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Book
Conquering RAS : from biology to cancer therapy
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ISBN: 9780128035412 0128035412 9780128035054 0128035056 Year: 2017 Publisher: Amsterdam, [Netherlands] : Academic Press,

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Ras family GTPases
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ISBN: 1280852097 9786610852093 1402047088 1402043287 Year: 2006 Publisher: Dordrecht ; [London] : Springer,

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Abstract

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.


Book
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Authors: --- ---
ISBN: 9789814585088 9814585076 9789814585071 9814585084 Year: 2015 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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Abstract

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Keywords

Engineering. --- Computational Intelligence. --- Computational Biology/Bioinformatics. --- Cancer Research. --- Biomedical Engineering. --- Health Informatics. --- Appl.Mathematics/Computational Methods of Engineering. --- Oncology. --- Medical records --- Bioinformatics. --- Engineering mathematics. --- Biomedical engineering. --- Ingénierie --- Cancérologie --- Dossiers médicaux --- Bio-informatique --- Mathématiques de l'ingénieur --- Génie biomédical --- Data processing. --- Informatique --- Medical records_xData processing. --- Engineering & Applied Sciences --- Computer Science --- Ras oncogenes. --- Lungs --- Cancer. --- Lung cancer --- Bio-informatics --- Biological informatics --- Ras genes --- Mathematical and Computational Engineering. --- Biology --- Information science --- Computational biology --- Systems biology --- Guanosine triphosphatase genes --- Oncogenes --- Data processing --- Biomedical Engineering and Bioengineering. --- Engineering --- Engineering analysis --- Mathematical analysis --- EHR systems --- EHR technology --- EHRs (Electronic health records) --- Electronic health records --- Electronic medical records --- EMR systems --- EMRs (Electronic medical records) --- Information storage and retrieval systems --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Medicine --- Tumors --- Construction --- Industrial arts --- Technology --- Mathematics --- Medical care --- Computational intelligence. --- Cancer research. --- Health informatics. --- Applied mathematics. --- Clinical informatics --- Health informatics --- Medical information science --- Cancer research --- Intelligence, Computational --- Artificial intelligence --- Soft computing

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