F.A.C.C, Director of Interventional Cardiology Research, Arizona Heart Institute and Heart Hospital, Phoenix, Arizona Doris Taylor, Ph.D., Bakken Professor, Director, Center for Cardiovascular Repair, University of Minnesota, Minneapolis, Minnesota Edward B. Diethrich, M.D., Medical Director, Arizona Heart Institute and Heart Hospital, Phoenix, Arizona.
Heart --- Myoblast transfer therapy. --- Diseases --- Treatment. --- MTT (Myoblast transfer therapy) --- Myoblast transfer --- Myoblasts --- Cellular therapy --- Transplantation --- Biomedical engineering. --- Cardiology. --- Medicine. --- Biomedical Engineering and Bioengineering. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Internal medicine --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biomedicine, general. --- Health Workforce
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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
n/a --- biomaterial --- redifferentiation --- regenerative medicine --- skeletal muscle regeneration --- furcation defects --- Platelet-Rich Plasma (PRP) --- PRP --- fracture --- fibrin sealant --- periodontal surgery --- bone regeneration --- serum derived from plasma rich in growth factors (s-PRGF) --- cartilage repair --- myofibroblasts --- autologous platelet concentrates --- burns --- satellite cells --- articular cartilage --- stem cell niche --- wound healing --- quantification --- growth factors --- biologics --- platelet rich plasma --- meniscus --- adipose tissue --- Carprofen --- platelet-rich fibrin --- platelets --- hyperacute serum --- bone defects --- serum eye drops --- corneal epithelial defect --- fibrosis --- dog --- myoblasts --- differentiation --- chronic meniscal lesion --- horizontal meniscal tear --- PRGF --- collagen hydrogels --- periodontal defects --- bone grafting material --- composition --- cell therapy --- bone healing --- tissue healing --- trephination --- plasma rich plasma (PRP) --- bone repair --- plasma rich in growth factors --- knee arthrosis --- meniscus tear --- cornea regeneration --- wrist osteoarthritis --- periosteal sheet --- Platelet-Poor Plasma (PPP) --- platelet-rich plasma --- microfat --- bone grafting --- hyaluronic acid (NaHA) --- periodontal regeneration --- meniscus repair --- photobiomodulation therapy --- growth --- myogenesis --- blood derived products --- low-level laser therapy
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Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.
aging heart --- Bcl-2 family --- mitochondria --- programmed cell death --- fatty acid oxidation --- palmitate --- oleate --- m.3243A> --- G mutation --- MT-ATP6 --- m.8909T> --- C --- ATP synthase --- nephropathy --- oxidative phosphorylation --- mitochondrial disease --- cardiolipin --- Barth syndrome --- Sengers syndrome --- respiratory chain --- Dilated Cardiomyopathy with Ataxia --- cardiomyopathy --- mammalian complex I --- NADH dehydrogenase --- complex I assembly --- complex I structure --- complex I deficiency --- supernumerary subunits --- electron transport chain --- mitochondrial dysfunction --- Leigh syndrome --- mitochondrial diseases --- yeast --- Saccharomyces cerevisiae --- pet mutants --- pancreatic endocrine cells --- mathematical model --- cellular bioenergetics --- diabetes --- glucagon --- insulin --- exercise --- immune system --- metabolic disease --- COVID-19 --- mitochondrial dynamics --- viral infections --- MAVS --- RIG-I --- MDA5 --- innate immune response --- SARS CoV-2 --- RSV --- influenza --- respiratory supercomplexes --- ROS --- ATP synthase/hydrolase --- mitochondrial permeability transition pore --- cristae --- cellular signaling --- human disease --- mitochondrial dynamic --- cell signaling --- cancer --- respiratory complexes --- oxidative stress --- mitochondrial DNA --- MTCYB mutations --- cytochrome b --- complex III --- aging --- energy metabolism --- entorhinal cortex --- lipoxidation-derived damage --- neurodegeneration --- oxidative damage --- protein import --- respiratory complex assembly --- supercomplexes --- mitochondrial proteostasis --- heart failure --- bioenergetics --- assembly factor --- atypical myopathy --- high-resolution respirometry --- toxicity assays --- cell culture --- equine primary myoblasts --- fibroblasts --- frozen tissue --- leukocytes --- oxygen consumption --- platelets --- respirometry --- skeletal muscle --- n/a
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This Special Issue of Nutrients on "Nutraceutical, Nutrition Supplements, and Human Health" provides readers with contemporary knowledge on the role of functional foods, dietary supplements, and nutraceuticals in improving overall health and preventing chronic diseases. Various renowned international scientists, physicians, and other healthcare professionals have contributed to this compendium of excellent laboratory and clinical studies. The manuscripts provide evidence-based knowledge of nutritional compounds/functional food to improve many health conditions, including metabolic disorders, cardiovascular disease, muscle metabolism, obesity, neurological disorders, infectious diseases, aging, and cancer. All contributions were thoroughly peer-reviewed by a distinguished panel of scientists, and only highly ranked manuscripts were included to ensure the quality of contents. This book is an excellent resource for academic personnel and students in nutrition research, dietitians, physicians, and consumers.
Lactobacillus salivarius --- otitis --- probiotic --- bacteriocin --- prevention --- Morus nigra L. --- black mulberry --- nutraceutical --- pharmacological properties --- coenzyme Q10 (CoQ10) --- bioavailability --- intestinal absorption --- neuroprotection --- fenugreek --- protein hydrolysate --- antiproliferative --- apoptosis --- antioxidant --- Caco2 cells --- catechins --- green tea extract --- herbal dietary supplements --- hepatotoxicity --- microbiome --- Streptococcus agalactiae --- GBS --- pregnancy --- cachexia --- plum --- cancer --- muscle wasting --- myoblasts --- protein synthesis --- graviola --- weight loss --- obesity --- blood glucose --- food composition --- metabolic syndrome --- natural products --- Carica papaya --- Bifidobacterium breve M-16V --- infant health --- clinical efficacy --- probiotics --- gut microbiota --- Autism spectrum disorder --- dietary supplements --- pediatric --- physician communication --- frankincense --- Boswellia --- boswellic acid --- lupeolic acid --- AKBA --- cytokine --- breast cancer --- pentacyclic triterpenic acid --- triterpenoid --- chorioallantoic membrane assay --- Platycodon grandiflorus root --- BMI --- body fat mass --- abdominal fat area --- wild rice --- metabolomics --- atherosclerosis --- LDL-r-KO mice --- cytokines --- 16S rDNA --- plasma --- feces --- proteins --- carbohydrates --- functional food --- curcumin --- formulated curcumin --- pharmacokinetics --- aurora kinase A --- hepatocellular carcinoma --- Dietary Supplement Label Database --- food description --- food classification --- FoodEx2 --- quelites --- supplementation --- arsenic --- vitamin K --- diet supplement --- age-related diseases --- vitamin K-dependent proteins --- pathological calcification --- inflammation --- skeletal muscles --- Bifidobacterium breve B-3 --- muscle mass --- mitochondria --- n/a
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